rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Glomerulonephritis D005921 35 associated lipids
Psoriasis D011565 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Astrocytoma D001254 15 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Translocation, Genetic D014178 20 associated lipids
Cardiomegaly D006332 31 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Liedtke CM et al. Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells. 2003 Am. J. Physiol., Cell Physiol. pmid:12388079
Tan M et al. Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. 2003 J. Biol. Chem. pmid:12431976
Saraiva L et al. Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. 2003 J Enzyme Inhib Med Chem pmid:15008511
Wang Q et al. Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. 2003 J. Biol. Chem. pmid:14527959
Maddox JF et al. Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. 2003 Chem. Res. Toxicol. pmid:12755590
Frank GD et al. Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. 2003 Mol. Cell. Biol. pmid:12588978
Clark AS et al. Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. 2003 Cancer Res. pmid:12591726
Minami T et al. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. 2003 J. Biol. Chem. pmid:12493764
Glaser S et al. Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12505882
Ham YM et al. The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. 2003 J. Biol. Chem. pmid:14514687
Takizawa T et al. Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. 2003 Int. Arch. Allergy Immunol. pmid:12771544
Nishizawa S et al. Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. 2003 Mar-Apr J. Vasc. Res. pmid:12808353
Kohro S et al. Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. 2004 Anesth. Analg. pmid:15502023
Bey EA et al. Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. 2004 J. Immunol. pmid:15494525
Tan M et al. Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15499041
Welters HJ et al. Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. 2004 J. Mol. Endocrinol. pmid:14766004
Deszo EL et al. IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. 2004 Cell. Signal. pmid:14636897
Ryazanova LV et al. Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. 2004 J. Biol. Chem. pmid:14594813
Durrant D et al. The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. 2004 Biochem. Biophys. Res. Commun. pmid:15358112
Lladó A et al. Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. 2004 Mol. Biol. Cell pmid:15342779