rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Glioma D005910 112 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Park EJ and Kwon TK Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. 2011 Exp. Mol. Med. pmid:21971413
Clements RT et al. Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. 2011 Circulation pmid:21911819
Sarkar N et al. Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. 2011 Biochim. Biophys. Acta pmid:21723915
Das J et al. Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. 2010 PLoS ONE pmid:20830294
Filone CM et al. Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. 2010 PLoS ONE pmid:21124804
Wang Y et al. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. 2010 Am. J. Physiol. Renal Physiol. pmid:20861079
Kim KM et al. Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. 2010 Toxicol. Appl. Pharmacol. pmid:20060010
Ohno I et al. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19762431
Bhatt KH et al. Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. 2010 Mol. Immunol. pmid:19931912
Rohilla A et al. Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts. 2010 Biomed. Pharmacother. pmid:19914792
Shen SM et al. Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. 2010 Carcinogenesis pmid:20015864
McEneaney V et al. Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. 2010 J. Steroid Biochem. Mol. Biol. pmid:19804826
Behl M et al. Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C. 2010 Neurotoxicology pmid:20488202
Hwang YP et al. 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. 2010 Toxicol. Lett. pmid:20599481
Lanaspa MA et al. The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. 2010 J. Biol. Chem. pmid:20639513
Maioli E and Valacchi G Rottlerin: bases for a possible usage in psoriasis. 2010 Curr. Drug Metab. pmid:20540694
Arisaka M et al. Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. 2010 FEBS Lett. pmid:20122929
Wallerstedt E et al. Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. 2010 Diabetologia pmid:20151299
Liu J et al. The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells. 2010 J Tissue Eng Regen Med pmid:20033927
Shumilina E et al. Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. 2010 Cell. Physiol. Biochem. pmid:21063107