| MeSH term | MeSH ID | Detail |
|---|---|---|
| Translocation, Genetic | D014178 | 20 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Chlamydia Infections | D002690 | 7 associated lipids |
| Hyperhomocysteinemia | D020138 | 6 associated lipids |
| MERRF Syndrome | D017243 | 1 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cross T et al. | PKC-delta is an apoptotic lamin kinase. | 2000 | Oncogene | pmid:10822384 |
| Kurosu T et al. | Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta. | 2007 | Oncogene | pmid:17130834 |
| Li Z et al. | Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. | 2012 | Oncol. Rep. | pmid:22427054 |
| Zhao Z et al. | Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. | 2017 | Oncotarget | pmid:27999199 |
| Wang L et al. | Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. | 2016 | Oncotarget | pmid:27626499 |
| Yin X et al. | Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. | 2016 | Oncotarget | pmid:27582552 |
| Zhu Y et al. | Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. | 2017 | Oncotarget | pmid:28423559 |
| Schug TT | Targeting transcription through inhibition of TBP. | 2011 Jan-Feb | Oncotarget | pmid:21378415 |
| Faria CC et al. | Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. | 2015 | Oncotarget | pmid:26061748 |
| Song P et al. | PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. | 2014 | Oxid Med Cell Longev | pmid:25371776 |
| Thrower EC et al. | Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. | 2009 | Pancreas | pmid:19752773 |
| Wung BS et al. | Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. | 2006 | Pharmacol. Res. | pmid:16243536 |
| Xu H et al. | Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. | 2015 | Pharmacology | pmid:26021525 |
| Misuth M et al. | Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. | 2017 | Photodiagnosis Photodyn Ther | pmid:28373118 |
| Chan TK et al. | Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. | 2013 | Phytomedicine | pmid:23632085 |
| Juneja M et al. | Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. | 2017 | PLoS Biol. | pmid:28570591 |
| Xie L et al. | Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. | 2016 | PLoS ONE | pmid:27442243 |
| Atef ME and Anand-Srivastava MB | Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. | 2016 | PLoS ONE | pmid:27379421 |
| Leppänen T et al. | Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. | 2013 | PLoS ONE | pmid:23326354 |
| Chen BR et al. | Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. | 2012 | PLoS ONE | pmid:23155470 |