rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Translocation, Genetic D014178 20 associated lipids
Hypertrophy D006984 16 associated lipids
Astrocytoma D001254 15 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Chlamydia Infections D002690 7 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
MERRF Syndrome D017243 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Lange Y et al. Effect of protein kinase C on endoplasmic reticulum cholesterol. 2002 Biochem. Biophys. Res. Commun. pmid:11779197
Pandey S et al. Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. 2016 Biochem. Biophys. Res. Commun. pmid:27498028
Liu JF et al. FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. 2002 Biochem. Biophys. Res. Commun. pmid:12054499
Rushworth SA et al. Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. 2006 Biochem. Biophys. Res. Commun. pmid:16460683
Durrant D et al. The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. 2004 Biochem. Biophys. Res. Commun. pmid:15358112
You HJ et al. A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. 2004 Biochem. Biophys. Res. Commun. pmid:15358156
Chintalgattu V and Katwa LC Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis. 2009 Biochem. Biophys. Res. Commun. pmid:19540196
Gschwendt M et al. Rottlerin, a novel protein kinase inhibitor. 1994 Biochem. Biophys. Res. Commun. pmid:8123051
Wert MM and Palfrey HC Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. 2000 Biochem. J. pmid:11062070
Davies SP et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. 2000 Biochem. J. pmid:10998351