rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Rhabdomyosarcoma D012208 7 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Translocation, Genetic D014178 20 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
MERRF Syndrome D017243 1 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Lei L et al. Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). 2012 PLoS ONE pmid:22970301
Ku CS et al. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. 2012 J. Nutr. Biochem. pmid:22209005
Tcatchoff L et al. Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. 2012 PLoS ONE pmid:22792315
Mooi LY et al. Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. 2012 Asian Pac. J. Cancer Prev. pmid:22799301
Xing AP et al. Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. 2012 J. Biomed. Biotechnol. pmid:22754279
Maioli E et al. Rottlerin and curcumin: a comparative analysis. 2012 Ann. N. Y. Acad. Sci. pmid:22758638
Narumi K et al. Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). 2012 Int J Pharm pmid:22426323
Li Z et al. Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. 2012 Oncol. Rep. pmid:22427054
Shin EJ et al. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. 2012 Behav. Brain Res. pmid:22512859
Latorre E et al. Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. 2012 Mol. Cancer pmid:22436134
Haines RJ et al. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. 2012 J. Biol. Chem. pmid:22696221
Huang CY et al. Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. 2012 Arthritis Rheum. pmid:22674286
Barrias ES et al. Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cell. 2012 Microbes Infect. pmid:23010292
Hsu JL et al. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. 2012 Biochem. Pharmacol. pmid:22490701
Schug TT Targeting transcription through inhibition of TBP. 2011 Jan-Feb Oncotarget pmid:21378415
Ko NY et al. Interleukin-32α production is regulated by MyD88-dependent and independent pathways in IL-1β-stimulated human alveolar epithelial cells. 2011 Jan-Feb Immunobiology pmid:20430472
Li S et al. Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes. 2011 Mol. Cell. Neurosci. pmid:21708260
Malla N et al. Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway. 2011 PLoS ONE pmid:21673806
Zhang D et al. Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. 2011 Toxicol. Appl. Pharmacol. pmid:21310168
Lim SC et al. Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. 2011 Carcinogenesis pmid:21362627