rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Chlamydia Infections D002690 7 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Body Weight D001835 333 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Astrocytoma D001254 15 associated lipids
Asthma D001249 52 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Chen BR et al. Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. 2012 PLoS ONE pmid:23155470
Barrias ES et al. Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cell. 2012 Microbes Infect. pmid:23010292
Song BW et al. Protein kinase C activation stimulates mesenchymal stem cell adhesion through activation of focal adhesion kinase. 2013 Cell Transplant pmid:23006313
Chang WT et al. Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells. 2012 Anticancer Res. pmid:22993309
Lei L et al. Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). 2012 PLoS ONE pmid:22970301
Singh BN et al. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. 2012 Biochem. Pharmacol. pmid:22902833
Chen RX et al. Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. 2012 Cell. Physiol. Biochem. pmid:22832358
Mooi LY et al. Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. 2012 Asian Pac. J. Cancer Prev. pmid:22799301
Tcatchoff L et al. Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. 2012 PLoS ONE pmid:22792315
Maioli E et al. Rottlerin and curcumin: a comparative analysis. 2012 Ann. N. Y. Acad. Sci. pmid:22758638