rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Parkinson Disease D010300 53 associated lipids
Glioblastoma D005909 27 associated lipids
Hypertrophy D006984 16 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Chlamydia Infections D002690 7 associated lipids
MERRF Syndrome D017243 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Authors Title Published Journal PubMed Link
Rao VU et al. PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:14975926
Kato K et al. Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19837952
De Witt BJ et al. Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11133494
Sud N et al. Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18192589
Liedtke CM et al. Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11943682
Woo CH et al. VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15489375
Brown JM et al. Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16040631
Wang Y et al. Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization. 2008 Am. J. Physiol. Renal Physiol. pmid:17670899
Zhao H et al. Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. 2002 Am. J. Physiol. Renal Physiol. pmid:11880333
Wang Y et al. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. 2010 Am. J. Physiol. Renal Physiol. pmid:20861079
Wang Y et al. Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors. 2007 Am. J. Physiol., Cell Physiol. pmid:17625040
Ramnath RD et al. Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. 2008 Am. J. Physiol., Cell Physiol. pmid:18160487
Kilpatrick LE et al. A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. 2002 Am. J. Physiol., Cell Physiol. pmid:12055072
Liedtke CM et al. Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells. 2003 Am. J. Physiol., Cell Physiol. pmid:12388079
Kilpatrick LE et al. Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. 2000 Am. J. Physiol., Cell Physiol. pmid:11078718
Mishra R et al. TGF-beta-regulated collagen type I accumulation: role of Src-based signals. 2007 Am. J. Physiol., Cell Physiol. pmid:17135298
Hassan HA et al. Regulation of anion exchanger Slc26a6 by protein kinase C. 2007 Am. J. Physiol., Cell Physiol. pmid:17151144
Zhang H and Forman HJ Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. 2008 Am. J. Respir. Cell Mol. Biol. pmid:18048804
Shukla A et al. Asbestos-induced apoptosis is protein kinase C delta-dependent. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12626342
Harrington EO et al. Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12707019