rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Parkinson Disease D010300 53 associated lipids
Glioblastoma D005909 27 associated lipids
Hypertrophy D006984 16 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Chlamydia Infections D002690 7 associated lipids
MERRF Syndrome D017243 1 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Naskar S et al. Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. 2014 PLoS ONE pmid:25116170
Juneja M et al. Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. 2017 PLoS Biol. pmid:28570591
Chan TK et al. Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. 2013 Phytomedicine pmid:23632085
Misuth M et al. Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. 2017 Photodiagnosis Photodyn Ther pmid:28373118
Xu H et al. Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. 2015 Pharmacology pmid:26021525
Wung BS et al. Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. 2006 Pharmacol. Res. pmid:16243536
Thrower EC et al. Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini. 2009 Pancreas pmid:19752773
Song P et al. PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. 2014 Oxid Med Cell Longev pmid:25371776
Zhu Y et al. Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. 2017 Oncotarget pmid:28423559
Schug TT Targeting transcription through inhibition of TBP. 2011 Jan-Feb Oncotarget pmid:21378415