rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Parkinson Disease D010300 53 associated lipids
Glioblastoma D005909 27 associated lipids
Hypertrophy D006984 16 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Chlamydia Infections D002690 7 associated lipids
MERRF Syndrome D017243 1 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Takahashi T and Shibuya M The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. 2001 Biochem. Biophys. Res. Commun. pmid:11162532
Grandvaux N et al. Oxidant-dependent phosphorylation of p40phox in B lymphocytes. 2001 Biochem. Biophys. Res. Commun. pmid:11573965
Wang Z et al. Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. 2018 Biochem. Biophys. Res. Commun. pmid:29203243
Pandey S et al. Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. 2016 Biochem. Biophys. Res. Commun. pmid:27498028
Leung CH et al. PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. 2001 Biochem. Biophys. Res. Commun. pmid:11444839
Dietrich C et al. Rottlerin induces a transformed phenotype in human keratinocytes. 2001 Biochem. Biophys. Res. Commun. pmid:11401499
Fang Q et al. PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. 2008 Biochem. Biophys. Res. Commun. pmid:18342628
Huwiler A et al. Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. 2003 Biochem. Biophys. Res. Commun. pmid:12732207
Rushworth SA et al. Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. 2006 Biochem. Biophys. Res. Commun. pmid:16460683
Chintalgattu V and Katwa LC Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis. 2009 Biochem. Biophys. Res. Commun. pmid:19540196