| MeSH term | MeSH ID | Detail |
|---|---|---|
| MERRF Syndrome | D017243 | 1 associated lipids |
| Hyperhomocysteinemia | D020138 | 6 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Chlamydia Infections | D002690 | 7 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Translocation, Genetic | D014178 | 20 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kitazawa M et al. | Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. | 2003 | Neuroscience | pmid:12831855 |
| Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | 2003 | J. Biol. Chem. | pmid:12832423 |
| Shukla A et al. | Asbestos-induced apoptosis is protein kinase C delta-dependent. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12626342 |
| Gore-Hyer E et al. | Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. | 2003 | Arthritis Rheum. | pmid:12632435 |
| Susarla BT and Robinson MB | Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. | 2003 | J. Neurochem. | pmid:12859677 |
| Erclik MS and Mitchell J | The role of protein kinase C-delta in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11832354 |
| Zhao H et al. | Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:11880333 |
| Anantharam V et al. | Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. | 2002 | J. Neurosci. | pmid:11880503 |
| Sumitomo M et al. | Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. | 2002 | J. Clin. Invest. | pmid:11901191 |
| Todt JC et al. | Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. | 2002 | J. Biol. Chem. | pmid:12114511 |
| Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
| Blass M et al. | Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. | 2002 | Mol. Cell. Biol. | pmid:11739733 |
| Han JM et al. | Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. | 2002 | J. Biol. Chem. | pmid:11744693 |
| Kucich U et al. | Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:11804868 |
| Li B et al. | Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. | 2002 | J. Biol. Chem. | pmid:11796722 |
| Basu A et al. | Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. | 2002 | Exp. Cell Res. | pmid:12169276 |
| Cruciani V and Mikalsen SO | Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12127264 |
| Budnik LT and Mukhopadhyay AK | Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. | 2002 | Biol. Reprod. | pmid:12193405 |
| Wadsworth SJ and Goldfine H | Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome. | 2002 | Infect. Immun. | pmid:12117979 |
| Hendey B et al. | Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells. | 2002 | J. Leukoc. Biol. | pmid:11994512 |
| Fryer RM et al. | PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. | 2002 | Basic Res. Cardiol. | pmid:11998977 |
| Ghelli A et al. | Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | 2002 | Biochem. J. | pmid:12014986 |
| Liedtke CM et al. | Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11943682 |
| Kudo M et al. | Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12063302 |
| Lee YJ et al. | Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest. | 2002 | Cell Growth Differ. | pmid:12065247 |
| Bull ND and Barnett NL | Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ. | 2002 | J. Neurochem. | pmid:12065656 |
| Liu JF et al. | FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054499 |
| Kilpatrick LE et al. | A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:12055072 |
| Cipriani B et al. | Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens. | 2002 | J. Immunol. | pmid:12421956 |
| Kayali AG et al. | Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. | 2002 | Endocrinology | pmid:12239100 |
| Saito S et al. | Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. | 2002 | J. Biol. Chem. | pmid:12226102 |
| Niwa K et al. | Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells. | 2002 | Free Radic. Res. | pmid:12592666 |
| Bureik M et al. | Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors. | 2002 | Endocr. Res. | pmid:12530636 |
| Johnson CL et al. | Regulation of p53 stabilization by DNA damage and protein kinase C. | 2002 | Mol. Cancer Ther. | pmid:12492119 |
| Pickett CA et al. | Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. | 2002 | Mol. Endocrinol. | pmid:12456804 |
| Hai CM et al. | Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. | 2002 | Exp. Cell Res. | pmid:12372340 |
| Basu A and Miura A | Differential regulation of extrinsic and intrinsic cell death pathways by protein kinase C. | 2002 | Int. J. Mol. Med. | pmid:12373288 |
| Lesage GD et al. | Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. | 2002 | Hepatology | pmid:12198656 |
| Fryer RM et al. | Essential activation of PKC-delta in opioid-initiated cardioprotection. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179083 |
| De Witt BJ et al. | Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133494 |
| Takahashi T and Shibuya M | The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162532 |
| Shanmugam M et al. | A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. | 2001 | Cancer Lett. | pmid:11595128 |
| Wang GY et al. | Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11602672 |
| Vancurova I et al. | NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha. | 2001 | J. Biol. Chem. | pmid:11274209 |
| Solomou EE et al. | Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. | 2001 | J. Immunol. | pmid:11313407 |
| Morino K et al. | Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta. | 2001 | Endocrinology | pmid:11356718 |
| Braiman L et al. | Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle. | 2001 | Mol. Endocrinol. | pmid:11266508 |
| Leung CH et al. | PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11444839 |
| Dietrich C et al. | Rottlerin induces a transformed phenotype in human keratinocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401499 |
| Noya F et al. | p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7. | 2001 | J. Virol. | pmid:11390614 |