rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
MERRF Syndrome D017243 1 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Chlamydia Infections D002690 7 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Astrocytoma D001254 15 associated lipids
Hypertrophy D006984 16 associated lipids
Translocation, Genetic D014178 20 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Contreras X et al. IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. 2004 Microbes Infect. pmid:15488737
Kohro S et al. Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. 2004 Anesth. Analg. pmid:15502023
Schreckenberg R et al. Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. 2004 Cardiovasc. Res. pmid:15276481
Chintalgattu V and Katwa LC Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. 2004 J. Pharmacol. Exp. Ther. pmid:15240825
Li C et al. Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15217780
Nabha SM et al. Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. 2005 Oncogene pmid:15735693
Nitti M et al. Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. 2005 Free Radic. Biol. Med. pmid:15749380
Lewis AE et al. Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. 2005 Cell. Signal. pmid:15494216
Zhang J et al. PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. 2005 J. Cell. Biochem. pmid:16114000
Brown JM et al. Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. 2005 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16040631