rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
MERRF Syndrome D017243 1 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Chlamydia Infections D002690 7 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Astrocytoma D001254 15 associated lipids
Hypertrophy D006984 16 associated lipids
Translocation, Genetic D014178 20 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Lee SE et al. Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells. 2011 Toxicol. Lett. pmid:21238556
Yang QE et al. Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. 2011 Biol. Reprod. pmid:21191110
Sarkar N et al. Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. 2011 Biochim. Biophys. Acta pmid:21723915
Shirasugi I et al. Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. 2010 Biosci. Biotechnol. Biochem. pmid:21071833
Das J et al. Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. 2010 PLoS ONE pmid:20830294
Filone CM et al. Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. 2010 PLoS ONE pmid:21124804
Wang Y et al. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. 2010 Am. J. Physiol. Renal Physiol. pmid:20861079
Tang CH et al. The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. 2010 Arthritis Rheum. pmid:20862675
Jiang W et al. [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells]. 2010 Hua Xi Kou Qiang Yi Xue Za Zhi pmid:21179694
Ohno I et al. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19762431
McEneaney V et al. Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. 2010 J. Steroid Biochem. Mol. Biol. pmid:19804826
Behl M et al. Lead-induced accumulation of beta-amyloid in the choroid plexus: role of low density lipoprotein receptor protein-1 and protein kinase C. 2010 Neurotoxicology pmid:20488202
Hwang YP et al. 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. 2010 Toxicol. Lett. pmid:20599481
Lanaspa MA et al. The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. 2010 J. Biol. Chem. pmid:20639513
Maioli E and Valacchi G Rottlerin: bases for a possible usage in psoriasis. 2010 Curr. Drug Metab. pmid:20540694
Arisaka M et al. Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. 2010 FEBS Lett. pmid:20122929
Wallerstedt E et al. Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. 2010 Diabetologia pmid:20151299
Liu J et al. The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells. 2010 J Tissue Eng Regen Med pmid:20033927
Shumilina E et al. Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. 2010 Cell. Physiol. Biochem. pmid:21063107
Lee HG and Yang JH PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner. 2010 Chemosphere pmid:20846705