rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Chlamydia Infections D002690 7 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystic Fibrosis D003550 65 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Rohilla A et al. Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts. 2010 Biomed. Pharmacother. pmid:19914792
Itoh T et al. Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. 2008 Bioorg. Med. Chem. pmid:18328716
Shirasugi I et al. Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. 2010 Biosci. Biotechnol. Biochem. pmid:21071833
Pula G et al. PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. 2006 Blood pmid:16940418
Yamaguchi R et al. Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. 2016 Blood Cells Mol. Dis. pmid:26852662
Ni H et al. Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. 2003 Br. J. Haematol. pmid:12786795
Cho JY et al. Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. 2003 Br. J. Pharmacol. pmid:12970105
Jäntti MH et al. OX1 orexin/hypocretin receptor activation of phospholipase D. 2012 Br. J. Pharmacol. pmid:21718304
Obreja O et al. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. 2005 Brain pmid:15817518
Miller RL et al. Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. 2007 Brain Res. pmid:17662968
Lishmanov YB et al. Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. 2016 Bull. Exp. Biol. Med. pmid:27496038
Sun S et al. Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. 2017 Cancer Biomark pmid:29036789
Kishida O et al. Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. 2005 Cancer Chemother. Pharmacol. pmid:15723263
Yamaguchi K et al. Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. 2005 Cancer Chemother. Pharmacol. pmid:16012865
Shanmugam M et al. A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. 2001 Cancer Lett. pmid:11595128
Daveri E et al. Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. 2016 Cancer Lett. pmid:27343979
Oh JI et al. Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. 2005 Cancer Lett. pmid:16297709
Zhu M et al. Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. 2006 Cancer Lett. pmid:16455194
Kumar D et al. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. 2014 Cancer Lett. pmid:24125861
Huang M et al. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. 2014 Cancer Lett. pmid:25050737