rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
MERRF Syndrome D017243 1 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Translocation, Genetic D014178 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Psoriasis D011565 47 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Basu A et al. Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway. 2002 Exp. Cell Res. pmid:12169276
Hai CM et al. Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells. 2002 Exp. Cell Res. pmid:12372340
Gao FH et al. Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. 2009 Exp. Cell Res. pmid:19747914
Matsuoka H et al. Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways. 2009 Exp. Cell Res. pmid:19393235
Wang P et al. Relaxin Inhibits Cardiac Fibrosis in Diabetic Rats: Roles of Protein Kinase Cδ. 2018 Exp. Clin. Endocrinol. Diabetes pmid:28895644
Valacchi G et al. Rottlerin: a multifaced regulator of keratinocyte cell cycle. 2009 Exp. Dermatol. pmid:19492998
Dreixler JC et al. Protein kinase C subtypes and retinal ischemic preconditioning. 2008 Exp. Eye Res. pmid:18722601
Kawabata H et al. A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. 2015 Exp. Hematol. pmid:25633564
Byun HS et al. Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. 2008 Exp. Mol. Med. pmid:18446057
Park EJ and Kwon TK Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. 2011 Exp. Mol. Med. pmid:21971413