| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rottlerin?
Related references are published most in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Appl. Environ. Microbiol. (1)
- Others (10)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liedtke CM et al. | Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells. | 2003 | Am. J. Physiol., Cell Physiol. | pmid:12388079 |
| Tan M et al. | Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. | 2003 | J. Biol. Chem. | pmid:12431976 |
| Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | 2003 | J. Biol. Chem. | pmid:12832423 |
| Shukla A et al. | Asbestos-induced apoptosis is protein kinase C delta-dependent. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12626342 |
| Gore-Hyer E et al. | Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. | 2003 | Arthritis Rheum. | pmid:12632435 |
| Saraiva L et al. | Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta. | 2003 | J Enzyme Inhib Med Chem | pmid:15008511 |
| Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
| Wang Q et al. | Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. | 2003 | J. Biol. Chem. | pmid:14527959 |
| Wrede CE et al. | Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). | 2003 | J. Mol. Endocrinol. | pmid:12790799 |
| Deb DK et al. | Activation of protein kinase C delta by IFN-gamma. | 2003 | J. Immunol. | pmid:12817007 |
| Yamanaka K et al. | Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818569 |
| Kitamura K et al. | The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression. | 2003 | Genes Cells | pmid:12653960 |
| Cho JY et al. | Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. | 2003 | Br. J. Pharmacol. | pmid:12970105 |
| Tillman DM et al. | Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. | 2003 | Cancer Res. | pmid:12941843 |
| Trushin SA et al. | Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. | 2003 | Mol. Cell. Biol. | pmid:12972622 |
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| McCracken MA et al. | Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. | 2003 | Mol. Cancer Ther. | pmid:12657722 |
| Blanquet PR et al. | A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus. | 2003 | Neuroscience | pmid:12699783 |
| Harrington EO et al. | Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12707019 |
| Wang L et al. | Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. | 2003 | Biochem. J. | pmid:12720544 |
| Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
| Hock MB and Brown MA | Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. | 2003 | J. Biol. Chem. | pmid:12738787 |
| Maddox JF et al. | Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. | 2003 | Chem. Res. Toxicol. | pmid:12755590 |
| Frank GD et al. | Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. | 2003 | Mol. Cell. Biol. | pmid:12588978 |
| Clark AS et al. | Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. | 2003 | Cancer Res. | pmid:12591726 |
| Minami T et al. | Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. | 2003 | J. Biol. Chem. | pmid:12493764 |
| Susarla BT and Robinson MB | Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. | 2003 | J. Neurochem. | pmid:12859677 |
| Glaser S et al. | Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12505882 |
| Ham YM et al. | The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. | 2003 | J. Biol. Chem. | pmid:14514687 |
| Domenicotti C et al. | A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. | 2003 | Biochem. Pharmacol. | pmid:14555230 |
| Takizawa T et al. | Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. | 2003 | Int. Arch. Allergy Immunol. | pmid:12771544 |
| Nishizawa S et al. | Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. | 2003 Mar-Apr | J. Vasc. Res. | pmid:12808353 |
| Frank DE and Carter WG | Laminin 5 deposition regulates keratinocyte polarization and persistent migration. | 2004 | J. Cell. Sci. | pmid:14996912 |
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| Cummings R et al. | Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. | 2004 | J. Biol. Chem. | pmid:15280372 |
| Anantharam V et al. | Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15681813 |
| Deszo EL et al. | IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. | 2004 | Cell. Signal. | pmid:14636897 |
| Ryazanova LV et al. | Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. | 2004 | J. Biol. Chem. | pmid:14594813 |
| Durrant D et al. | The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358112 |
| You HJ et al. | A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358156 |
| Deutsch E et al. | Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. | 2004 | J. Virol. | pmid:15331751 |
| Wheaton K and Riabowol K | Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. | 2004 | Mol. Cell. Biol. | pmid:15282327 |
| Schreckenberg R et al. | Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. | 2004 | Cardiovasc. Res. | pmid:15276481 |
| Chintalgattu V and Katwa LC | Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15240825 |
| Li C et al. | Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15217780 |
| Shin SY et al. | Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. | 2004 | J. Mol. Biol. | pmid:15223313 |
| Mimura Y et al. | Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. | 2004 | J. Invest. Dermatol. | pmid:15175028 |
| Woo CH et al. | Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. | 2004 | J. Immunol. | pmid:15557194 |
| Kang HS et al. | Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. | 2004 | Mol. Cells | pmid:15232218 |
| Cho CH et al. | Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:14704231 |