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EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. |
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Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. |
2011 |
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2011 |
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Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. |
2011 |
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2011 |
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Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. |
2011 |
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Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. |
2011 |
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Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. |
2011 |
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2011 Jan-Feb |
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Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. |
2012 |
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2012 |
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2012 |
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2012 |
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Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells. |
2012 |
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Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). |
2012 |
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Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. |
2012 |
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Rottlerin and curcumin: a comparative analysis. |
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Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). |
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2012 |
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2012 |
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Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. |
2012 |
Mol. Cancer |
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Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. |
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Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. |
2012 |
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uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. |
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Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism. |
2012 |
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Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. |
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Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. |
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Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase. |
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The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. |
2012 |
PLoS ONE |
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Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. |
2012 |
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2012 Sep-Oct |
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Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. |
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Neuroscience |
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PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. |
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Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. |
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PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. |
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Phytomedicine |
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PLoS ONE |
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Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. |
2013 |
PLoS ONE |
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PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. |
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Activation of protein kinase C delta reduces hepatocellular damage in ischemic preconditioned rat liver. |
2013 |
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Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. |
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Mol. Cancer |
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Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing. |
2013 Jan-Mar |
J Immunotoxicol |
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PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. |
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PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. |
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Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. |
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Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. |
2014 |
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Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. |
2014 |
Cell Death Dis |
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PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. |
2014 |
Oxid Med Cell Longev |
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PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. |
2014 |
PLoS ONE |
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Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. |
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PLoS ONE |
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Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. |
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Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. |
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Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression. |
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A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. |
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Development |
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Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis. |
2014 |
PLoS ONE |
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Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. |
2014 |
Cancer Lett. |
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Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells. |
2014 |
Mol Med Rep |
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Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. |
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Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. |
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J. Org. Chem. |
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Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. |
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Pharmacology |
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Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. |
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Mol Med Rep |
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Activation of PKC-δ in HTLV-1-infected T cells. |
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Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. |
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Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. |
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Enzyme Microb. Technol. |
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Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. |
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Clin. Exp. Pharmacol. Physiol. |
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Cancer Therapy with Phytochemicals: Present and Future Perspectives. |
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Biomed. Environ. Sci. |
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Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. |
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Oncotarget |
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In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. |
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Inflammation |
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