Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Springael C et al. | Rottlerin inhibits human T cell responses. | 2007 | Biochem. Pharmacol. | pmid:17141738 |
Singh BN et al. | Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. | 2012 | Biochem. Pharmacol. | pmid:22902833 |
Thabard W et al. | Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. | 2001 | Biochem. J. | pmid:11485567 |
Bain J et al. | The selectivity of protein kinase inhibitors: a further update. | 2007 | Biochem. J. | pmid:17850214 |
Ghelli A et al. | Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | 2002 | Biochem. J. | pmid:12014986 |
Wang L et al. | Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. | 2003 | Biochem. J. | pmid:12720544 |
Fan CY et al. | PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. | 2005 | Biochem. J. | pmid:15913451 |
Wert MM and Palfrey HC | Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. | 2000 | Biochem. J. | pmid:11062070 |
Davies SP et al. | Specificity and mechanism of action of some commonly used protein kinase inhibitors. | 2000 | Biochem. J. | pmid:10998351 |
Takahashi T and Shibuya M | The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162532 |
Grandvaux N et al. | Oxidant-dependent phosphorylation of p40phox in B lymphocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573965 |
Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
Wang Z et al. | Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29203243 |
Pandey S et al. | Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27498028 |
Leung CH et al. | PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11444839 |
Dietrich C et al. | Rottlerin induces a transformed phenotype in human keratinocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401499 |
Fang Q et al. | PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18342628 |
Liu JF et al. | FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054499 |
Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
Rushworth SA et al. | Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16460683 |
Durrant D et al. | The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358112 |
You HJ et al. | A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358156 |
Kim DC et al. | Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16182255 |
Kojima K et al. | Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18789895 |
Cristóvão AC et al. | PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23827392 |
Chintalgattu V and Katwa LC | Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19540196 |
Gschwendt M et al. | Rottlerin, a novel protein kinase inhibitor. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8123051 |
Shin EJ et al. | Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. | 2012 | Behav. Brain Res. | pmid:22512859 |
Fryer RM et al. | PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. | 2002 | Basic Res. Cardiol. | pmid:11998977 |
Xu SZ | Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17927688 |
Song KS et al. | Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. | 2008 | Autophagy | pmid:18424913 |
Ozpolat B et al. | PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. | 2007 Sep-Oct | Autophagy | pmid:17507797 |
Suguro T et al. | Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. | 2006 | Atherosclerosis | pmid:16157345 |
Zhu S et al. | PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24289563 |
Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
Gore-Hyer E et al. | Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. | 2003 | Arthritis Rheum. | pmid:12632435 |
Tang CH et al. | The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. | 2010 | Arthritis Rheum. | pmid:20862675 |
Huang CY et al. | Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. | 2012 | Arthritis Rheum. | pmid:22674286 |
Pakozdi A et al. | Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16872482 |
Collins NT et al. | Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16269664 |
Tan M et al. | Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15499041 |
Park YS et al. | Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17363696 |
Shin EJ et al. | Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. | 2016 | Arch. Toxicol. | pmid:25895139 |
Miskolci V et al. | Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. | 2003 | Arch. Biochem. Biophys. | pmid:12921778 |
Shivshankar P et al. | Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells. | 2008 | Appl. Environ. Microbiol. | pmid:18083882 |
Hsu PC et al. | Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. | 2006 | Apoptosis | pmid:16520895 |
Longpre JM and Loo G | Protection of human colon epithelial cells against deoxycholate by rottlerin. | 2008 | Apoptosis | pmid:18661240 |
Lim JH et al. | Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells. | 2008 | Apoptosis | pmid:18807195 |
Ashour AA et al. | Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. | 2014 | Apoptosis | pmid:24193916 |
Abdelnabi R et al. | Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. | 2017 | Antiviral Res. | pmid:28039020 |