rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
MERRF Syndrome D017243 1 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Translocation, Genetic D014178 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Psoriasis D011565 47 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia D007938 74 associated lipids
Kidney Diseases D007674 29 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Löber K et al. STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816. 2008 J. Cell. Biochem. pmid:17615556
Wang Y et al. Differential effects of dialysis and ultrafiltrate from individuals with CKD, with or without diabetes, on platelet phosphatidylserine externalization. 2008 Am. J. Physiol. Renal Physiol. pmid:17670899
Shivshankar P et al. Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells. 2008 Appl. Environ. Microbiol. pmid:18083882
Marengo B et al. Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. 2008 Free Radic. Biol. Med. pmid:17991446
Zhang H and Forman HJ Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. 2008 Am. J. Respir. Cell Mol. Biol. pmid:18048804
Basu A et al. Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. 2008 Cancer Res. pmid:18413747
Schonhoff CM et al. Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. 2008 Hepatology pmid:18273864
Hsu HY et al. Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. 2008 J. Cell. Physiol. pmid:18357586
Feng BY et al. Small-molecule aggregates inhibit amyloid polymerization. 2008 Nat. Chem. Biol. pmid:18223646
Lee MC et al. Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages. 2008 J. Leukoc. Biol. pmid:18511573
Ross R et al. Hypothalamic protein kinase C regulates glucose production. 2008 Diabetes pmid:18511848
Sakai H et al. Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine. 2008 J Smooth Muscle Res pmid:18480594
Alonso E et al. The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect. 2008 J. Cell. Biochem. pmid:18500723
Kim YH et al. Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. 2008 Diabetes pmid:18443201
Byun HS et al. Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase. 2008 Exp. Mol. Med. pmid:18446057
Lee JS et al. House dust mite, Dermatophagoides pteronissinus increases expression of MCP-1, IL-6, and IL-8 in human monocytic THP-1 cells. 2008 Cytokine pmid:18490175
Dreixler JC et al. Protein kinase C subtypes and retinal ischemic preconditioning. 2008 Exp. Eye Res. pmid:18722601
Kaur K et al. Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts. 2008 Biol. Pharm. Bull. pmid:18758070
Lim JH et al. Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells. 2008 Apoptosis pmid:18807195
Kojima K et al. Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues. 2008 Biochem. Biophys. Res. Commun. pmid:18789895