Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim MH et al. | EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. | 2017 | Toxicol. Appl. Pharmacol. | pmid:27939242 |
Juneja M et al. | Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. | 2017 | PLoS Biol. | pmid:28570591 |
Zhu Y et al. | Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. | 2017 | Oncotarget | pmid:28423559 |
Prudnikova TY and Chernoff J | The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. | 2017 | Small GTPases | pmid:27427770 |
Serrero M et al. | PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. | 2017 | Sci Rep | pmid:28539656 |
Guan X et al. | Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. | 2017 | Sci Rep | pmid:28165042 |
So KY and Oh SH | Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. | 2016 | Toxicology | pmid:27658547 |
Shin EJ et al. | Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. | 2016 | Arch. Toxicol. | pmid:25895139 |
Pandey S et al. | Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27498028 |
Lishmanov YB et al. | Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. | 2016 | Bull. Exp. Biol. Med. | pmid:27496038 |
Lee NR et al. | Cytokine secreted by S100A9 via TLR4 in monocytes delays neutrophil apoptosis by inhibition of caspase 9/3 pathway. | 2016 | Cytokine | pmid:27459393 |
Daveri E et al. | Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. | 2016 | Cancer Lett. | pmid:27343979 |
Woo SM et al. | Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells. | 2016 | Mol Med Rep | pmid:27222046 |
Liao TY et al. | Rottlerin impairs the formation and maintenance of psychostimulant-supported memory. | 2016 | Psychopharmacology (Berl.) | pmid:26960698 |
Yamaguchi R et al. | Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. | 2016 | Blood Cells Mol. Dis. | pmid:26852662 |
Berardi DE et al. | PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy. | 2016 | J. Cell. Biochem. | pmid:26335446 |
Wang L et al. | Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. | 2016 | Oncotarget | pmid:27626499 |
Yin X et al. | Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. | 2016 | Oncotarget | pmid:27582552 |
Oyedemi BO et al. | Novel R-plasmid conjugal transfer inhibitory and antibacterial activities of phenolic compounds from Mallotus philippensis (Lam.) Mull. Arg. | 2016 | J Glob Antimicrob Resist | pmid:27436460 |
Yang QE et al. | The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. | 2016 | Reprod. Fertil. Dev. | pmid:25116760 |