Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang L et al. | Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. | 2016 | Oncotarget | pmid:27626499 |
Mischitelli M et al. | Stimulation of Suicidal Erythrocyte Death by Rottlerin. | 2016 | Cell. Physiol. Biochem. | pmid:27889758 |
Xie L et al. | Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. | 2016 | PLoS ONE | pmid:27442243 |
Atef ME and Anand-Srivastava MB | Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. | 2016 | PLoS ONE | pmid:27379421 |
Satoh K et al. | Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26744470 |
Chen RC et al. | Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. | 2015 | Food Funct | pmid:25773745 |
Kawabata H et al. | A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. | 2015 | Exp. Hematol. | pmid:25633564 |
Hong KK et al. | The Mosaic of Rottlerin. | 2015 | J. Org. Chem. | pmid:26426936 |
Xu H et al. | Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. | 2015 | Pharmacology | pmid:26021525 |
Torricelli C et al. | Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. | 2015 | Cancer Lett. | pmid:25661734 |
Liao YF et al. | Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. | 2015 | Mol Med Rep | pmid:25650742 |
Mori N et al. | Activation of PKC-δ in HTLV-1-infected T cells. | 2015 | Int. J. Oncol. | pmid:25625567 |
Cordeiro B et al. | Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. | 2015 | Ann. Thorac. Surg. | pmid:25527424 |
Lin CC et al. | Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. | 2015 | Enzyme Microb. Technol. | pmid:25435499 |
Dang DK et al. | Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. | 2015 | Clin. Exp. Pharmacol. Physiol. | pmid:25400014 |
Tuorkey MJ | Cancer Therapy with Phytochemicals: Present and Future Perspectives. | 2015 | Biomed. Environ. Sci. | pmid:26695359 |
Huang SP et al. | Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. | 2015 | Dis Model Mech | pmid:26092127 |
Cordeiro B et al. | BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26071546 |
Faria CC et al. | Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. | 2015 | Oncotarget | pmid:26061748 |
Sheats MK et al. | In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. | 2015 | Inflammation | pmid:25515270 |