Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with rottlerin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li S et al. | Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes. | 2011 | Mol. Cell. Neurosci. | pmid:21708260 |
Jäntti MH et al. | OX1 orexin/hypocretin receptor activation of phospholipase D. | 2012 | Br. J. Pharmacol. | pmid:21718304 |
Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |
Tsai RK et al. | PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. | 2011 | Mol. Vis. | pmid:21738386 |
Lawal AO and Ellis EM | Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787730 |
Clements RT et al. | Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. | 2011 | Circulation | pmid:21911819 |
Bae JH et al. | Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction. | 2012 | Cancer Sci. | pmid:21951556 |
Lee YS and Choi EM | Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells. | 2012 | J. Oral Pathol. Med. | pmid:21958211 |
Park EJ and Kwon TK | Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. | 2011 | Exp. Mol. Med. | pmid:21971413 |
Chen Z et al. | Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. | 2011 | Endocr. Relat. Cancer | pmid:21990324 |
Koh YH et al. | Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. | 2012 | J. Cell. Mol. Med. | pmid:22040127 |
Lin W et al. | Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation. | 2012 | Eur J Med Chem | pmid:22093759 |
Wermuth PJ et al. | Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. | 2011 | PLoS ONE | pmid:22096525 |
Ku CS et al. | Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. | 2012 | J. Nutr. Biochem. | pmid:22209005 |
Deng B et al. | Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. | 2012 | J. Vasc. Res. | pmid:22261918 |
Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
Maioli E et al. | Rottlerin and cancer: novel evidence and mechanisms. | 2012 | ScientificWorldJournal | pmid:22272173 |
Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
Furuya T et al. | Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor. | 2012 | Curr. Eye Res. | pmid:22335803 |
Yun N et al. | Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning. | 2012 | J Physiol Sci | pmid:22359070 |
Lim JH et al. | Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism. | 2012 | Chem. Biol. Interact. | pmid:22410117 |
Hsu YC et al. | Ciliogenic RFX transcription factors regulate FGF1 gene promoter. | 2012 | J. Cell. Biochem. | pmid:22415835 |
Narumi K et al. | Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). | 2012 | Int J Pharm | pmid:22426323 |
Li Z et al. | Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. | 2012 | Oncol. Rep. | pmid:22427054 |
Latorre E et al. | Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. | 2012 | Mol. Cancer | pmid:22436134 |
Hsu JL et al. | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. | 2012 | Biochem. Pharmacol. | pmid:22490701 |
Shin EJ et al. | Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. | 2012 | Behav. Brain Res. | pmid:22512859 |
Guo D et al. | Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. | 2012 | Mol. Cell. Neurosci. | pmid:22521536 |
Contreras X et al. | Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. | 2012 | Retrovirology | pmid:22554282 |
Gonzalez-Garcia JR et al. | The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. | 2013 | J. Cell. Physiol. | pmid:22566126 |
Mendonça MC et al. | Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. | 2012 Sep-Oct | Vascul. Pharmacol. | pmid:22583821 |
Alapati K et al. | uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. | 2012 | Int. J. Oncol. | pmid:22641287 |
Kolasa E et al. | Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. | 2012 | Toxicol In Vitro | pmid:22643241 |
Yu HS et al. | Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. | 2013 | Prostate | pmid:22653778 |
Huang CY et al. | Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. | 2012 | Arthritis Rheum. | pmid:22674286 |
Haines RJ et al. | Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. | 2012 | J. Biol. Chem. | pmid:22696221 |
Xing AP et al. | Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. | 2012 | J. Biomed. Biotechnol. | pmid:22754279 |
Maioli E et al. | Rottlerin and curcumin: a comparative analysis. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22758638 |
Tcatchoff L et al. | Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. | 2012 | PLoS ONE | pmid:22792315 |
Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
Chen RX et al. | Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. | 2012 | Cell. Physiol. Biochem. | pmid:22832358 |
Singh BN et al. | Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. | 2012 | Biochem. Pharmacol. | pmid:22902833 |
Lei L et al. | Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). | 2012 | PLoS ONE | pmid:22970301 |
Chang WT et al. | Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells. | 2012 | Anticancer Res. | pmid:22993309 |
Song BW et al. | Protein kinase C activation stimulates mesenchymal stem cell adhesion through activation of focal adhesion kinase. | 2013 | Cell Transplant | pmid:23006313 |
Barrias ES et al. | Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cell. | 2012 | Microbes Infect. | pmid:23010292 |
Chen BR et al. | Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. | 2012 | PLoS ONE | pmid:23155470 |
Freebern WJ et al. | Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing. | 2013 Jan-Mar | J Immunotoxicol | pmid:23173903 |
Lin YM et al. | The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. | 2012 | PLoS ONE | pmid:23185512 |
Okuwa H et al. | Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase. | 2012 | Cell. Physiol. Biochem. | pmid:23221613 |
Kim YS et al. | Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells. | 2012 | PLoS ONE | pmid:23226259 |
Leppänen T et al. | Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. | 2013 | PLoS ONE | pmid:23326354 |
Lee SJ et al. | PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. | 2013 | PLoS ONE | pmid:23441159 |
Wang J et al. | PTPα-mediated Src activation by EGF in human breast cancer cells. | 2013 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:23532252 |
Meehan AC et al. | Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. | 2013 | PLoS ONE | pmid:23555904 |
Chan TK et al. | Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. | 2013 | Phytomedicine | pmid:23632085 |
Cristóvão AC et al. | PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23827392 |
Yun N and Lee SM | Activation of protein kinase C delta reduces hepatocellular damage in ischemic preconditioned rat liver. | 2013 | J. Surg. Res. | pmid:23932656 |
Khor EC et al. | Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. | 2013 | PLoS ONE | pmid:23951014 |
Goldklang MP et al. | Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. | 2013 | FASEB J. | pmid:23995289 |
Jain SK et al. | Semisynthesis of mallotus B from rottlerin: evaluation of cytotoxicity and apoptosis-inducing activity. | 2013 | J. Nat. Prod. | pmid:24041234 |
Sheean RK et al. | Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. | 2013 | Neuroscience | pmid:24095695 |
Kumar D et al. | Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. | 2014 | Cancer Lett. | pmid:24125861 |
Ashour AA et al. | Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. | 2014 | Apoptosis | pmid:24193916 |
Yang JH et al. | Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24211276 |
Pandur S et al. | Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression. | 2014 | Mol. Cell. Biochem. | pmid:24281857 |
Zhu S et al. | PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24289563 |
Kumar D et al. | Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms. | 2013 | Mol. Cancer | pmid:24359639 |
Fenyvesi F et al. | Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis. | 2014 | PLoS ONE | pmid:24416301 |
Hagelkruys A et al. | A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. | 2014 | Development | pmid:24449838 |
Lu W et al. | Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. | 2014 | Cell. Signal. | pmid:24607787 |
Liu ZC et al. | Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells. | 2014 | Mol Med Rep | pmid:24626810 |
Tiwari RL et al. | PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. | 2014 | J. Lipid Res. | pmid:24792928 |
Huang M et al. | Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. | 2014 | Cancer Lett. | pmid:25050737 |
Nobe K et al. | Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25085043 |
Naskar S et al. | Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. | 2014 | PLoS ONE | pmid:25116170 |
Yang QE et al. | The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. | 2016 | Reprod. Fertil. Dev. | pmid:25116760 |
Ashour AA et al. | Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. | 2014 | J. Cell. Mol. Med. | pmid:25215932 |
Szilagyi K et al. | PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. | 2014 | Cardiovasc. Res. | pmid:25253077 |
Chen Q et al. | PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. | 2014 | PLoS ONE | pmid:25350560 |
Song P et al. | PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. | 2014 | Oxid Med Cell Longev | pmid:25371776 |
Hasima N and Ozpolat B | Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. | 2014 | Cell Death Dis | pmid:25375374 |
Dang DK et al. | Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. | 2015 | Clin. Exp. Pharmacol. Physiol. | pmid:25400014 |
Lin CC et al. | Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. | 2015 | Enzyme Microb. Technol. | pmid:25435499 |
Sheats MK et al. | In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. | 2015 | Inflammation | pmid:25515270 |
Gangwar M et al. | Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. | 2014 | ScientificWorldJournal | pmid:25525615 |
Cordeiro B et al. | Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. | 2015 | Ann. Thorac. Surg. | pmid:25527424 |
Mori N et al. | Activation of PKC-δ in HTLV-1-infected T cells. | 2015 | Int. J. Oncol. | pmid:25625567 |
Kawabata H et al. | A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. | 2015 | Exp. Hematol. | pmid:25633564 |
Liao YF et al. | Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. | 2015 | Mol Med Rep | pmid:25650742 |
Torricelli C et al. | Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. | 2015 | Cancer Lett. | pmid:25661734 |
Chen RC et al. | Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. | 2015 | Food Funct | pmid:25773745 |
Shin EJ et al. | Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. | 2016 | Arch. Toxicol. | pmid:25895139 |
Xu H et al. | Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. | 2015 | Pharmacology | pmid:26021525 |
Faria CC et al. | Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. | 2015 | Oncotarget | pmid:26061748 |
Cordeiro B et al. | BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26071546 |
Huang SP et al. | Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. | 2015 | Dis Model Mech | pmid:26092127 |
Berardi DE et al. | PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy. | 2016 | J. Cell. Biochem. | pmid:26335446 |
Hong KK et al. | The Mosaic of Rottlerin. | 2015 | J. Org. Chem. | pmid:26426936 |
Tuorkey MJ | Cancer Therapy with Phytochemicals: Present and Future Perspectives. | 2015 | Biomed. Environ. Sci. | pmid:26695359 |