rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shoenfelt JL and Fenton MJ | TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent. | 2006 | J. Endotoxin Res. | pmid:16953975 |
| Gäreskog M and Wentzel P | N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. | 2007 | J. Endocrinol. | pmid:17210758 |
| Jimenez SA et al. | Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. | 2001 | J. Clin. Invest. | pmid:11696585 |
| Sumitomo M et al. | Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. | 2002 | J. Clin. Invest. | pmid:11901191 |
| Pabla N et al. | Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. | 2011 | J. Clin. Invest. | pmid:21633170 |
| Frank DE and Carter WG | Laminin 5 deposition regulates keratinocyte polarization and persistent migration. | 2004 | J. Cell. Sci. | pmid:14996912 |
| Hsu HY et al. | Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. | 2008 | J. Cell. Physiol. | pmid:18357586 |
| Hsieh HL et al. | BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. | 2006 | J. Cell. Physiol. | pmid:15991247 |
| Wu SN et al. | Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells. | 2007 | J. Cell. Physiol. | pmid:17133362 |
| Bankers-Fulbright JL et al. | Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta. | 2001 | J. Cell. Physiol. | pmid:11748588 |
| Gonzalez-Garcia JR et al. | The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. | 2013 | J. Cell. Physiol. | pmid:22566126 |
| Kudirka JC et al. | P2Y nucleotide receptor signaling through MAPK/ERK is regulated by extracellular matrix: involvement of beta3 integrins. | 2007 | J. Cell. Physiol. | pmid:17620283 |
| Koh YH et al. | Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. | 2011 | J. Cell. Mol. Med. | pmid:20973912 |
| Ashour AA et al. | Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. | 2014 | J. Cell. Mol. Med. | pmid:25215932 |
| Koh YH et al. | Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. | 2012 | J. Cell. Mol. Med. | pmid:22040127 |
| Kim YH et al. | Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C-delta (PKC-delta) signal pathway. | 2007 | J. Cell. Biochem. | pmid:17407153 |
| Löber K et al. | STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816. | 2008 | J. Cell. Biochem. | pmid:17615556 |
| Berardi DE et al. | PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy. | 2016 | J. Cell. Biochem. | pmid:26335446 |
| Hughes PJ et al. | Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. | 2006 | J. Cell. Biochem. | pmid:16178010 |
| Zhang J et al. | PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. | 2005 | J. Cell. Biochem. | pmid:16114000 |
| Wen HC and Lin WW | Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells. | 2000 | J. Cell. Biochem. | pmid:10996851 |
| Scott DW and Loo G | Curcumin-induced GADD153 upregulation: modulation by glutathione. | 2007 | J. Cell. Biochem. | pmid:17171638 |
| Alonso E et al. | The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect. | 2008 | J. Cell. Biochem. | pmid:18500723 |
| Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
| Hsu YC et al. | Ciliogenic RFX transcription factors regulate FGF1 gene promoter. | 2012 | J. Cell. Biochem. | pmid:22415835 |
| Di Rosa M et al. | Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. | 2009 | J. Cell. Biochem. | pmid:19415692 |
| Lin CJ et al. | Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex. | 2010 | J. Cell. Biochem. | pmid:20225271 |
| Di Baldassarre A et al. | Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching. | 2007 | J. Cell. Biochem. | pmid:17212360 |
| Xing AP et al. | Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. | 2012 | J. Biomed. Biotechnol. | pmid:22754279 |
| Maioli E et al. | Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells. | 2009 | J. Biomed. Biotechnol. | pmid:20168983 |
| Todt JC et al. | Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. | 2002 | J. Biol. Chem. | pmid:12114511 |
| Han JM et al. | Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. | 2002 | J. Biol. Chem. | pmid:11744693 |
| Li B et al. | Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. | 2002 | J. Biol. Chem. | pmid:11796722 |
| Vancurova I et al. | NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha. | 2001 | J. Biol. Chem. | pmid:11274209 |
| Hurbin A et al. | Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. | 2005 | J. Biol. Chem. | pmid:15767261 |
| Amos S et al. | Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. | 2005 | J. Biol. Chem. | pmid:15618223 |
| Tan M et al. | Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. | 2003 | J. Biol. Chem. | pmid:12431976 |
| Kim HJ et al. | The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. | 2003 | J. Biol. Chem. | pmid:12403780 |
| Saito S et al. | Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. | 2002 | J. Biol. Chem. | pmid:12226102 |
| Matthews V et al. | Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). | 2003 | J. Biol. Chem. | pmid:12832423 |
| Cummings R et al. | Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. | 2004 | J. Biol. Chem. | pmid:15280372 |
| Zhao KW et al. | Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. | 2005 | J. Biol. Chem. | pmid:16260419 |
| Efimova T and Eckert RL | Regulation of human involucrin promoter activity by novel protein kinase C isoforms. | 2000 | J. Biol. Chem. | pmid:10636851 |
| Ham YM et al. | The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. | 2003 | J. Biol. Chem. | pmid:14514687 |
| Ryazanova LV et al. | Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. | 2004 | J. Biol. Chem. | pmid:14594813 |
| Blois JT et al. | B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta. | 2004 | J. Biol. Chem. | pmid:15138267 |
| Haines RJ et al. | Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. | 2012 | J. Biol. Chem. | pmid:22696221 |
| Esper RM and Loeb JA | Neurotrophins induce neuregulin release through protein kinase Cdelta activation. | 2009 | J. Biol. Chem. | pmid:19648576 |
| Lanaspa MA et al. | The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. | 2010 | J. Biol. Chem. | pmid:20639513 |
| Chen N et al. | Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. | 1999 | J. Biol. Chem. | pmid:10336426 |