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Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. |
2019 |
In Vitro Cell. Dev. Biol. Anim. |
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Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. |
2019 |
Chem. Biol. Interact. |
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Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. |
2018 |
Biochem. Biophys. Res. Commun. |
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2018 |
Int J Mol Sci |
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In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. |
2018 |
Biochim. Biophys. Acta |
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Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus. |
2018 |
Virol. J. |
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Rottlerin inhibits cell growth, induces apoptosis and cell cycle arrest, and inhibits cell invasion in human hepatocellular carcinoma. |
2018 |
Mol Med Rep |
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Relaxin Inhibits Cardiac Fibrosis in Diabetic Rats: Roles of Protein Kinase Cδ. |
2018 |
Exp. Clin. Endocrinol. Diabetes |
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Unexpected dose response of HaCaT to UVB irradiation. |
2018 |
In Vitro Cell. Dev. Biol. Anim. |
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Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines. |
2018 |
Mol Med Rep |
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Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. |
2018 |
Biochim Biophys Acta Mol Basis Dis |
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PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. |
2018 |
Mol. Neurobiol. |
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EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. |
2017 |
Toxicol. Appl. Pharmacol. |
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Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. |
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Antiviral Res. |
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Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies. |
2017 |
PLoS ONE |
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Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. |
2017 |
Photodiagnosis Photodyn Ther |
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Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. |
2017 |
Oncotarget |
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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. |
2017 |
PLoS Biol. |
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Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. |
2017 |
Oncotarget |
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Intermittent Administration of Parathyroid Hormone 1-34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. |
2017 |
Int J Mol Sci |
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Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells. |
2017 |
Int. J. Oncol. |
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Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. |
2017 |
Cancer Biomark |
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Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. |
2017 |
Sci Rep |
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The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. |
2017 |
Small GTPases |
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PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. |
2017 |
Sci Rep |
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Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. |
2017 |
Sci Rep |
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Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. |
2016 |
Toxicology |
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Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. |
2016 |
Arch. Toxicol. |
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Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. |
2016 |
Biochem. Biophys. Res. Commun. |
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Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. |
2016 |
Bull. Exp. Biol. Med. |
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Cytokine secreted by S100A9 via TLR4 in monocytes delays neutrophil apoptosis by inhibition of caspase 9/3 pathway. |
2016 |
Cytokine |
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Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. |
2016 |
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Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells. |
2016 |
Mol Med Rep |
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Rottlerin impairs the formation and maintenance of psychostimulant-supported memory. |
2016 |
Psychopharmacology (Berl.) |
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Yamaguchi R et al. |
Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. |
2016 |
Blood Cells Mol. Dis. |
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PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy. |
2016 |
J. Cell. Biochem. |
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Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. |
2016 |
Oncotarget |
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Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. |
2016 |
Oncotarget |
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The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. |
2016 |
Cell. Physiol. Biochem. |
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Stimulation of Suicidal Erythrocyte Death by Rottlerin. |
2016 |
Cell. Physiol. Biochem. |
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Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. |
2016 |
PLoS ONE |
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Atef ME and Anand-Srivastava MB |
Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. |
2016 |
PLoS ONE |
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Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini. |
2016 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
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Novel R-plasmid conjugal transfer inhibitory and antibacterial activities of phenolic compounds from Mallotus philippensis (Lam.) Mull. Arg. |
2016 |
J Glob Antimicrob Resist |
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The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. |
2016 |
Reprod. Fertil. Dev. |
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Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. |
2015 |
Food Funct |
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A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. |
2015 |
Exp. Hematol. |
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The Mosaic of Rottlerin. |
2015 |
J. Org. Chem. |
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Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. |
2015 |
Pharmacology |
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Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. |
2015 |
Cancer Lett. |
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Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. |
2015 |
Mol Med Rep |
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Activation of PKC-δ in HTLV-1-infected T cells. |
2015 |
Int. J. Oncol. |
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Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. |
2015 |
Ann. Thorac. Surg. |
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Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. |
2015 |
Enzyme Microb. Technol. |
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Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. |
2015 |
Clin. Exp. Pharmacol. Physiol. |
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Tuorkey MJ |
Cancer Therapy with Phytochemicals: Present and Future Perspectives. |
2015 |
Biomed. Environ. Sci. |
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Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. |
2015 |
Dis Model Mech |
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BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion. |
2015 |
Am. J. Physiol. Heart Circ. Physiol. |
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Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. |
2015 |
Oncotarget |
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In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. |
2015 |
Inflammation |
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PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. |
2014 |
J. Lipid Res. |
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PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. |
2014 |
Cardiovasc. Res. |
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Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. |
2014 |
Toxicol. Appl. Pharmacol. |
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Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. |
2014 |
ScientificWorldJournal |
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Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. |
2014 |
Cell Death Dis |
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PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. |
2014 |
Oxid Med Cell Longev |
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PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. |
2014 |
PLoS ONE |
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Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. |
2014 |
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Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. |
2014 |
PLoS ONE |
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Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse. |
2014 |
J. Pharmacol. Exp. Ther. |
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Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. |
2014 |
Cell. Signal. |
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Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. |
2014 |
Apoptosis |
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Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression. |
2014 |
Mol. Cell. Biochem. |
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Hagelkruys A et al. |
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. |
2014 |
Development |
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Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis. |
2014 |
PLoS ONE |
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Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. |
2014 |
Cancer Lett. |
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Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells. |
2014 |
Mol Med Rep |
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Huang M et al. |
Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. |
2014 |
Cancer Lett. |
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Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing. |
2013 Jan-Mar |
J Immunotoxicol |
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Sheean RK et al. |
Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. |
2013 |
Neuroscience |
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The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. |
2013 |
J. Cell. Physiol. |
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PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. |
2013 |
Asian Pac. J. Cancer Prev. |
pmid:24289563
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Yu HS et al. |
Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. |
2013 |
Prostate |
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Cristóvão AC et al. |
PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. |
2013 |
Biochem. Biophys. Res. Commun. |
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Chan TK et al. |
Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. |
2013 |
Phytomedicine |
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Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. |
2013 |
PLoS ONE |
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Song BW et al. |
Protein kinase C activation stimulates mesenchymal stem cell adhesion through activation of focal adhesion kinase. |
2013 |
Cell Transplant |
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PTPα-mediated Src activation by EGF in human breast cancer cells. |
2013 |
Acta Biochim. Biophys. Sin. (Shanghai) |
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Meehan AC et al. |
Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. |
2013 |
PLoS ONE |
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Lee SJ et al. |
PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. |
2013 |
PLoS ONE |
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Yun N and Lee SM |
Activation of protein kinase C delta reduces hepatocellular damage in ischemic preconditioned rat liver. |
2013 |
J. Surg. Res. |
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Khor EC et al. |
Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. |
2013 |
PLoS ONE |
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Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. |
2013 |
FASEB J. |
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Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms. |
2013 |
Mol. Cancer |
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Semisynthesis of mallotus B from rottlerin: evaluation of cytotoxicity and apoptosis-inducing activity. |
2013 |
J. Nat. Prod. |
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Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. |
2012 Sep-Oct |
Vascul. Pharmacol. |
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Haines RJ et al. |
Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. |
2012 |
J. Biol. Chem. |
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Huang CY et al. |
Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. |
2012 |
Arthritis Rheum. |
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Alapati K et al. |
uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. |
2012 |
Int. J. Oncol. |
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Kolasa E et al. |
Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. |
2012 |
Toxicol In Vitro |
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