rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Maurya AK and Vinayak M Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. 2019 In Vitro Cell. Dev. Biol. Anim. pmid:30413935
Mai HN et al. Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. 2019 Chem. Biol. Interact. pmid:30393195
Wang Z et al. Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. 2018 Biochem. Biophys. Res. Commun. pmid:29203243
Nagai N et al. Involvement of Endocytosis in the Transdermal Penetration Mechanism of Ketoprofen Nanoparticles. 2018 Int J Mol Sci pmid:30041452
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Wang H et al. Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus. 2018 Virol. J. pmid:29793525
Shi J et al. Rottlerin inhibits cell growth, induces apoptosis and cell cycle arrest, and inhibits cell invasion in human hepatocellular carcinoma. 2018 Mol Med Rep pmid:29115596
Wang P et al. Relaxin Inhibits Cardiac Fibrosis in Diabetic Rats: Roles of Protein Kinase Cδ. 2018 Exp. Clin. Endocrinol. Diabetes pmid:28895644
Chang RS et al. Unexpected dose response of HaCaT to UVB irradiation. 2018 In Vitro Cell. Dev. Biol. Anim. pmid:30083841
Song J et al. Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines. 2018 Mol Med Rep pmid:30015872
Chao H et al. Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. 2018 Biochim Biophys Acta Mol Basis Dis pmid:29894755
Tran HQ et al. PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. 2018 Mol. Neurobiol. pmid:29468562
Kim MH et al. EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. 2017 Toxicol. Appl. Pharmacol. pmid:27939242
Abdelnabi R et al. Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. 2017 Antiviral Res. pmid:28039020
Min M et al. Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies. 2017 PLoS ONE pmid:29272319
Misuth M et al. Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. 2017 Photodiagnosis Photodyn Ther pmid:28373118
Zhao Z et al. Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. 2017 Oncotarget pmid:27999199
Juneja M et al. Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. 2017 PLoS Biol. pmid:28570591
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Kuo SW et al. Intermittent Administration of Parathyroid Hormone 1-34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. 2017 Int J Mol Sci pmid:29064396
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Sun S et al. Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. 2017 Cancer Biomark pmid:29036789
Ietta F et al. Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. 2017 Sci Rep pmid:28455500
Prudnikova TY and Chernoff J The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. 2017 Small GTPases pmid:27427770
Serrero M et al. PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. 2017 Sci Rep pmid:28539656
Guan X et al. Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. 2017 Sci Rep pmid:28165042
So KY and Oh SH Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. 2016 Toxicology pmid:27658547
Shin EJ et al. Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. 2016 Arch. Toxicol. pmid:25895139
Pandey S et al. Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. 2016 Biochem. Biophys. Res. Commun. pmid:27498028
Lishmanov YB et al. Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. 2016 Bull. Exp. Biol. Med. pmid:27496038
Lee NR et al. Cytokine secreted by S100A9 via TLR4 in monocytes delays neutrophil apoptosis by inhibition of caspase 9/3 pathway. 2016 Cytokine pmid:27459393
Daveri E et al. Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. 2016 Cancer Lett. pmid:27343979
Woo SM et al. Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells. 2016 Mol Med Rep pmid:27222046
Liao TY et al. Rottlerin impairs the formation and maintenance of psychostimulant-supported memory. 2016 Psychopharmacology (Berl.) pmid:26960698
Yamaguchi R et al. Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. 2016 Blood Cells Mol. Dis. pmid:26852662
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Wang L et al. Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. 2016 Oncotarget pmid:27626499
Yin X et al. Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. 2016 Oncotarget pmid:27582552
Matschke V et al. The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. 2016 Cell. Physiol. Biochem. pmid:27997884
Mischitelli M et al. Stimulation of Suicidal Erythrocyte Death by Rottlerin. 2016 Cell. Physiol. Biochem. pmid:27889758
Xie L et al. Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. 2016 PLoS ONE pmid:27442243
Atef ME and Anand-Srivastava MB Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. 2016 PLoS ONE pmid:27379421
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Oyedemi BO et al. Novel R-plasmid conjugal transfer inhibitory and antibacterial activities of phenolic compounds from Mallotus philippensis (Lam.) Mull. Arg. 2016 J Glob Antimicrob Resist pmid:27436460
Yang QE et al. The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. 2016 Reprod. Fertil. Dev. pmid:25116760
Chen RC et al. Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. 2015 Food Funct pmid:25773745
Kawabata H et al. A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. 2015 Exp. Hematol. pmid:25633564
Hong KK et al. The Mosaic of Rottlerin. 2015 J. Org. Chem. pmid:26426936
Xu H et al. Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. 2015 Pharmacology pmid:26021525
Torricelli C et al. Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. 2015 Cancer Lett. pmid:25661734
Liao YF et al. Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. 2015 Mol Med Rep pmid:25650742
Mori N et al. Activation of PKC-δ in HTLV-1-infected T cells. 2015 Int. J. Oncol. pmid:25625567
Cordeiro B et al. Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. 2015 Ann. Thorac. Surg. pmid:25527424
Lin CC et al. Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. 2015 Enzyme Microb. Technol. pmid:25435499
Dang DK et al. Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. 2015 Clin. Exp. Pharmacol. Physiol. pmid:25400014
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Tiwari RL et al. PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. 2014 J. Lipid Res. pmid:24792928
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Lu W et al. Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. 2014 Cell. Signal. pmid:24607787
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Pandur S et al. Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression. 2014 Mol. Cell. Biochem. pmid:24281857
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Kumar D et al. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. 2014 Cancer Lett. pmid:24125861
Liu ZC et al. Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells. 2014 Mol Med Rep pmid:24626810
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