| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Chantara W et al. | Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. | J Appl Toxicol | pmid:17080406 | |
| BACKHOUSE T and McGOOKIN A | Rottlerin; the synthesis of tetrahydrorottlerin and of tetrahydroallorottlerin and the reversibility of the rottlerone change. | 1948 | J Chem Soc | pmid:18906365 |
| Gschwendt M et al. | Rottlerin, a novel protein kinase inhibitor. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8123051 |
| Gschwendt M et al. | Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. | 1994 | FEBS Lett. | pmid:8307162 |
| Liedtke CM and Cole T | Antisense oligodeoxynucleotide to PKC-delta blocks alpha 1-adrenergic activation of Na-K-2Cl cotransport. | 1997 | Am. J. Physiol. | pmid:9374649 |
| Keenan C et al. | Isoform specificity of activators and inhibitors of protein kinase C gamma and delta. | 1997 | FEBS Lett. | pmid:9326378 |
| Parmer TG et al. | Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. | 1997 | Cell Growth Differ. | pmid:9056675 |
| Braiman L et al. | Protein kinase Cdelta mediates insulin-induced glucose transport in primary cultures of rat skeletal muscle. | 1999 | Mol. Endocrinol. | pmid:10598577 |
| Song JC et al. | PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS. | 1999 | Am. J. Physiol. | pmid:10600776 |
| Samokhin GP et al. | Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets. | 1999 | Eur. J. Pharmacol. | pmid:10618482 |
| Palmer TM and Stiles GL | Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. | 1999 | Biochemistry | pmid:10555965 |
| Villalba M et al. | Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death. | 1999 | J. Immunol. | pmid:10570264 |
| Bheekha-Escura R et al. | Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor. | 1999 | J. Allergy Clin. Immunol. | pmid:10329832 |
| Corbit KC et al. | Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells. | 1999 | Mol. Cell. Biol. | pmid:10330161 |
| Chen N et al. | Translocation of protein kinase Cepsilon and protein kinase Cdelta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. | 1999 | J. Biol. Chem. | pmid:10336426 |
| Basu A and Akkaraju GR | Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. | 1999 | Biochemistry | pmid:10194341 |
| Hornia A et al. | Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. | 1999 | Mol. Cell. Biol. | pmid:10523655 |
| Reyland ME et al. | Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. | 1999 | J. Biol. Chem. | pmid:10383415 |
| Efimova T and Eckert RL | Regulation of human involucrin promoter activity by novel protein kinase C isoforms. | 2000 | J. Biol. Chem. | pmid:10636851 |
| Cross T et al. | PKC-delta is an apoptotic lamin kinase. | 2000 | Oncogene | pmid:10822384 |
| Peters CA et al. | Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. | 2000 | Mol. Endocrinol. | pmid:10770494 |
| Kilpatrick LE et al. | Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078718 |
| Lee SD et al. | Bradykinin activates phospholipase D2 via protein kinase cdelta in PC12 cells. | 2000 | Neurosci. Lett. | pmid:11058804 |
| Wert MM and Palfrey HC | Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. | 2000 | Biochem. J. | pmid:11062070 |
| Chen NY et al. | Activation of PKC is required for arsenite-induced signal transduction. | 2000 | J. Environ. Pathol. Toxicol. Oncol. | pmid:10983896 |
| Wen HC and Lin WW | Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells. | 2000 | J. Cell. Biochem. | pmid:10996851 |
| Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
| Gallagher HC et al. | Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. | 2000 | J. Neurosci. Res. | pmid:10972960 |
| Cho SI et al. | Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. | 2000 | Biochim. Biophys. Acta | pmid:10913818 |
| Kontny E et al. | Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. | 2000 | J. Leukoc. Biol. | pmid:10670587 |
| Alexander SR et al. | Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils. | 2000 | J. Leukoc. Biol. | pmid:10733103 |
| Davies SP et al. | Specificity and mechanism of action of some commonly used protein kinase inhibitors. | 2000 | Biochem. J. | pmid:10998351 |
| Fryer RM et al. | Essential activation of PKC-delta in opioid-initiated cardioprotection. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179083 |
| De Witt BJ et al. | Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133494 |
| Takahashi T and Shibuya M | The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162532 |
| Masur K et al. | High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. | 2001 | Mol. Biol. Cell | pmid:11451996 |
| Jackson TA et al. | Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta. | 2001 | Mol. Endocrinol. | pmid:11518800 |
| Soltoff SP | Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation. | 2001 | J. Biol. Chem. | pmid:11498535 |
| Leitges M et al. | Rottlerin-independent attenuation of pervanadate-induced tyrosine phosphorylation events by protein kinase C-delta in hemopoietic cells. | 2001 | Lab. Invest. | pmid:11502860 |
| Chen JH et al. | Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11749125 |
| Wang GY et al. | Protein kinase C-epsilon is a trigger of delayed cardioprotection against myocardial ischemia of kappa-opioid receptor stimulation in rat ventricular myocytes. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11602672 |
| Vancurova I et al. | NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha. | 2001 | J. Biol. Chem. | pmid:11274209 |
| Solomou EE et al. | Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. | 2001 | J. Immunol. | pmid:11313407 |
| Morino K et al. | Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta. | 2001 | Endocrinology | pmid:11356718 |
| Braiman L et al. | Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle. | 2001 | Mol. Endocrinol. | pmid:11266508 |
| Leung CH et al. | PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11444839 |
| Dietrich C et al. | Rottlerin induces a transformed phenotype in human keratinocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401499 |
| Noya F et al. | p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7. | 2001 | J. Virol. | pmid:11390614 |
| Chen JS and Song JG | Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells. | 2001 | IUBMB Life | pmid:11419696 |