| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Mai HN et al. | Protein kinase Cδ knockout mice are protected from cocaine-induced hepatotoxicity. | 2019 | Chem. Biol. Interact. | pmid:30393195 |
| Wang Z et al. | Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29203243 |
| Nagai N et al. | Involvement of Endocytosis in the Transdermal Penetration Mechanism of Ketoprofen Nanoparticles. | 2018 | Int J Mol Sci | pmid:30041452 |
| Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
| Wang H et al. | Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus. | 2018 | Virol. J. | pmid:29793525 |
| Shi J et al. | Rottlerin inhibits cell growth, induces apoptosis and cell cycle arrest, and inhibits cell invasion in human hepatocellular carcinoma. | 2018 | Mol Med Rep | pmid:29115596 |
| Wang P et al. | Relaxin Inhibits Cardiac Fibrosis in Diabetic Rats: Roles of Protein Kinase Cδ. | 2018 | Exp. Clin. Endocrinol. Diabetes | pmid:28895644 |
| Chang RS et al. | Unexpected dose response of HaCaT to UVB irradiation. | 2018 | In Vitro Cell. Dev. Biol. Anim. | pmid:30083841 |
| Song J et al. | Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines. | 2018 | Mol Med Rep | pmid:30015872 |
| Chao H et al. | Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. | 2018 | Biochim Biophys Acta Mol Basis Dis | pmid:29894755 |
| Tran HQ et al. | PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT Receptor and Upregulation of Nrf2-Dependent GSH Synthesis. | 2018 | Mol. Neurobiol. | pmid:29468562 |
| Kim MH et al. | EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. | 2017 | Toxicol. Appl. Pharmacol. | pmid:27939242 |
| Abdelnabi R et al. | Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. | 2017 | Antiviral Res. | pmid:28039020 |
| Min M et al. | Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies. | 2017 | PLoS ONE | pmid:29272319 |
| Misuth M et al. | Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation. | 2017 | Photodiagnosis Photodyn Ther | pmid:28373118 |
| Zhao Z et al. | Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer. | 2017 | Oncotarget | pmid:27999199 |
| Juneja M et al. | Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1. | 2017 | PLoS Biol. | pmid:28570591 |
| Zhu Y et al. | Rottlerin as a novel chemotherapy agent for adrenocortical carcinoma. | 2017 | Oncotarget | pmid:28423559 |
| Kuo SW et al. | Intermittent Administration of Parathyroid Hormone 1-34 Enhances Osteogenesis of Human Mesenchymal Stem Cells by Regulating Protein Kinase Cδ. | 2017 | Int J Mol Sci | pmid:29064396 |
| Wang X et al. | Dual action of NSC606985 on cell growth and apoptosis mediated through PKCδ in prostatic cancer cells. | 2017 | Int. J. Oncol. | pmid:29048618 |
| Sun S et al. | Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. | 2017 | Cancer Biomark | pmid:29036789 |
| Ietta F et al. | Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. | 2017 | Sci Rep | pmid:28455500 |
| Prudnikova TY and Chernoff J | The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. | 2017 | Small GTPases | pmid:27427770 |
| Serrero M et al. | PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. | 2017 | Sci Rep | pmid:28539656 |
| Guan X et al. | Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. | 2017 | Sci Rep | pmid:28165042 |
| So KY and Oh SH | Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells. | 2016 | Toxicology | pmid:27658547 |
| Shin EJ et al. | Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. | 2016 | Arch. Toxicol. | pmid:25895139 |
| Pandey S et al. | Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27498028 |
| Lishmanov YB et al. | Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. | 2016 | Bull. Exp. Biol. Med. | pmid:27496038 |
| Lee NR et al. | Cytokine secreted by S100A9 via TLR4 in monocytes delays neutrophil apoptosis by inhibition of caspase 9/3 pathway. | 2016 | Cytokine | pmid:27459393 |
| Daveri E et al. | Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. | 2016 | Cancer Lett. | pmid:27343979 |
| Woo SM et al. | Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells. | 2016 | Mol Med Rep | pmid:27222046 |
| Liao TY et al. | Rottlerin impairs the formation and maintenance of psychostimulant-supported memory. | 2016 | Psychopharmacology (Berl.) | pmid:26960698 |
| Yamaguchi R et al. | Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. | 2016 | Blood Cells Mol. Dis. | pmid:26852662 |
| Berardi DE et al. | PKCδ Inhibition Impairs Mammary Cancer Proliferative Capacity But Selects Cancer Stem Cells, Involving Autophagy. | 2016 | J. Cell. Biochem. | pmid:26335446 |
| Wang L et al. | Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells. | 2016 | Oncotarget | pmid:27626499 |
| Yin X et al. | Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells. | 2016 | Oncotarget | pmid:27582552 |
| Matschke V et al. | The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. | 2016 | Cell. Physiol. Biochem. | pmid:27997884 |
| Mischitelli M et al. | Stimulation of Suicidal Erythrocyte Death by Rottlerin. | 2016 | Cell. Physiol. Biochem. | pmid:27889758 |
| Xie L et al. | Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. | 2016 | PLoS ONE | pmid:27442243 |
| Atef ME and Anand-Srivastava MB | Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. | 2016 | PLoS ONE | pmid:27379421 |
| Satoh K et al. | Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:26744470 |
| Oyedemi BO et al. | Novel R-plasmid conjugal transfer inhibitory and antibacterial activities of phenolic compounds from Mallotus philippensis (Lam.) Mull. Arg. | 2016 | J Glob Antimicrob Resist | pmid:27436460 |
| Yang QE et al. | The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. | 2016 | Reprod. Fertil. Dev. | pmid:25116760 |
| Hong KK et al. | The Mosaic of Rottlerin. | 2015 | J. Org. Chem. | pmid:26426936 |
| Xu H et al. | Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. | 2015 | Pharmacology | pmid:26021525 |
| Torricelli C et al. | Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. | 2015 | Cancer Lett. | pmid:25661734 |
| Liao YF et al. | Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. | 2015 | Mol Med Rep | pmid:25650742 |
| Mori N et al. | Activation of PKC-δ in HTLV-1-infected T cells. | 2015 | Int. J. Oncol. | pmid:25625567 |