rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Shirasugi I et al. Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. 2010 Biosci. Biotechnol. Biochem. pmid:21071833
Wang Y et al. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct. 2010 Am. J. Physiol. Renal Physiol. pmid:20861079
Tang CH et al. The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. 2010 Arthritis Rheum. pmid:20862675
Xie MJ et al. Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ. 2010 Clin. Exp. Pharmacol. Physiol. pmid:20880184
Jiang W et al. [Role of protein kinase C-delta in hyperthermia-induced apoptosis in tongue squamous cell carcinoma Tca8113 cells]. 2010 Hua Xi Kou Qiang Yi Xue Za Zhi pmid:21179694
Arisaka M et al. Involvement of protein kinase Cdelta in induction of apoptosis by cationic liposomes in macrophage-like RAW264.7 cells. 2010 FEBS Lett. pmid:20122929
Wallerstedt E et al. Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells. 2010 Diabetologia pmid:20151299
Liu J et al. The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells. 2010 J Tissue Eng Regen Med pmid:20033927
Shumilina E et al. Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. 2010 Cell. Physiol. Biochem. pmid:21063107
Lee HG and Yang JH PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner. 2010 Chemosphere pmid:20846705
Mok SA et al. A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures. 2009 Cell Res. pmid:19188931
Doller A et al. Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R. 2009 Am. J. Pathol. pmid:19246637
Kurosu T et al. Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. 2009 Cancer Res. pmid:19366808
Satoh K et al. Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19372103
Lima F et al. Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. 2009 Mol. Biol. Cell pmid:19339281
Raghu H et al. Kaposi's sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells. 2009 J. Virol. pmid:19279100
Coan KE et al. Promiscuous aggregate-based inhibitors promote enzyme unfolding. 2009 J. Med. Chem. pmid:19281222
Choi YA et al. Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells. 2009 Biochimie pmid:19306958
Kato K et al. Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19837952
Rohilla A and Balakumar P The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta. 2009 Biomed. Pharmacother. pmid:19914793