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Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. |
2003 |
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Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes. |
2003 |
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Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. |
2003 |
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Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. |
2003 |
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Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). |
2003 |
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Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain. |
2003 Mar-Apr |
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Activation of protein kinase C delta by IFN-gamma. |
2003 |
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Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart. |
2003 |
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Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. |
2003 |
Neuroscience |
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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). |
2003 |
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Rottlerin, an inhibitor of protein kinase Cdelta (PKCdelta), inhibits astrocytic glutamate transport activity and reduces GLAST immunoreactivity by a mechanism that appears to be PKCdelta-independent. |
2003 |
J. Neurochem. |
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Effect of detergent on "promiscuous" inhibitors. |
2003 |
J. Med. Chem. |
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Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. |
2003 |
Arch. Biochem. Biophys. |
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Role of PKC-delta activity in glutathione-depleted neuroblastoma cells. |
2003 |
Free Radic. Biol. Med. |
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Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. |
2003 |
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2003 |
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. |
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2003 |
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Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B. |
2003 |
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Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism. |
2003 |
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A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. |
2003 |
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Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel. |
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IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCdelta. |
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2003 |
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Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF-induced phosphorylation of MEK and ERK. |
2004 |
Am. J. Physiol. Heart Circ. Physiol. |
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Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. |
2004 |
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Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. |
2004 |
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2004 |
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Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. |
2004 |
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Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells. |
2004 |
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PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. |
2004 |
Am. J. Physiol. Heart Circ. Physiol. |
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Laminin 5 deposition regulates keratinocyte polarization and persistent migration. |
2004 |
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2003 |
J Enzyme Inhib Med Chem |
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Down-regulation of Bcl-2 is associated with cisplatin resistance in human small cell lung cancer H69 cells. |
2004 |
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B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta. |
2004 |
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Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. |
2004 |
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Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. |
2004 |
J. Invest. Dermatol. |
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Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. |
2004 |
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Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. |
2004 |
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Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. |
2004 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
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Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. |
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Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. |
2004 |
Mol. Cells |
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Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. |
2004 |
J. Pharmacol. Exp. Ther. |
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Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. |
2004 |
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Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. |
2004 |
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Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. |
2004 |
Mol. Cell. Biol. |
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Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. |
2004 |
J. Virol. |
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Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. |
2004 |
Mol. Biol. Cell |
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The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. |
2004 |
Biochem. Biophys. Res. Commun. |
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A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. |
2004 |
Biochem. Biophys. Res. Commun. |
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IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. |
2004 |
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VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Lewis AE et al. |
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. |
2005 |
Cell. Signal. |
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Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. |
2004 |
J. Immunol. |
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Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
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Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. |
2004 |
Anesth. Analg. |
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Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. |
2005 |
Oncogene |
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Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. |
2004 |
J. Immunol. |
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Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. |
2005 |
Mol. Biol. Cell |
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Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. |
2005 |
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Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. |
2005 Jan-Feb |
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Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. |
2005 |
J. Immunol. |
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Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. |
2005 |
Diabetes |
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Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. |
2004 |
Ann. N. Y. Acad. Sci. |
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Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. |
2005 |
FEBS J. |
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Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. |
2005 |
Cancer Chemother. Pharmacol. |
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Nabha SM et al. |
Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. |
2005 |
Oncogene |
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Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. |
2005 |
Free Radic. Biol. Med. |
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Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. |
2005 |
J. Biol. Chem. |
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Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. |
2005 |
Brain |
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Miguel BG et al. |
Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. |
2005 |
Biochim. Biophys. Acta |
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Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. |
2005 |
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A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. |
2005 |
Mol. Cell. Biol. |
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PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. |
2005 |
Biochem. J. |
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Panaretakis T et al. |
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. |
2005 |
Mol. Biol. Cell |
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The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. |
2005 |
Life Sci. |
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PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. |
2005 |
Cardiovasc. Res. |
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Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. |
2005 |
J. Steroid Biochem. Mol. Biol. |
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Avila GE et al. |
Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. |
2005 |
J. Pharmacol. Exp. Ther. |
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Hsieh HL et al. |
BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. |
2006 |
J. Cell. Physiol. |
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Activation of the BK (SLO1) potassium channel by mallotoxin. |
2005 |
J. Biol. Chem. |
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Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells. |
2005 |
Eur. J. Pharmacol. |
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Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. |
2005 |
Cancer Chemother. Pharmacol. |
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Brown JM et al. |
Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. |
2005 |
J. Cell. Biochem. |
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Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. |
2006 |
Atherosclerosis |
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Hughes PJ et al. |
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. |
2006 |
J. Cell. Biochem. |
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Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. |
2005 |
Biochem. Biophys. Res. Commun. |
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Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. |
2005 |
Neurochem. Int. |
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Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. |
2005 |
FEBS Lett. |
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Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. |
2005 |
J. Interferon Cytokine Res. |
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Wung BS et al. |
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. |
2006 |
Pharmacol. Res. |
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Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. |
2006 |
Int. J. Biochem. Cell Biol. |
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Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. |
2005 |
J. Biol. Chem. |
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Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
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Oh JI et al. |
Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. |
2005 |
Cancer Lett. |
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Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells. |
2005 |
Immunology |
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NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. |
2005 |
EMBO J. |
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