| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen RC et al. | Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. | 2015 | Food Funct | pmid:25773745 |
| Kawabata H et al. | A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. | 2015 | Exp. Hematol. | pmid:25633564 |
| Hong KK et al. | The Mosaic of Rottlerin. | 2015 | J. Org. Chem. | pmid:26426936 |
| Xu H et al. | Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. | 2015 | Pharmacology | pmid:26021525 |
| Torricelli C et al. | Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. | 2015 | Cancer Lett. | pmid:25661734 |
| Liao YF et al. | Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. | 2015 | Mol Med Rep | pmid:25650742 |
| Mori N et al. | Activation of PKC-δ in HTLV-1-infected T cells. | 2015 | Int. J. Oncol. | pmid:25625567 |
| Cordeiro B et al. | Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. | 2015 | Ann. Thorac. Surg. | pmid:25527424 |
| Lin CC et al. | Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. | 2015 | Enzyme Microb. Technol. | pmid:25435499 |
| Dang DK et al. | Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. | 2015 | Clin. Exp. Pharmacol. Physiol. | pmid:25400014 |
| Tiwari RL et al. | PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes. | 2014 | J. Lipid Res. | pmid:24792928 |
| Szilagyi K et al. | PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages. | 2014 | Cardiovasc. Res. | pmid:25253077 |
| Yang JH et al. | Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24211276 |
| Gangwar M et al. | Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. | 2014 | ScientificWorldJournal | pmid:25525615 |
| Hasima N and Ozpolat B | Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. | 2014 | Cell Death Dis | pmid:25375374 |
| Song P et al. | PKCδ promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc. | 2014 | Oxid Med Cell Longev | pmid:25371776 |
| Chen Q et al. | PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. | 2014 | PLoS ONE | pmid:25350560 |
| Ashour AA et al. | Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. | 2014 | J. Cell. Mol. Med. | pmid:25215932 |
| Naskar S et al. | Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy. | 2014 | PLoS ONE | pmid:25116170 |
| Nobe K et al. | Two types of overcontraction are involved in intrarenal artery dysfunction in type II diabetic mouse. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25085043 |
| Lu W et al. | Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells. | 2014 | Cell. Signal. | pmid:24607787 |
| Ashour AA et al. | Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. | 2014 | Apoptosis | pmid:24193916 |
| Pandur S et al. | Combined incubation of colon carcinoma cells with phorbol ester and mitochondrial uncoupling agents results in synergic elevated reactive oxygen species levels and increased γ-glutamyltransferase expression. | 2014 | Mol. Cell. Biochem. | pmid:24281857 |
| Hagelkruys A et al. | A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. | 2014 | Development | pmid:24449838 |
| Fenyvesi F et al. | Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis. | 2014 | PLoS ONE | pmid:24416301 |
| Kumar D et al. | Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. | 2014 | Cancer Lett. | pmid:24125861 |
| Liu ZC et al. | Translocation of protein kinase C δ contributes to the moderately high glucose-, but not hypoxia-induced proliferation in primary cultured human retinal endothelial cells. | 2014 | Mol Med Rep | pmid:24626810 |
| Huang M et al. | Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. | 2014 | Cancer Lett. | pmid:25050737 |
| Freebern WJ et al. | Methods: implementation of in vitro and ex vivo phagocytosis and respiratory burst function assessments in safety testing. | 2013 Jan-Mar | J Immunotoxicol | pmid:23173903 |
| Sheean RK et al. | Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. | 2013 | Neuroscience | pmid:24095695 |
| Gonzalez-Garcia JR et al. | The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. | 2013 | J. Cell. Physiol. | pmid:22566126 |
| Zhu S et al. | PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24289563 |
| Yu HS et al. | Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. | 2013 | Prostate | pmid:22653778 |
| Cristóvão AC et al. | PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23827392 |
| Chan TK et al. | Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. | 2013 | Phytomedicine | pmid:23632085 |
| Leppänen T et al. | Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. | 2013 | PLoS ONE | pmid:23326354 |
| Song BW et al. | Protein kinase C activation stimulates mesenchymal stem cell adhesion through activation of focal adhesion kinase. | 2013 | Cell Transplant | pmid:23006313 |
| Wang J et al. | PTPα-mediated Src activation by EGF in human breast cancer cells. | 2013 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:23532252 |
| Meehan AC et al. | Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. | 2013 | PLoS ONE | pmid:23555904 |
| Lee SJ et al. | PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. | 2013 | PLoS ONE | pmid:23441159 |
| Yun N and Lee SM | Activation of protein kinase C delta reduces hepatocellular damage in ischemic preconditioned rat liver. | 2013 | J. Surg. Res. | pmid:23932656 |
| Khor EC et al. | Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. | 2013 | PLoS ONE | pmid:23951014 |
| Goldklang MP et al. | Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. | 2013 | FASEB J. | pmid:23995289 |
| Kumar D et al. | Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms. | 2013 | Mol. Cancer | pmid:24359639 |
| Jain SK et al. | Semisynthesis of mallotus B from rottlerin: evaluation of cytotoxicity and apoptosis-inducing activity. | 2013 | J. Nat. Prod. | pmid:24041234 |
| Mendonça MC et al. | Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. | 2012 Sep-Oct | Vascul. Pharmacol. | pmid:22583821 |
| Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
| Maioli E et al. | Rottlerin and cancer: novel evidence and mechanisms. | 2012 | ScientificWorldJournal | pmid:22272173 |
| Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
| Furuya T et al. | Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor. | 2012 | Curr. Eye Res. | pmid:22335803 |