rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Matschke V et al. The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels. 2016 Cell. Physiol. Biochem. pmid:27997884
Mischitelli M et al. Stimulation of Suicidal Erythrocyte Death by Rottlerin. 2016 Cell. Physiol. Biochem. pmid:27889758
Xie L et al. Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. 2016 PLoS ONE pmid:27442243
Atef ME and Anand-Srivastava MB Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. 2016 PLoS ONE pmid:27379421
Satoh K et al. Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini. 2016 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26744470
Chen RC et al. Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway. 2015 Food Funct pmid:25773745
Kawabata H et al. A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. 2015 Exp. Hematol. pmid:25633564
Hong KK et al. The Mosaic of Rottlerin. 2015 J. Org. Chem. pmid:26426936
Xu H et al. Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. 2015 Pharmacology pmid:26021525
Torricelli C et al. Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. 2015 Cancer Lett. pmid:25661734
Liao YF et al. Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion. 2015 Mol Med Rep pmid:25650742
Mori N et al. Activation of PKC-δ in HTLV-1-infected T cells. 2015 Int. J. Oncol. pmid:25625567
Cordeiro B et al. Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation. 2015 Ann. Thorac. Surg. pmid:25527424
Lin CC et al. Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. 2015 Enzyme Microb. Technol. pmid:25435499
Dang DK et al. Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. 2015 Clin. Exp. Pharmacol. Physiol. pmid:25400014
Tuorkey MJ Cancer Therapy with Phytochemicals: Present and Future Perspectives. 2015 Biomed. Environ. Sci. pmid:26695359
Huang SP et al. Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. 2015 Dis Model Mech pmid:26092127
Cordeiro B et al. BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion. 2015 Am. J. Physiol. Heart Circ. Physiol. pmid:26071546
Faria CC et al. Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. 2015 Oncotarget pmid:26061748
Sheats MK et al. In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. 2015 Inflammation pmid:25515270