| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with rottlerin?
Related references are published most in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Appl. Environ. Microbiol. (1)
- Others (10)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bae JH et al. | Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction. | 2012 | Cancer Sci. | pmid:21951556 |
| Guo D et al. | Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. | 2012 | Mol. Cell. Neurosci. | pmid:22521536 |
| Contreras X et al. | Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. | 2012 | Retrovirology | pmid:22554282 |
| Lee YS and Choi EM | Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3-E1 cells. | 2012 | J. Oral Pathol. Med. | pmid:21958211 |
| Brutman-Barazani T et al. | Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. | 2012 | J. Cell. Biochem. | pmid:22271577 |
| Maioli E et al. | Rottlerin and cancer: novel evidence and mechanisms. | 2012 | ScientificWorldJournal | pmid:22272173 |
| Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
| Furuya T et al. | Role of retinal glial cell glutamate transporters in retinal ganglion cell survival following stimulation of NMDA receptor. | 2012 | Curr. Eye Res. | pmid:22335803 |
| Deng B et al. | Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits. | 2012 | J. Vasc. Res. | pmid:22261918 |
| Chang WT et al. | Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells. | 2012 | Anticancer Res. | pmid:22993309 |
| Lei L et al. | Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). | 2012 | PLoS ONE | pmid:22970301 |
| Ku CS et al. | Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. | 2012 | J. Nutr. Biochem. | pmid:22209005 |
| Tcatchoff L et al. | Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. | 2012 | PLoS ONE | pmid:22792315 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Xing AP et al. | Cigarette smoke extract stimulates rat pulmonary artery smooth muscle cell proliferation via PKC-PDGFB signaling. | 2012 | J. Biomed. Biotechnol. | pmid:22754279 |
| Maioli E et al. | Rottlerin and curcumin: a comparative analysis. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22758638 |
| Narumi K et al. | Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: the role of protein kinase C (PKC). | 2012 | Int J Pharm | pmid:22426323 |
| Li Z et al. | Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells. | 2012 | Oncol. Rep. | pmid:22427054 |
| Shin EJ et al. | Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. | 2012 | Behav. Brain Res. | pmid:22512859 |
| Latorre E et al. | Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. | 2012 | Mol. Cancer | pmid:22436134 |
| Haines RJ et al. | Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. | 2012 | J. Biol. Chem. | pmid:22696221 |
| Huang CY et al. | Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. | 2012 | Arthritis Rheum. | pmid:22674286 |
| Alapati K et al. | uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. | 2012 | Int. J. Oncol. | pmid:22641287 |
| Kolasa E et al. | Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. | 2012 | Toxicol In Vitro | pmid:22643241 |
| Yun N et al. | Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning. | 2012 | J Physiol Sci | pmid:22359070 |
| Chen RX et al. | Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes. | 2012 | Cell. Physiol. Biochem. | pmid:22832358 |
| Okuwa H et al. | Sphingosine suppresses mesothelioma cell proliferation by inhibiting PKC-δ and inducing cell cycle arrest at the G(0)/G(1) phase. | 2012 | Cell. Physiol. Biochem. | pmid:23221613 |
| Kim YS et al. | Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells. | 2012 | PLoS ONE | pmid:23226259 |
| Chen BR et al. | Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. | 2012 | PLoS ONE | pmid:23155470 |
| Lin YM et al. | The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. | 2012 | PLoS ONE | pmid:23185512 |
| Barrias ES et al. | Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cell. | 2012 | Microbes Infect. | pmid:23010292 |
| Hsu JL et al. | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. | 2012 | Biochem. Pharmacol. | pmid:22490701 |
| Lin W et al. | Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation. | 2012 | Eur J Med Chem | pmid:22093759 |
| Jäntti MH et al. | OX1 orexin/hypocretin receptor activation of phospholipase D. | 2012 | Br. J. Pharmacol. | pmid:21718304 |
| Schug TT | Targeting transcription through inhibition of TBP. | 2011 Jan-Feb | Oncotarget | pmid:21378415 |
| Ko NY et al. | Interleukin-32α production is regulated by MyD88-dependent and independent pathways in IL-1β-stimulated human alveolar epithelial cells. | 2011 Jan-Feb | Immunobiology | pmid:20430472 |
| Kim H et al. | EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells. | 2011 | J. Immunother. | pmid:21499124 |
| Chung YW et al. | Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. | 2011 | J. Biol. Chem. | pmid:21705328 |
| Li S et al. | Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes. | 2011 | Mol. Cell. Neurosci. | pmid:21708260 |
| Malla N et al. | Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway. | 2011 | PLoS ONE | pmid:21673806 |
| Park EJ and Kwon TK | Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. | 2011 | Exp. Mol. Med. | pmid:21971413 |
| Chen Z et al. | Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. | 2011 | Endocr. Relat. Cancer | pmid:21990324 |
| Prast-Nielsen S et al. | Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. | 2011 | Free Radic. Biol. Med. | pmid:21262347 |
| da Silva Cunha KC et al. | A phospholipase Aâ‚‚ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro. | 2011 | Toxicon | pmid:21223976 |
| Lee SE et al. | Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells. | 2011 | Toxicol. Lett. | pmid:21238556 |
| Yang QE et al. | Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. | 2011 | Biol. Reprod. | pmid:21191110 |
| Tsai RK et al. | PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. | 2011 | Mol. Vis. | pmid:21738386 |
| Lawal AO and Ellis EM | Nrf2-mediated adaptive response to cadmium-induced toxicity involves protein kinase C delta in human 1321N1 astrocytoma cells. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787730 |
| Clements RT et al. | Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts. | 2011 | Circulation | pmid:21911819 |
| Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |