Soltoff SP |
Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. |
2007 |
Trends Pharmacol. Sci. |
pmid:17692392
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Thomas R and Kim MH |
Targeting the hypoxia inducible factor pathway with mitochondrial uncouplers. |
2007 |
Mol. Cell. Biochem. |
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Lu R et al. |
Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. |
2007 |
J. Biol. Chem. |
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Park YS et al. |
Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
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Bull ND et al. |
Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. |
2007 |
Curr. Eye Res. |
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Kamiya K et al. |
Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration. |
2007 |
J. Surg. Res. |
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Zhu S et al. |
Effect of PKC isozyme inhibition on forskolin-induced activation of BKCa channels in rat pulmonary arterial smooth muscle. |
2006 Mar-Apr |
Lung |
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[Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell]. |
2006 |
Zhonghua Yi Xue Za Zhi |
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Hsu PC et al. |
Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. |
2006 |
Apoptosis |
pmid:16520895
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Suguro T et al. |
Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. |
2006 |
Atherosclerosis |
pmid:16157345
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Fronhofer V et al. |
Role of PKC isoforms in the Fc(gamma)R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. |
2006 |
J. Leukoc. Biol. |
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Nakajima T et al. |
Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. |
2006 |
Mutat. Res. |
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Hanrott K et al. |
6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cdelta. |
2006 |
J. Biol. Chem. |
pmid:16361258
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Tapia JA et al. |
Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. |
2006 |
Biochim. Biophys. Acta |
pmid:16364465
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Collins NT et al. |
Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. |
2006 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:16269664
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Andreeva AY et al. |
Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. |
2006 |
Int. J. Biochem. Cell Biol. |
pmid:16257565
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Hughes PJ et al. |
Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. |
2006 |
J. Cell. Biochem. |
pmid:16178010
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Hsieh HL et al. |
BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes. |
2006 |
J. Cell. Physiol. |
pmid:15991247
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Jane EP et al. |
Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16959960
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Zeng H et al. |
Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16928897
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Pula G et al. |
PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. |
2006 |
Blood |
pmid:16940418
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Shukla A et al. |
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. |
2006 |
FASEB J. |
pmid:16571779
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Rushworth SA et al. |
Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16460683
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Ringshausen I et al. |
Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL. |
2006 |
Leukemia |
pmid:16437144
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Zatta AJ et al. |
Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling. |
2006 |
Cardiovasc. Res. |
pmid:16443207
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Zhu M et al. |
Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. |
2006 |
Cancer Lett. |
pmid:16455194
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Ikewaki N et al. |
Regulation of CD93 cell surface expression by protein kinase C isoenzymes. |
2006 |
Microbiol. Immunol. |
pmid:16490927
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SedmÃková M et al. |
Effect of protein kinase C inhibitors on porcine oocyte activation. |
2006 |
J. Exp. Zoolog. Part A Comp. Exp. Biol. |
pmid:16493646
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Waki K et al. |
Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils. |
2006 |
Free Radic. Res. |
pmid:16517500
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Takahashi A et al. |
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. |
2006 |
Nat. Cell Biol. |
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Pakozdi A et al. |
Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. |
2006 |
Arthritis Res. Ther. |
pmid:16872482
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Zhou Y et al. |
Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation. |
2006 |
Int. J. Biochem. Cell Biol. |
pmid:16950644
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Sarkis PT et al. |
STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-alpha. |
2006 |
J. Immunol. |
pmid:16982890
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Shoichet BK |
Interpreting steep dose-response curves in early inhibitor discovery. |
2006 |
J. Med. Chem. |
pmid:17149857
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Cronshaw DG et al. |
Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22. |
2006 |
J. Leukoc. Biol. |
pmid:16614259
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Lee CF et al. |
Involvement of protein kinase C delta in the alteration of mitochondrial mass in human cells under oxidative stress. |
2006 |
Free Radic. Biol. Med. |
pmid:16785027
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Zou Y et al. |
Contact inhibition causes strong downregulation of expression of MICA in human fibroblasts and decreased NK cell killing. |
2006 |
Hum. Immunol. |
pmid:16698440
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Nobe K et al. |
High-glucose-altered endothelial cell function involves both disruption of cell-to-cell connection and enhancement of force development. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16699065
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Im YJ et al. |
Multiple actions of lysophosphatidylcholine in human Jurkat T cells. |
2006 |
Acta Pharmacol. Sin. |
pmid:16723088
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Ahn BK et al. |
Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium. |
2006 |
J. Invest. Dermatol. |
pmid:16575394
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Chen ZF et al. |
[The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. |
2006 |
Zhonghua Zhong Liu Za Zhi |
pmid:17236547
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Ceni E et al. |
Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells. |
2006 |
Gastroenterology |
pmid:17030193
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Shoenfelt JL and Fenton MJ |
TLR2- and TLR4-dependent activation of STAT1 serine phosphorylation in murine macrophages is protein kinase C-delta-independent. |
2006 |
J. Endotoxin Res. |
pmid:16953975
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Wung BS et al. |
Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. |
2006 |
Pharmacol. Res. |
pmid:16243536
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Jang IS et al. |
Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process. |
2006 |
Mech. Ageing Dev. |
pmid:16516270
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Barman SA and Marrero MB |
Mechanism of endothelin-1 activation of MAP kinases in neonatal pulmonary vascular smooth muscle. |
2005 Nov-Dec |
Lung |
pmid:16465602
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Obara K et al. |
Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model. |
2005 Jan-Feb |
J. Vasc. Res. |
pmid:15637442
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Nabha SM et al. |
Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells. |
2005 |
Oncogene |
pmid:15735693
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Nitti M et al. |
Central role of PKCdelta in glycoxidation-dependent apoptosis of human neurons. |
2005 |
Free Radic. Biol. Med. |
pmid:15749380
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Hurbin A et al. |
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. |
2005 |
J. Biol. Chem. |
pmid:15767261
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Obreja O et al. |
Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. |
2005 |
Brain |
pmid:15817518
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Wiedłocha A et al. |
Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1. |
2005 |
Mol. Biol. Cell |
pmid:15574884
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Amos S et al. |
Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. |
2005 |
J. Biol. Chem. |
pmid:15618223
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Sarkar K et al. |
Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells. |
2005 |
Immunology |
pmid:16313365
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Zhang X et al. |
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. |
2005 |
EMBO J. |
pmid:16319926
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Payvandi F et al. |
Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. |
2005 |
J. Interferon Cytokine Res. |
pmid:16241859
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Kim IS et al. |
Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells. |
2005 |
FEBS Lett. |
pmid:16226254
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Zhao KW et al. |
Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. |
2005 |
J. Biol. Chem. |
pmid:16260419
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Oh JI et al. |
Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. |
2005 |
Cancer Lett. |
pmid:16297709
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Woo CH et al. |
VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:15489375
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Lewis AE et al. |
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. |
2005 |
Cell. Signal. |
pmid:15494216
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Zhang J et al. |
PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. |
2005 |
J. Cell. Biochem. |
pmid:16114000
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Brown JM et al. |
Effects of rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice. |
2005 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:16040631
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Kishida O et al. |
Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. |
2005 |
Cancer Chemother. Pharmacol. |
pmid:15723263
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Rao PE et al. |
Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}. |
2005 |
J. Immunol. |
pmid:15661903
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Ducroc R et al. |
Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose cotransporter 1. |
2005 |
Diabetes |
pmid:15677491
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Ahmed S et al. |
Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. |
2005 |
FEBS J. |
pmid:15691325
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Fan CY et al. |
PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. |
2005 |
Biochem. J. |
pmid:15913451
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Panaretakis T et al. |
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. |
2005 |
Mol. Biol. Cell |
pmid:15917298
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Tse SM et al. |
Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. |
2005 |
J. Biol. Chem. |
pmid:15863503
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Miguel BG et al. |
Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. |
2005 |
Biochim. Biophys. Acta |
pmid:15843035
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Liao YF et al. |
The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. |
2005 |
Life Sci. |
pmid:15922001
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Roose JP et al. |
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. |
2005 |
Mol. Cell. Biol. |
pmid:15899849
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Zakharov SI et al. |
Activation of the BK (SLO1) potassium channel by mallotoxin. |
2005 |
J. Biol. Chem. |
pmid:15998639
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Avila GE et al. |
Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. |
2005 |
J. Pharmacol. Exp. Ther. |
pmid:15976015
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Chen S et al. |
Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. |
2005 |
J. Steroid Biochem. Mol. Biol. |
pmid:15955695
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Tepperman BL et al. |
Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells. |
2005 |
Eur. J. Pharmacol. |
pmid:16005455
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Yamaguchi K et al. |
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. |
2005 |
Cancer Chemother. Pharmacol. |
pmid:16012865
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Skaletz-Rorowski A et al. |
PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells. |
2005 |
Cardiovasc. Res. |
pmid:15949478
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Kim DC et al. |
Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:16182255
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Styles NA et al. |
Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C. |
2005 |
Neurochem. Int. |
pmid:16183168
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Kim EH et al. |
Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP. |
2005 |
Oncogene |
pmid:15531913
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Cummings R et al. |
Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. |
2004 |
J. Biol. Chem. |
pmid:15280372
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Contreras X et al. |
IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes. |
2004 |
Microbes Infect. |
pmid:15488737
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Kohro S et al. |
Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes. |
2004 |
Anesth. Analg. |
pmid:15502023
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Bey EA et al. |
Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. |
2004 |
J. Immunol. |
pmid:15494525
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Tan M et al. |
Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15499041
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Welters HJ et al. |
Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. |
2004 |
J. Mol. Endocrinol. |
pmid:14766004
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Durrant D et al. |
The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15358112
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You HJ et al. |
A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. |
2004 |
Biochem. Biophys. Res. Commun. |
pmid:15358156
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Deutsch E et al. |
Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. |
2004 |
J. Virol. |
pmid:15331751
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Wheaton K and Riabowol K |
Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factor. |
2004 |
Mol. Cell. Biol. |
pmid:15282327
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Schreckenberg R et al. |
Inhibition of Ca2+-dependent PKC isoforms unmasks ERK-dependent hypertrophic growth evoked by phenylephrine in adult ventricular cardiomyocytes. |
2004 |
Cardiovasc. Res. |
pmid:15276481
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Chintalgattu V and Katwa LC |
Role of protein kinase Cdelta in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction. |
2004 |
J. Pharmacol. Exp. Ther. |
pmid:15240825
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Li C et al. |
Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. |
2004 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:15217780
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Shin SY et al. |
Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. |
2004 |
J. Mol. Biol. |
pmid:15223313
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Mimura Y et al. |
Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. |
2004 |
J. Invest. Dermatol. |
pmid:15175028
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Hassan S et al. |
Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. |
2004 |
Regul. Pept. |
pmid:15177934
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Kang HS et al. |
Receptor activator of nuclear factor-kappaB is induced by a rottlerin-sensitive and p38 MAP kinase-dependent pathway during monocyte differentiation. |
2004 |
Mol. Cells |
pmid:15232218
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Lladó A et al. |
Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes. |
2004 |
Mol. Biol. Cell |
pmid:15342779
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