rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with rottlerin

Download all related citations
Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Gore-Hyer E et al. Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. 2003 Arthritis Rheum. pmid:12632435
Huang CY et al. Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. 2012 Arthritis Rheum. pmid:22674286
Zhu S et al. PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. 2013 Asian Pac. J. Cancer Prev. pmid:24289563
Mooi LY et al. Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. 2012 Asian Pac. J. Cancer Prev. pmid:22799301
Suguro T et al. Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. 2006 Atherosclerosis pmid:16157345
Song KS et al. Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. 2008 Autophagy pmid:18424913
Ozpolat B et al. PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. 2007 Sep-Oct Autophagy pmid:17507797
Xu SZ Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17927688
Fryer RM et al. PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. 2002 Basic Res. Cardiol. pmid:11998977
Shin EJ et al. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. 2012 Behav. Brain Res. pmid:22512859
Takahashi T and Shibuya M The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. 2001 Biochem. Biophys. Res. Commun. pmid:11162532
Grandvaux N et al. Oxidant-dependent phosphorylation of p40phox in B lymphocytes. 2001 Biochem. Biophys. Res. Commun. pmid:11573965
Leung CH et al. PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. 2001 Biochem. Biophys. Res. Commun. pmid:11444839
Dietrich C et al. Rottlerin induces a transformed phenotype in human keratinocytes. 2001 Biochem. Biophys. Res. Commun. pmid:11401499
Fang Q et al. PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. 2008 Biochem. Biophys. Res. Commun. pmid:18342628
Huwiler A et al. Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. 2003 Biochem. Biophys. Res. Commun. pmid:12732207
Kim DC et al. Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. 2005 Biochem. Biophys. Res. Commun. pmid:16182255
Kojima K et al. Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues. 2008 Biochem. Biophys. Res. Commun. pmid:18789895
Cristóvão AC et al. PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. 2013 Biochem. Biophys. Res. Commun. pmid:23827392
Gschwendt M et al. Rottlerin, a novel protein kinase inhibitor. 1994 Biochem. Biophys. Res. Commun. pmid:8123051