| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Park SK et al. | Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. | 2009 | Carcinogenesis | pmid:19420016 |
| Bae JH et al. | Susceptibility to natural killer cell-mediated lysis of colon cancer cells is enhanced by treatment with epidermal growth factor receptor inhibitors through UL16-binding protein-1 induction. | 2012 | Cancer Sci. | pmid:21951556 |
| Basu A et al. | Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway. | 2008 | Cancer Res. | pmid:18413747 |
| Tillman DM et al. | Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. | 2003 | Cancer Res. | pmid:12941843 |
| Clark AS et al. | Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. | 2003 | Cancer Res. | pmid:12591726 |
| Kurosu T et al. | Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. | 2009 | Cancer Res. | pmid:19366808 |
| Shanmugam M et al. | A role for protein kinase C delta in the differential sensitivity of MCF-7 and MDA-MB 231 human breast cancer cells to phorbol ester-induced growth arrest and p21(WAFI/CIP1) induction. | 2001 | Cancer Lett. | pmid:11595128 |
| Daveri E et al. | Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing. | 2016 | Cancer Lett. | pmid:27343979 |
| Torricelli C et al. | Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin. | 2015 | Cancer Lett. | pmid:25661734 |
| Oh JI et al. | Caspase-3-dependent protein kinase C delta activity is required for the progression of Ginsenoside-Rh2-induced apoptosis in SK-HEP-1 cells. | 2005 | Cancer Lett. | pmid:16297709 |
| Zhu M et al. | Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes. | 2006 | Cancer Lett. | pmid:16455194 |
| Kumar D et al. | Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. | 2014 | Cancer Lett. | pmid:24125861 |
| Huang M et al. | Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. | 2014 | Cancer Lett. | pmid:25050737 |
| Kishida O et al. | Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. | 2005 | Cancer Chemother. Pharmacol. | pmid:15723263 |
| Yamaguchi K et al. | Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. | 2005 | Cancer Chemother. Pharmacol. | pmid:16012865 |
| Sun S et al. | Protein kinase C δ-dependent regulation of Ubiquitin-proteasome system function in breast cancer. | 2017 | Cancer Biomark | pmid:29036789 |
| Lishmanov YB et al. | Involvement of Protein Kinase C-δ in the Realization of Cardioprotective Effect of Ischemic Postconditioning. | 2016 | Bull. Exp. Biol. Med. | pmid:27496038 |
| Miller RL et al. | Cytotoxicity of paraquat in microglial cells: Involvement of PKCdelta- and ERK1/2-dependent NADPH oxidase. | 2007 | Brain Res. | pmid:17662968 |
| Obreja O et al. | Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. | 2005 | Brain | pmid:15817518 |
| Cho JY et al. | Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. | 2003 | Br. J. Pharmacol. | pmid:12970105 |
| Jäntti MH et al. | OX1 orexin/hypocretin receptor activation of phospholipase D. | 2012 | Br. J. Pharmacol. | pmid:21718304 |
| Ni H et al. | Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis. | 2003 | Br. J. Haematol. | pmid:12786795 |
| Yamaguchi R et al. | Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. | 2016 | Blood Cells Mol. Dis. | pmid:26852662 |
| Pula G et al. | PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation. | 2006 | Blood | pmid:16940418 |
| Shirasugi I et al. | Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. | 2010 | Biosci. Biotechnol. Biochem. | pmid:21071833 |
| Itoh T et al. | Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. | 2008 | Bioorg. Med. Chem. | pmid:18328716 |
| Rohilla A et al. | Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts. | 2010 | Biomed. Pharmacother. | pmid:19914792 |
| Rohilla A and Balakumar P | The infarct size-limiting effect of ischemic postconditioning (IPOC) is suppressed in isolated hyperhomocysteinemic (Hhcy) rat hearts: the reasonable role of PKC-delta. | 2009 | Biomed. Pharmacother. | pmid:19914793 |
| Tuorkey MJ | Cancer Therapy with Phytochemicals: Present and Future Perspectives. | 2015 | Biomed. Environ. Sci. | pmid:26695359 |
| Budnik LT and Mukhopadhyay AK | Lysophosphatidic acid-induced nuclear localization of protein kinase C delta in bovine theca cells stimulated with luteinizing hormone. | 2002 | Biol. Reprod. | pmid:12193405 |
| Yang QE et al. | Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. | 2011 | Biol. Reprod. | pmid:21191110 |
| Kaur K et al. | Possible mechanism of rottlerin induced modulation of ischemia reperfusion injury in isolated rat hearts. | 2008 | Biol. Pharm. Bull. | pmid:18758070 |
| Choi YA et al. | Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells. | 2009 | Biochimie | pmid:19306958 |
| Park EJ et al. | Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. | 2010 | Biochimie | pmid:19833168 |
| Matta C et al. | PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures. | 2011 | Biochimie | pmid:20850497 |
| Tapia JA et al. | Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism. | 2006 | Biochim. Biophys. Acta | pmid:16364465 |
| Miguel BG et al. | Regulation of cadmium-induced apoptosis by PKCdelta in U937 human promonocytic cells. | 2005 | Biochim. Biophys. Acta | pmid:15843035 |
| Tomkova S et al. | In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells. | 2018 | Biochim. Biophys. Acta | pmid:29410069 |
| Cho SI et al. | Novel compounds, '1,3-selenazine derivatives' as specific inhibitors of eukaryotic elongation factor-2 kinase. | 2000 | Biochim. Biophys. Acta | pmid:10913818 |
| Sugawara T et al. | PKCδ and ε regulate the morphological integrity of the ER-Golgi intermediate compartment (ERGIC) but not the anterograde and retrograde transports via the Golgi apparatus. | 2012 | Biochim. Biophys. Acta | pmid:22326427 |
| Ahn BH et al. | Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. | 2007 | Biochim. Biophys. Acta | pmid:17640750 |
| Liu CY et al. | Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. | 2009 | Biochim. Biophys. Acta | pmid:19477272 |
| Fordjour AK and Harrington EO | PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. | 2009 | Biochim. Biophys. Acta | pmid:19632305 |
| Sarkar N et al. | Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme. | 2011 | Biochim. Biophys. Acta | pmid:21723915 |
| Chao H et al. | Activation of bradykinin B2 receptor induced the inflammatory responses of cytosolic phospholipase A after the early traumatic brain injury. | 2018 | Biochim Biophys Acta Mol Basis Dis | pmid:29894755 |
| Palmer TM and Stiles GL | Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. | 1999 | Biochemistry | pmid:10555965 |
| Basu A and Akkaraju GR | Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. | 1999 | Biochemistry | pmid:10194341 |
| Springael C et al. | Rottlerin inhibits human T cell responses. | 2007 | Biochem. Pharmacol. | pmid:17141738 |
| Bazuine M et al. | Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. | 2004 | Biochem. Pharmacol. | pmid:15183122 |
| Domenicotti C et al. | A novel role of protein kinase C-delta in cell signaling triggered by glutathione depletion. | 2003 | Biochem. Pharmacol. | pmid:14555230 |
| Singh BN et al. | Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. | 2012 | Biochem. Pharmacol. | pmid:22902833 |
| Hsu JL et al. | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway. | 2012 | Biochem. Pharmacol. | pmid:22490701 |
| Thabard W et al. | Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. | 2001 | Biochem. J. | pmid:11485567 |
| Bain J et al. | The selectivity of protein kinase inhibitors: a further update. | 2007 | Biochem. J. | pmid:17850214 |
| Ghelli A et al. | Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. | 2002 | Biochem. J. | pmid:12014986 |
| Wang L et al. | Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. | 2003 | Biochem. J. | pmid:12720544 |
| Fan CY et al. | PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy. | 2005 | Biochem. J. | pmid:15913451 |
| Wert MM and Palfrey HC | Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. | 2000 | Biochem. J. | pmid:11062070 |
| Davies SP et al. | Specificity and mechanism of action of some commonly used protein kinase inhibitors. | 2000 | Biochem. J. | pmid:10998351 |
| Takahashi T and Shibuya M | The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162532 |
| Grandvaux N et al. | Oxidant-dependent phosphorylation of p40phox in B lymphocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573965 |
| Lange Y et al. | Effect of protein kinase C on endoplasmic reticulum cholesterol. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779197 |
| Wang Z et al. | Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29203243 |
| Pandey S et al. | Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27498028 |
| Leung CH et al. | PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11444839 |
| Dietrich C et al. | Rottlerin induces a transformed phenotype in human keratinocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11401499 |
| Fang Q et al. | PKCdelta mediates thrombin-augmented fibroblast-mediated collagen gel contraction. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18342628 |
| Liu JF et al. | FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054499 |
| Huwiler A et al. | Inflammatory cytokines upregulate nephrin expression in human embryonic kidney epithelial cells and podocytes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12732207 |
| Rushworth SA et al. | Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16460683 |
| Durrant D et al. | The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358112 |
| You HJ et al. | A pathway involving protein kinase Cdelta up-regulates cytosolic phospholipase A(2)alpha in airway epithelium. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15358156 |
| Kim DC et al. | Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16182255 |
| Kojima K et al. | Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18789895 |
| Cristóvão AC et al. | PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23827392 |
| Chintalgattu V and Katwa LC | Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19540196 |
| Gschwendt M et al. | Rottlerin, a novel protein kinase inhibitor. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8123051 |
| Shin EJ et al. | Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. | 2012 | Behav. Brain Res. | pmid:22512859 |
| Fryer RM et al. | PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats. | 2002 | Basic Res. Cardiol. | pmid:11998977 |
| Xu SZ | Rottlerin induces calcium influx and protein degradation in cultured lenses independent of effects on protein kinase C delta. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17927688 |
| Song KS et al. | Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. | 2008 | Autophagy | pmid:18424913 |
| Ozpolat B et al. | PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. | 2007 Sep-Oct | Autophagy | pmid:17507797 |
| Suguro T et al. | Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. | 2006 | Atherosclerosis | pmid:16157345 |
| Zhu S et al. | PKC?-dependent activation of the ubiquitin proteasome system is responsible for high glucose-induced human breast cancer MCF-7 cell proliferation, migration and invasion. | 2013 | Asian Pac. J. Cancer Prev. | pmid:24289563 |
| Mooi LY et al. | Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22799301 |
| Gore-Hyer E et al. | Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. | 2003 | Arthritis Rheum. | pmid:12632435 |
| Tang CH et al. | The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. | 2010 | Arthritis Rheum. | pmid:20862675 |
| Huang CY et al. | Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. | 2012 | Arthritis Rheum. | pmid:22674286 |
| Pakozdi A et al. | Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. | 2006 | Arthritis Res. Ther. | pmid:16872482 |
| Collins NT et al. | Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16269664 |
| Tan M et al. | Angiotensin II-induced protein kinase D activation is regulated by protein kinase Cdelta and mediated via the angiotensin II type 1 receptor in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15499041 |
| Park YS et al. | Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17363696 |
| Shin EJ et al. | Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism. | 2016 | Arch. Toxicol. | pmid:25895139 |
| Miskolci V et al. | Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. | 2003 | Arch. Biochem. Biophys. | pmid:12921778 |
| Shivshankar P et al. | Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells. | 2008 | Appl. Environ. Microbiol. | pmid:18083882 |
| Hsu PC et al. | Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. | 2006 | Apoptosis | pmid:16520895 |
| Longpre JM and Loo G | Protection of human colon epithelial cells against deoxycholate by rottlerin. | 2008 | Apoptosis | pmid:18661240 |
| Lim JH et al. | Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells. | 2008 | Apoptosis | pmid:18807195 |
| Ashour AA et al. | Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. | 2014 | Apoptosis | pmid:24193916 |
| Abdelnabi R et al. | Protein kinases C as potential host targets for the inhibition of chikungunya virus replication. | 2017 | Antiviral Res. | pmid:28039020 |