rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with rottlerin?

rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with rottlerin

MeSH term MeSH ID Detail
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 | Total 39

PubChem Associated disorders and diseases

What pathways are associated with rottlerin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with rottlerin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with rottlerin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with rottlerin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with rottlerin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with rottlerin?

Cancer Model

Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).

Mouse Model

Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).

Xenograft Model

Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with rottlerin

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Per page 10 20 50 100 | Total 547
Authors Title Published Journal PubMed Link
Sheean RK et al. Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin. 2013 Neuroscience pmid:24095695
Gonzalez-Garcia JR et al. The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs. 2013 J. Cell. Physiol. pmid:22566126
Yu HS et al. Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. 2013 Prostate pmid:22653778
Cristóvão AC et al. PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. 2013 Biochem. Biophys. Res. Commun. pmid:23827392
Chan TK et al. Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models. 2013 Phytomedicine pmid:23632085
Leppänen T et al. Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. 2013 PLoS ONE pmid:23326354
Song BW et al. Protein kinase C activation stimulates mesenchymal stem cell adhesion through activation of focal adhesion kinase. 2013 Cell Transplant pmid:23006313
Wang J et al. PTPα-mediated Src activation by EGF in human breast cancer cells. 2013 Acta Biochim. Biophys. Sin. (Shanghai) pmid:23532252
Meehan AC et al. Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. 2013 PLoS ONE pmid:23555904
Lee SJ et al. PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. 2013 PLoS ONE pmid:23441159
Yun N and Lee SM Activation of protein kinase C delta reduces hepatocellular damage in ischemic preconditioned rat liver. 2013 J. Surg. Res. pmid:23932656
Khor EC et al. Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. 2013 PLoS ONE pmid:23951014
Goldklang MP et al. Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. 2013 FASEB J. pmid:23995289
Kumar D et al. Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms. 2013 Mol. Cancer pmid:24359639
Jain SK et al. Semisynthesis of mallotus B from rottlerin: evaluation of cytotoxicity and apoptosis-inducing activity. 2013 J. Nat. Prod. pmid:24041234
Mendonça MC et al. Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. 2012 Sep-Oct Vascul. Pharmacol. pmid:22583821
Haines RJ et al. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. 2012 J. Biol. Chem. pmid:22696221
Huang CY et al. Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. 2012 Arthritis Rheum. pmid:22674286
Alapati K et al. uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells. 2012 Int. J. Oncol. pmid:22641287
Kolasa E et al. Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. 2012 Toxicol In Vitro pmid:22643241