| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
rottlerin
Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of rottlerin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with rottlerin?
rottlerin is suspected in Infection, Morphologically altered structure, Ischemia, Pulmonary Edema, Asthma, Cardiovascular Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Biol. Chem. (5)
- Am. J. Physiol. Heart Circ. Physiol. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (19)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with rottlerin
PubChem Associated disorders and diseases
What pathways are associated with rottlerin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with rottlerin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (9)
- J. Pharmacol. Exp. Ther. (4)
- Am. J. Physiol. Lung Cell Mol. Physiol. (3)
- Others (42)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with rottlerin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with rottlerin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with rottlerin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with rottlerin?
Cancer Model
Cancer Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010) and Cancer Model are used in the study 'Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.' (Lu W et al., 2014).
Mouse Model
Mouse Model are used in the study 'Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.' (Zhang D et al., 2007).
Xenograft Model
Xenograft Model are used in the study 'Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.' (Ohno I et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with rottlerin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Min M et al. | Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies. | 2017 | PLoS ONE | pmid:29272319 |
| Filone CM et al. | Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. | 2010 | PLoS ONE | pmid:21124804 |
| Malla N et al. | Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway. | 2011 | PLoS ONE | pmid:21673806 |
| Xie L et al. | Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. | 2016 | PLoS ONE | pmid:27442243 |
| Atef ME and Anand-Srivastava MB | Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats. | 2016 | PLoS ONE | pmid:27379421 |
| Chen Q et al. | PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway. | 2014 | PLoS ONE | pmid:25350560 |
| Lei L et al. | Rottlerin-mediated inhibition of Chlamydia trachomatis growth and uptake of sphingolipids is independent of p38-regulated/activated protein kinase (PRAK). | 2012 | PLoS ONE | pmid:22970301 |
| Tcatchoff L et al. | Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. | 2012 | PLoS ONE | pmid:22792315 |
| Balgi AD et al. | Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. | 2009 | PLoS ONE | pmid:19771169 |
| Kim YS et al. | Glycoxidised LDL induced the upregulation of Axl receptor tyrosine kinase and its ligand in mouse mesangial cells. | 2012 | PLoS ONE | pmid:23226259 |
| Leppänen T et al. | Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1. | 2013 | PLoS ONE | pmid:23326354 |
| Chen BR et al. | Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. | 2012 | PLoS ONE | pmid:23155470 |
| Meehan AC et al. | Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition. | 2013 | PLoS ONE | pmid:23555904 |
| Lee SJ et al. | PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. | 2013 | PLoS ONE | pmid:23441159 |
| Lin YM et al. | The CCL2/CCR2 axis enhances vascular cell adhesion molecule-1 expression in human synovial fibroblasts. | 2012 | PLoS ONE | pmid:23185512 |
| Khor EC et al. | Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption. | 2013 | PLoS ONE | pmid:23951014 |
| Wermuth PJ et al. | Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. | 2011 | PLoS ONE | pmid:22096525 |
| Yu HS et al. | Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway. | 2013 | Prostate | pmid:22653778 |
| Liao TY et al. | Rottlerin impairs the formation and maintenance of psychostimulant-supported memory. | 2016 | Psychopharmacology (Berl.) | pmid:26960698 |
| Carraway RE et al. | Protein kinase C inhibitors alter neurotensin receptor binding and function in prostate cancer PC3 cells. | 2008 | Regul. Pept. | pmid:18313772 |
| Hassan S et al. | Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. | 2004 | Regul. Pept. | pmid:15177934 |
| Yang QE et al. | The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development. | 2016 | Reprod. Fertil. Dev. | pmid:25116760 |
| Contreras X et al. | Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages. | 2012 | Retrovirology | pmid:22554282 |
| Ietta F et al. | Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells. | 2017 | Sci Rep | pmid:28455500 |
| Serrero M et al. | PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production. | 2017 | Sci Rep | pmid:28539656 |
| Guan X et al. | Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. | 2017 | Sci Rep | pmid:28165042 |
| Gangwar M et al. | Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study. | 2014 | ScientificWorldJournal | pmid:25525615 |
| Maioli E et al. | Rottlerin and cancer: novel evidence and mechanisms. | 2012 | ScientificWorldJournal | pmid:22272173 |
| Huda R et al. | Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. | 2004 | Shock | pmid:15167677 |
| Prudnikova TY and Chernoff J | The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. | 2017 | Small GTPases | pmid:27427770 |
| Kolasa E et al. | Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene. | 2012 | Toxicol In Vitro | pmid:22643241 |
| Jang BC | Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. | 2009 | Toxicol In Vitro | pmid:19084589 |
| Kim MH et al. | EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. | 2017 | Toxicol. Appl. Pharmacol. | pmid:27939242 |
| Chen JH et al. | Rottlerin stimulates metallothionein gene expression but inhibits metal transport in Chinese hamster ovary cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11749125 |
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| Kim KM et al. | Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20060010 |
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| Hwang YP et al. | 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression. | 2010 | Toxicol. Lett. | pmid:20599481 |
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| da Silva Cunha KC et al. | A phospholipase Aâ‚‚ isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro. | 2011 | Toxicon | pmid:21223976 |
| Soltoff SP | Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. | 2007 | Trends Pharmacol. Sci. | pmid:17692392 |
| Mendonça MC et al. | Protein kinase C-δ (PKC-δ) and PKC-α mediate Ca(2+)-dependent increases in CNP mRNA in human vascular cells. | 2012 Sep-Oct | Vascul. Pharmacol. | pmid:22583821 |
| Wang H et al. | Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus. | 2018 | Virol. J. | pmid:29793525 |
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| Chen ZF et al. | [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. | 2006 | Zhonghua Zhong Liu Za Zhi | pmid:17236547 |