butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Ovarian Neoplasms D010051 10 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Burns D002056 34 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Ketosis D007662 13 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Corneal Diseases D003316 13 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Hypothyroidism D007037 32 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Occupational Diseases D009784 42 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Thrombosis D013927 49 associated lipids
Peritonitis D010538 38 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Dentin, Secondary D003809 2 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Periodontal Diseases D010510 15 associated lipids
Dental Leakage D003763 5 associated lipids
Lymphoproliferative Disorders D008232 7 associated lipids
Thalassemia D013789 8 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Nervous System Diseases D009422 37 associated lipids
Phenylketonurias D010661 7 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Starvation D013217 47 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Pregnancy in Diabetics D011254 3 associated lipids
Glycogen Storage Disease Type II D006009 2 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pituitary Neoplasms D010911 4 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Periodontitis D010518 22 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Intestinal Neoplasms D007414 2 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Burkitt Lymphoma D002051 15 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Radiation Injuries D011832 14 associated lipids
Adenoma D000236 40 associated lipids
Angina Pectoris D000787 27 associated lipids
Poultry Diseases D011201 21 associated lipids
Hyperkinesis D006948 11 associated lipids
Disease Models, Animal D004195 4 associated lipids
HIV Infections D015658 20 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Hepatoblastoma D018197 10 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Acute Lung Injury D055371 33 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Retinoblastoma D012175 12 associated lipids
Genomic Instability D042822 7 associated lipids
Constipation D003248 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

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Per page 10 20 50 100 | Total 7933
Authors Title Published Journal PubMed Link
Chang G et al. Dietary Sodium Butyrate Supplementation Reduces High-Concentrate Diet Feeding-Induced Apoptosis in Mammary Cells in Dairy Goats. 2018 J. Agric. Food Chem. pmid:29446933
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da Silva JS et al. Nutritive value and fermentation quality of palisadegrass and stylo mixed silages. 2018 Anim. Sci. J. pmid:28905506
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Kurano M et al. Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. 2017 PLoS ONE pmid:28494002
Machado CF et al. Conditional Deletion of in Olfactory Sensory Neurons Leads to Olfactory Impairment. 2017 J. Neurosci. pmid:29118104
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Dou X et al. Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon Toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells. 2017 Oncotarget pmid:28460447
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Niwińska B et al. Review: Exogenous butyrate: implications for the functional development of ruminal epithelium and calf performance. 2017 Animal pmid:28193308
Jaworska J et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. 2017 J Neuroinflammation pmid:28187734
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Owusu BY and Klampfer L Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases. 2017 Methods Mol. Biol. pmid:27761828
Andersen AD et al. Supplementation with Lactobacillus paracasei or Pediococcus pentosaceus does not prevent diarrhoea in neonatal pigs infected with Escherichia coli F18. 2017 Br. J. Nutr. pmid:28720151
Hrgovic I et al. Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. 2017 Exp. Dermatol. pmid:27487811
Yokoyama Y et al. Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap. 2017 Surgery pmid:28684159
Green AL et al. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. 2017 Neuropharmacology pmid:28743636
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Yang S et al. Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. 2017 Chem. Res. Toxicol. pmid:28595002
Zapletal O et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. 2017 Arch. Toxicol. pmid:27830268
Hofmanová J et al. Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities. 2017 Eur J Nutr pmid:26983609
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Anantharaju PG et al. Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). 2017 PLoS ONE pmid:29190639
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Wu Q et al. Tailoring the Oxidative Stress Tolerance of Clostridium tyrobutyricum CCTCC W428 by Introducing Trehalose Biosynthetic Capability. 2017 J. Agric. Food Chem. pmid:28925260
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Chang PJ et al. Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. 2017 J. Virol. pmid:28701396
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Yan H and Ajuwon KM Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. 2017 PLoS ONE pmid:28654658
Batlle-Vilanova P et al. Microbial electrosynthesis of butyrate from carbon dioxide: Production and extraction. 2017 Bioelectrochemistry pmid:28633067
Asquith M et al. Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. 2017 pmid:28622455
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Meenongyai W et al. Effects of forage ensiling and ration fermentation on total mixed ration pH, ruminal fermentation and performance of growing Holstein-Zebu cross steers. 2017 Anim. Sci. J. pmid:28370998
Lu N et al. Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells. 2017 J. Steroid Biochem. Mol. Biol. pmid:28602959
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Kumar P et al. Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis in haplotype male mice. 2017 Am. J. Physiol. Renal Physiol. pmid:28566502
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Wu Q et al. Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications. 2017 J. Ind. Microbiol. Biotechnol. pmid:28536840
Kihara T et al. Bacillus cereus-type polyhydroxyalkanoate biosynthetic gene cluster contains R-specific enoyl-CoA hydratase gene. 2017 Biosci. Biotechnol. Biochem. pmid:28532241
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Donovan JD et al. In Vitro Digestion and Fermentation of Microencapsulated Tributyrin for the Delivery of Butyrate. 2017 J. Food Sci. pmid:28485486
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Suo Y et al. Enhanced butyric acid tolerance and production by Class I heat shock protein-overproducing Clostridium tyrobutyricum ATCC 25755. 2017 J. Ind. Microbiol. Biotechnol. pmid:28439766
Arriaga JM et al. Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells. 2017 Oncol. Rep. pmid:28393194
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Kim YH and Lee JK Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. 2017 Cell. Immunol. pmid:28341057
Egawa G et al. SCFAs Control Skin Immune Responses via Increasing Tregs. 2017 J. Invest. Dermatol. pmid:28340682
Olsen S Effects of ultra-high dilutions of sodium butyrate on viability and gene expression in HEK 293 cells. 2017 Homeopathy pmid:28325222
Zhang J et al. Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from sugarcane juice. 2017 Appl. Microbiol. Biotechnol. pmid:28238080
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Maeshige N et al. Low-Intensity Ultrasound Enhances Histone Acetylation and Inhibition of Interleukin 6 Messenger RNA Expression by the Histone Deacetylase Inhibitor Sodium Butyrate in Fibroblasts. 2017 J Ultrasound Med pmid:28195362
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Nakazawa A et al. Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids. 2017 J. UOEH pmid:28331124
Zhang L et al. Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice. 2017 J. Cell. Biochem. pmid:28109123
Cueno ME et al. Periodontal disease level-butyric acid putatively contributes to the ageing blood: A proposed link between periodontal diseases and the ageing process. 2017 Mech. Ageing Dev. pmid:28108180
Zhou D et al. Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. 2017 World J. Gastroenterol. pmid:28104981
Huang JC et al. [Protective effect of histone acetylation against cortical injury in neonatal rats]. 2017 Zhongguo Dang Dai Er Ke Za Zhi pmid:28100329
Albuquerque Filho MO et al. Dual influences of early-life maternal deprivation on histone deacetylase activity and recognition memory in rats. 2017 Neuroscience pmid:28089578
Kataoka N et al. Butyrate production under aerobic growth conditions by engineered Escherichia coli. 2017 J. Biosci. Bioeng. pmid:28089378
Hichino A et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. 2017 J. Biol. Chem. pmid:28057758
Millat T and Winzer K Mathematical modelling of clostridial acetone-butanol-ethanol fermentation. 2017 Appl. Microbiol. Biotechnol. pmid:28210797
Fu H et al. Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose. 2017 Metab. Eng. pmid:28040464
Jin X et al. TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment. 2017 Cancer Med pmid:28033672
Dai H et al. Sodium Butyrate Ameliorates High-Concentrate Diet-Induced Inflammation in the Rumen Epithelium of Dairy Goats. 2017 J. Agric. Food Chem. pmid:28032994
Johnstone M et al. Characterization of the Pro-Inflammatory Cytokine IL-1β on Butyrate Oxidation in Colorectal Cancer Cells. 2017 J. Cell. Biochem. pmid:27922186
Shirasugi M et al. Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. 2017 Biochem. Biophys. Res. Commun. pmid:27914813
Yan JK et al. Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells. 2017 Biochem. Biophys. Res. Commun. pmid:27888107
Schwarz A et al. The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. 2017 J. Invest. Dermatol. pmid:27887954
Ra CH et al. Hyper-thermal acid hydrolysis and adsorption treatment of red seaweed, Gelidium amansii for butyric acid production with pH control. 2017 Bioprocess Biosyst Eng pmid:27878375
Herrick KJ et al. Single-dose infusion of sodium butyrate, but not lactose, increases plasma β-hydroxybutyrate and insulin in lactating dairy cows. 2017 J. Dairy Sci. pmid:27837980
Moens F et al. Lactate- and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans. 2017 Int. J. Food Microbiol. pmid:27810444
Zhang C et al. Differential effect of early antibiotic intervention on bacterial fermentation patterns and mucosal gene expression in the colon of pigs under diets with different protein levels. 2017 Appl. Microbiol. Biotechnol. pmid:27913852
Dong W et al. Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC. 2017 J. Endocrinol. pmid:27799462
Meneses-Reyes JC et al. Biochemical methane potential of oil-extracted microalgae and glycerol in co-digestion with chicken litter. 2017 Bioresour. Technol. pmid:27864134
Zhang K et al. Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. 2017 Appl. Biochem. Biotechnol. pmid:27832512
Wang YQ et al. Enhancement of acetate productivity in a thermophilic (55 °C) hollow-fiber membrane biofilm reactor with mixed culture syngas (H/CO) fermentation. 2017 Appl. Microbiol. Biotechnol. pmid:28110397
Chriett S et al. The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1. 2017 Mol. Cell. Endocrinol. pmid:27619406
Kumar G et al. Microbial responses to various process disturbances in a continuous hydrogen reactor fed with galactose. 2017 J. Biosci. Bioeng. pmid:27614820