butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Huang C et al. | Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets. | 2015 | J. Nutr. | pmid:26491121 |
Luo H et al. | Enhancing Butanol Production under the Stress Environments of Co-Culturing Clostridium acetobutylicum/Saccharomyces cerevisiae Integrated with Exogenous Butyrate Addition. | 2015 | PLoS ONE | pmid:26489085 |
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Wang X et al. | Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway. | 2015 | Sci Rep | pmid:26234821 |
Steckert AV et al. | Effects of sodium butyrate on aversive memory in rats submitted to sepsis. | 2015 | Neurosci. Lett. | pmid:25888815 |
Castino MR et al. | Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats. | 2015 | PLoS ONE | pmid:25880762 |
Ulfina GG et al. | Modulation of post-partum reproductive performance in dairy cows through supplementation of long- or short-chain fatty acids during transition period. | 2015 | J Anim Physiol Anim Nutr (Berl) | pmid:25879374 |
Shimizu T et al. | Volume-sensitive outwardly rectifying Cl(-) channels contribute to butyrate-triggered apoptosis of murine colonic epithelial MCE301 cells. | 2015 | J Physiol Sci | pmid:25544596 |
Tiwari P et al. | Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. | 2015 | Chem. Biol. Interact. | pmid:25478867 |
Pawelka AJ and Huizinga JD | Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540235 |
Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
Ãvila M et al. | Application of high pressure processing for controlling Clostridium tyrobutyricum and late blowing defect on semi-hard cheese. | 2016 | Food Microbiol. | pmid:27554159 |
Walia K et al. | Effect of feeding sodium butyrate in the late finishing period on Salmonella carriage, seroprevalence, and growth of finishing pigs. | 2016 | Prev. Vet. Med. | pmid:27544256 |
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Yin F et al. | Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides. | 2016 | PLoS ONE | pmid:27508934 |
Moore JB et al. | The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism. | 2016 | Stem Cells | pmid:27501845 |
Lakhter AJ et al. | Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. | 2016 | J. Biol. Chem. | pmid:27539851 |
Fialova B et al. | Epigenetic modulation of AR gene expression in prostate cancer DU145 cells with the combination of sodium butyrate and 5'-Aza-2'-deoxycytidine. | 2016 | Oncol. Rep. | pmid:27499010 |
Foote AP and Freetly HC | Effect of abomasal butyrate infusion on net nutrient flux across the portal-drained viscera and liver of growing lambs. | 2016 | J. Anim. Sci. | pmid:27482683 |
Terova G et al. | Effects of Sodium Butyrate Treatment on Histone Modifications and the Expression of Genes Related to Epigenetic Regulatory Mechanisms and Immune Response in European Sea Bass (Dicentrarchus Labrax) Fed a Plant-Based Diet. | 2016 | PLoS ONE | pmid:27471849 |
Jawed K et al. | Engineered Production of Short Chain Fatty Acid in Escherichia coli Using Fatty Acid Synthesis Pathway. | 2016 | PLoS ONE | pmid:27466817 |
Gargari G et al. | Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults. | 2016 | Appl. Environ. Microbiol. | pmid:27451450 |
Teixeira C et al. | Effects of variety and steeping conditions on some barley components associated with colonic health. | 2016 | J. Sci. Food Agric. | pmid:27450418 |
Zhou J et al. | Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats. | 2016 | Lipids Health Dis | pmid:27449927 |
Astakhova L et al. | Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells. | 2016 | PLoS ONE | pmid:27441625 |
Bai G et al. | Dietary Casein and Soy Protein Isolate Modulate the Effects of Raffinose and Fructooligosaccharides on the Composition and Fermentation of Gut Microbiota in Rats. | 2016 | J. Food Sci. | pmid:27434756 |
Hou G et al. | Tetracycline removal and effect on the formation and degradation of extracellular polymeric substances and volatile fatty acids in the process of hydrogen fermentation. | 2016 | Bioresour. Technol. | pmid:27070285 |
Reijnders D et al. | Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial. | 2016 | Cell Metab. | pmid:27411009 |
Longpré J et al. | Impact of mash feeding versus pellets on propionic/butyric acid levels and on total load in the gastrointestinal tract of growing pigs. | 2016 | J. Anim. Sci. | pmid:27065267 |
Zeng J et al. | Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway. | 2016 | Cell Cycle | pmid:27259983 |
Wang A et al. | Sodium butyrate mitigates in vitro ammonia generation in cecal content of laying hens. | 2016 | Environ Sci Pollut Res Int | pmid:27154844 |
Kapuvári B et al. | Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice. | 2016 | Invest New Drugs | pmid:27146514 |
Wu Y et al. | Influence of Butyrate Loaded Clinoptilolite Dietary Supplementation on Growth Performance, Development of Intestine and Antioxidant Capacity in Broiler Chickens. | 2016 | PLoS ONE | pmid:27104860 |
Rivera-Chávez F et al. | Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. | 2016 | Cell Host Microbe | pmid:27078066 |
Lazarova DL and Bordonaro M | Vimentin, colon cancer progression and resistance to butyrate and other HDACis. | 2016 | J. Cell. Mol. Med. | pmid:27072512 |
Early JV et al. | Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis. | 2016 | Antimicrob. Agents Chemother. | pmid:27044545 |
He B et al. | Effects of sodium butyrate supplementation on reproductive performance and colostrum composition in gilts. | 2016 | Animal | pmid:27040131 |
Petry FS et al. | Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction. | 2016 | Behav. Brain Res. | pmid:27025446 |
Frycz BA et al. | Transcript level of AKR1C3 is down-regulated in gastric cancer. | 2016 | Biochem. Cell Biol. | pmid:27019068 |
Li H et al. | Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice. | 2016 | Brain Res. | pmid:27017959 |
Ortega JF et al. | Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein. | 2016 | Oncotarget | pmid:27013579 |
Sjöblom M et al. | Catalytic upgrading of butyric acid towards fine chemicals and biofuels. | 2016 | FEMS Microbiol. Lett. | pmid:26994015 |
Zhao Z et al. | Potential enhancement of direct interspecies electron transfer for syntrophic metabolism of propionate and butyrate with biochar in up-flow anaerobic sludge blanket reactors. | 2016 | Bioresour. Technol. | pmid:26967338 |
Sun J et al. | Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. | 2016 | Neurosci. Lett. | pmid:26957230 |
Su CL et al. | Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression. | 2016 | J Psychiatr Res | pmid:26921875 |
Tanaka S et al. | Relationship of Enhanced Butyrate Production by Colonic Butyrate-Producing Bacteria to Immunomodulatory Effects in Normal Mice Fed an Insoluble Fraction of Brassica rapa L. | 2016 | Appl. Environ. Microbiol. | pmid:26921420 |
Donovan JD et al. | Volatile Retention and Morphological Properties of Microencapsulated Tributyrin Varied by Wall Material and Drying Method. | 2016 | J. Food Sci. | pmid:26878682 |
Zhang J et al. | Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis. | 2016 | PLoS ONE | pmid:26784903 |
Cang S et al. | Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells. | 2016 | J Hematol Oncol | pmid:26759222 |
Kaczmarek SA et al. | Effect of different doses of coated butyric acid on growth performance and energy utilization in broilers. | 2016 | Poult. Sci. | pmid:26740137 |
Jung JM et al. | Pseudo catalytic transformation of volatile fatty acids into fatty acid methyl esters. | 2016 | Bioresour. Technol. | pmid:26720136 |
Xin F et al. | Strategies for production of butanol and butyl-butyrate through lipase-catalyzed esterification. | 2016 | Bioresour. Technol. | pmid:26710347 |
Ng CH and Yang KL | Lipase in biphasic alginate beads as a biocatalyst for esterification of butyric acid and butanol in aqueous media. | 2016 | Enzyme Microb. Technol. | pmid:26672465 |
Han A et al. | Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. | 2016 | J. Cell. Physiol. | pmid:26661480 |
Tiwari P et al. | Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs. | 2016 | Biochimie | pmid:26655363 |
Valvassori SS et al. | Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain. | 2016 | Psychiatry Res | pmid:26654753 |
Mátis G et al. | Feed-drug interaction of orally applied butyrate and phenobarbital on hepatic cytochrome P450 activity in chickens. | 2016 | J Anim Physiol Anim Nutr (Berl) | pmid:26614344 |
Luceri C et al. | Effect of butyrate enemas on gene expression profiles and endoscopic/histopathological scores of diverted colorectal mucosa: A randomized trial. | 2016 | Dig Liver Dis | pmid:26607831 |
Kratsman N et al. | Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model. | 2016 | Neuropharmacology | pmid:26577018 |
Heidor R et al. | The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis. | 2016 | Mol Nutr Food Res | pmid:26548572 |
Cibis KG et al. | Isolation of acetic, propionic and butyric acid-forming bacteria from biogas plants. | 2016 | J. Biotechnol. | pmid:26779817 |
Cueno ME and Ochiai K | Re-discovering periodontal butyric acid: New insights on an old metabolite. | 2016 | Microb. Pathog. | pmid:26466516 |
Junicke H et al. | Kinetic and thermodynamic control of butyrate conversion in non-defined methanogenic communities. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26403924 |
Ayers LW et al. | Changes in dam and pup behavior following repeated postnatal exposure to a predator odor (TMT): A preliminary investigation in Long-Evans rats. | 2016 | Dev Psychobiol | pmid:26394891 |
Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
Russo R et al. | Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice. | 2016 | Pharmacol. Res. | pmid:26675718 |
Reddy YS et al. | Study on Synthesis, Characterization and Antiproliferative Activity of Novel Diisopropylphenyl Esters of Selected Fatty Acids. | 2016 | J Oleo Sci | pmid:26666272 |
Polycarpo GV et al. | Effects of lipid sources, lysophospholipids and organic acids in maize-based broiler diets on nutrient balance, liver concentration of fat-soluble vitamins, jejunal microbiota and performance. | 2016 | Br. Poult. Sci. | pmid:27494540 |
Kim M et al. | Butyric acid production from softwood hydrolysate by acetate-consuming Clostridium sp. S1 with high butyric acid yield and selectivity. | 2016 | Bioresour. Technol. | pmid:27474955 |
Xing X et al. | Sodium butyrate protects against oxidative stress in HepG2 cells through modulating Nrf2 pathway and mitochondrial function. | 2016 | J. Physiol. Biochem. | pmid:28600747 |
Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
Liu Y et al. | Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27. | 2016 | Food Funct | pmid:27713965 |
Zhang Y et al. | Monitoring Intracellular pH Change with a Genetically Encoded and Ratiometric Luminescence Sensor in Yeast and Mammalian Cells. | 2016 | Methods Mol. Biol. | pmid:27424899 |
MartÃn Juárez J et al. | Saccharification of microalgae biomass obtained from wastewater treatment by enzymatic hydrolysis. Effect of alkaline-peroxide pretreatment. | 2016 | Bioresour. Technol. | pmid:27372005 |
Villain H et al. | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice. | 2016 | Sci Rep | pmid:27270584 |
Zhang Q et al. | Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium. | 2016 | Sci Rep | pmid:27264309 |
Xiong H et al. | Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition. | 2016 | Sci Rep | pmid:27230284 |
Anderson NA et al. | Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis. | 2016 | Org. Biomol. Chem. | pmid:27226381 |
Subramanian U et al. | Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice. | 2016 | Physiol. Genomics | pmid:27199456 |
Bastiaansen JA et al. | Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate. | 2016 | Sci Rep | pmid:27150735 |
Seki K et al. | Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression. | 2016 | Apoptosis | pmid:26994613 |
Vazquez-DeRose J et al. | Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. | 2016 | Brain Struct Funct | pmid:25431268 |
Popp D et al. | The alkaloid gramine in the anaerobic digestion process-inhibition and adaptation of the methanogenic community. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27138201 |
Endesfelder D et al. | Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production. | 2016 | Microbiome | pmid:27114075 |
Park MJ and Sohrabji F | The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. | 2016 | J Neuroinflammation | pmid:27905989 |
Gallo A et al. | Relationships among ensiling, nutritional, fermentative, microbiological traits and contamination in corn silages addressed with partial least squares regression. | 2016 | J. Anim. Sci. | pmid:27898868 |
Estensoro I et al. | Dietary Butyrate Helps to Restore the Intestinal Status of a Marine Teleost (Sparus aurata) Fed Extreme Diets Low in Fish Meal and Fish Oil. | 2016 | PLoS ONE | pmid:27898676 |
Chang MC et al. | Effect of Butyrate on Collagen Expression, Cell Viability, Cell Cycle Progression and Related Proteins Expression of MG-63 Osteoblastic Cells. | 2016 | PLoS ONE | pmid:27893752 |
Zhang T et al. | Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice. | 2016 | Nutrients | pmid:27886121 |
Tochio T et al. | An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats. | 2016 | PLoS ONE | pmid:27861621 |
Tian H et al. | Discovery of a Flexible Triazolylbutanoic Acid as a Highly Potent Uric Acid Transporter 1 (URAT1) Inhibitor. | 2016 | Molecules | pmid:27854343 |
Neis EP et al. | Effects of Liver Resection on Hepatic Short-Chain Fatty Acid Metabolism in Humans. | 2016 | PLoS ONE | pmid:27835668 |
Khairy H et al. | The NADH:flavin oxidoreductase Nox from Rhodococcus erythropolis MI2 is the key enzyme of 4,4'-dithiodibutyric acid degradation. | 2016 | Lett. Appl. Microbiol. | pmid:27564089 |
Kong X et al. | Inhibiting excessive acidification using zero-valent iron in anaerobic digestion of food waste at high organic load rates. | 2016 | Bioresour. Technol. | pmid:26998799 |
Bencsik R et al. | Improved transgene expression in doxycycline-inducible embryonic stem cells by repeated chemical selection or cell sorting. | 2016 | Stem Cell Res | pmid:27591479 |
Han R et al. | Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells. | 2016 | Cell. Physiol. Biochem. | pmid:27771718 |