butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Amin MR et al. | Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17540780 |
Parhar K et al. | Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16469826 |
Marcil V et al. | Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12121881 |
Borthakur A et al. | Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16150873 |
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Cuche G et al. | Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11292611 |
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Cao Y et al. | Dietary fiber enhances TGF-β signaling and growth inhibition in the gut. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21454444 |
Saksena S et al. | Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20501436 |
Alrefai WA et al. | Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14525727 |
Perry MD and Sandle GI | Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19407217 |
Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
Venkatraman A et al. | Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12637250 |
Grider JR and Piland BE | The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16973914 |
Schweigel M and Martens H | Anion-dependent Mg2+ influx and a role for a vacuolar H+-ATPase in sheep ruminal epithelial cells. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12606303 |
Vidyasagar S et al. | Role of short-chain fatty acids in colonic HCO(3) secretion. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15677553 |
Pawelka AJ and Huizinga JD | Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540235 |
Hadjiagapiou C et al. | Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15691871 |
Yuan L et al. | Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299602 |
Pender SL et al. | Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11052988 |
Sonoyama K et al. | Upregulation of activin A gene by butyrate in human colon cancer cell lines. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12540370 |