butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sobolewski C et al. | Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. | 2015 | Biomolecules | pmid:26343742 |
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Agarwal U et al. | Role of rumen butyrate in regulation of nitrogen utilization and urea nitrogen kinetics in growing sheep. | 2015 | J. Anim. Sci. | pmid:26020334 |
Gao F et al. | The Effect of Processing Additives on Energetic Disorder in Highly Efficient Organic Photovoltaics: A Case Study on PBDTTT-C-T:PC71 BM. | 2015 | Adv. Mater. Weinheim | pmid:26016473 |
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Liu H et al. | Post-occlusion administration of sodium butyrate attenuates cognitive impairment in a rat model of chronic cerebral hypoperfusion. | 2015 | Pharmacol. Biochem. Behav. | pmid:26013850 |
Wanat P et al. | Short communication: Effect of inclusion rate of microencapsulated sodium butyrate in starter mixture for dairy calves. | 2015 | J. Dairy Sci. | pmid:25648817 |
Gerace E et al. | Interplay between histone acetylation/deacetylation and poly(ADP-ribosyl)ation in the development of ischemic tolerance in vitro. | 2015 | Neuropharmacology | pmid:25623965 |
Barichello T et al. | Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis. | 2015 | Mol. Neurobiol. | pmid:25284351 |
Dengler F et al. | Both butyrate incubation and hypoxia upregulate genes involved in the ruminal transport of SCFA and their metabolites. | 2015 | J Anim Physiol Anim Nutr (Berl) | pmid:24804847 |
Park SO and Park BS | Bifidogenic effect of grain larvae extract on serum lipid, glucose and intestinal microflora in rats. | 2015 | J. Biosci. | pmid:26333397 |
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Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
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Yin F et al. | Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides. | 2016 | PLoS ONE | pmid:27508934 |
Moore JB et al. | The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism. | 2016 | Stem Cells | pmid:27501845 |
Lakhter AJ et al. | Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. | 2016 | J. Biol. Chem. | pmid:27539851 |
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Foote AP and Freetly HC | Effect of abomasal butyrate infusion on net nutrient flux across the portal-drained viscera and liver of growing lambs. | 2016 | J. Anim. Sci. | pmid:27482683 |
Hou G et al. | Tetracycline removal and effect on the formation and degradation of extracellular polymeric substances and volatile fatty acids in the process of hydrogen fermentation. | 2016 | Bioresour. Technol. | pmid:27070285 |
Reijnders D et al. | Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial. | 2016 | Cell Metab. | pmid:27411009 |
Longpré J et al. | Impact of mash feeding versus pellets on propionic/butyric acid levels and on total load in the gastrointestinal tract of growing pigs. | 2016 | J. Anim. Sci. | pmid:27065267 |
Venkataraman A et al. | Variable responses of human microbiomes to dietary supplementation with resistant starch. | 2016 | Microbiome | pmid:27357127 |
Liang B and Fang J | Postnatal Isoflurane Exposure Induces Cognitive Impairment and Abnormal Histone Acetylation of Glutamatergic Systems in the Hippocampus of Adolescent Rats. | 2016 | J. Mol. Neurosci. | pmid:27307148 |
Lee J et al. | Deciphering Clostridium tyrobutyricum Metabolism Based on the Whole-Genome Sequence and Proteome Analyses. | 2016 | MBio | pmid:27302759 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Rephaeli A et al. | Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin-independent manner. | 2016 | Eur J Pharm Sci | pmid:27283485 |
Moreno FS et al. | Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents. | 2016 | Nutr Cancer | pmid:27266713 |
Aguilar EC et al. | Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells. | 2016 | J. Nutr. Biochem. | pmid:27261536 |
Zeng J et al. | Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway. | 2016 | Cell Cycle | pmid:27259983 |
Wang A et al. | Sodium butyrate mitigates in vitro ammonia generation in cecal content of laying hens. | 2016 | Environ Sci Pollut Res Int | pmid:27154844 |
Kapuvári B et al. | Improved in vivo antitumor effect of a daunorubicin - GnRH-III bioconjugate modified by apoptosis inducing agent butyric acid on colorectal carcinoma bearing mice. | 2016 | Invest New Drugs | pmid:27146514 |
Wu Y et al. | Influence of Butyrate Loaded Clinoptilolite Dietary Supplementation on Growth Performance, Development of Intestine and Antioxidant Capacity in Broiler Chickens. | 2016 | PLoS ONE | pmid:27104860 |
Rivera-Chávez F et al. | Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. | 2016 | Cell Host Microbe | pmid:27078066 |
Lazarova DL and Bordonaro M | Vimentin, colon cancer progression and resistance to butyrate and other HDACis. | 2016 | J. Cell. Mol. Med. | pmid:27072512 |
Early JV et al. | Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis. | 2016 | Antimicrob. Agents Chemother. | pmid:27044545 |
He B et al. | Effects of sodium butyrate supplementation on reproductive performance and colostrum composition in gilts. | 2016 | Animal | pmid:27040131 |
Tanaka S et al. | Relationship of Enhanced Butyrate Production by Colonic Butyrate-Producing Bacteria to Immunomodulatory Effects in Normal Mice Fed an Insoluble Fraction of Brassica rapa L. | 2016 | Appl. Environ. Microbiol. | pmid:26921420 |
Donovan JD et al. | Volatile Retention and Morphological Properties of Microencapsulated Tributyrin Varied by Wall Material and Drying Method. | 2016 | J. Food Sci. | pmid:26878682 |
Wang ZT et al. | Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells. | 2016 | Cell. Signal. | pmid:26876786 |
Zounr RA et al. | Improved Gas Chromatographic Determination of Guanidino Compounds Using Isovaleroylacetone and Ethyl Chloroformate as Derivatizing Reagents. | 2016 | Anal Sci | pmid:26860556 |
Wang J et al. | Therapeutic Effect of Histone Deacetylase Inhibitor, Sodium Butyrate, on Allergic Rhinitis In Vivo. | 2016 | DNA Cell Biol. | pmid:26859163 |
Ziegler K et al. | Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4). | 2016 | Arch. Biochem. Biophys. | pmid:26854723 |
Tao Y et al. | Production of Butyrate from Lactate by a Newly Isolated Clostridium sp. BPY5. | 2016 | Appl. Biochem. Biotechnol. | pmid:26842597 |
Zhu P et al. | [Effect and mechanism of inhibition of lipopolysaccharide-induced pulmonary fibrosis by butyric acid]. | 2016 | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | pmid:26805528 |
Sayed M et al. | Selective oxidation of trimethylolpropane to 2,2-bis(hydroxymethyl)butyric acid using growing cells of Corynebacterium sp. ATCC 21245. | 2016 | J. Biotechnol. | pmid:26804932 |
Zhang J et al. | Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis. | 2016 | PLoS ONE | pmid:26784903 |
Cang S et al. | Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells. | 2016 | J Hematol Oncol | pmid:26759222 |
Kaczmarek SA et al. | Effect of different doses of coated butyric acid on growth performance and energy utilization in broilers. | 2016 | Poult. Sci. | pmid:26740137 |
Jung JM et al. | Pseudo catalytic transformation of volatile fatty acids into fatty acid methyl esters. | 2016 | Bioresour. Technol. | pmid:26720136 |
Xin F et al. | Strategies for production of butanol and butyl-butyrate through lipase-catalyzed esterification. | 2016 | Bioresour. Technol. | pmid:26710347 |
Ng CH and Yang KL | Lipase in biphasic alginate beads as a biocatalyst for esterification of butyric acid and butanol in aqueous media. | 2016 | Enzyme Microb. Technol. | pmid:26672465 |
Heidor R et al. | The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis. | 2016 | Mol Nutr Food Res | pmid:26548572 |
Cibis KG et al. | Isolation of acetic, propionic and butyric acid-forming bacteria from biogas plants. | 2016 | J. Biotechnol. | pmid:26779817 |
Cueno ME et al. | Periodontal disease level-butyric acid amounts locally administered in the rat gingival mucosa induce ER stress in the systemic blood. | 2016 | Microb. Pathog. | pmid:26541671 |
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Cueno ME and Ochiai K | Re-discovering periodontal butyric acid: New insights on an old metabolite. | 2016 | Microb. Pathog. | pmid:26466516 |
Junicke H et al. | Kinetic and thermodynamic control of butyrate conversion in non-defined methanogenic communities. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26403924 |
Russo R et al. | Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice. | 2016 | Pharmacol. Res. | pmid:26675718 |
Polycarpo GV et al. | Effects of lipid sources, lysophospholipids and organic acids in maize-based broiler diets on nutrient balance, liver concentration of fat-soluble vitamins, jejunal microbiota and performance. | 2016 | Br. Poult. Sci. | pmid:27494540 |
Kim M et al. | Butyric acid production from softwood hydrolysate by acetate-consuming Clostridium sp. S1 with high butyric acid yield and selectivity. | 2016 | Bioresour. Technol. | pmid:27474955 |
Han M et al. | Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model. | 2016 | Oncotarget | pmid:27880936 |
Rumpagaporn P et al. | Elevated propionate and butyrate in fecal ferments of hydrolysates generated by oxalic acid treatment of corn bran arabinoxylan. | 2016 | Food Funct | pmid:27841429 |
Karthikeyan OP et al. | Hydrolysis-acidogenesis of food waste in solid-liquid-separating continuous stirred tank reactor (SLS-CSTR) for volatile organic acid production. | 2016 | Bioresour. Technol. | pmid:26512860 |
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Liu Y et al. | Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27. | 2016 | Food Funct | pmid:27713965 |
Zhang Y et al. | Monitoring Intracellular pH Change with a Genetically Encoded and Ratiometric Luminescence Sensor in Yeast and Mammalian Cells. | 2016 | Methods Mol. Biol. | pmid:27424899 |
MartÃn Juárez J et al. | Saccharification of microalgae biomass obtained from wastewater treatment by enzymatic hydrolysis. Effect of alkaline-peroxide pretreatment. | 2016 | Bioresour. Technol. | pmid:27372005 |
Villain H et al. | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice. | 2016 | Sci Rep | pmid:27270584 |
Zhang Q et al. | Accelerated dysbiosis of gut microbiota during aggravation of DSS-induced colitis by a butyrate-producing bacterium. | 2016 | Sci Rep | pmid:27264309 |
Xiong H et al. | Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition. | 2016 | Sci Rep | pmid:27230284 |
Anderson NA et al. | Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis. | 2016 | Org. Biomol. Chem. | pmid:27226381 |
Subramanian U et al. | Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice. | 2016 | Physiol. Genomics | pmid:27199456 |
Bastiaansen JA et al. | Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate. | 2016 | Sci Rep | pmid:27150735 |
Seki K et al. | Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression. | 2016 | Apoptosis | pmid:26994613 |
Khan S and Jena G | Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. | 2016 | Chem. Biol. Interact. | pmid:27270450 |
Zhang Z et al. | O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. | 2016 | J. Biol. Chem. | pmid:27231347 |
Vazquez-DeRose J et al. | Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. | 2016 | Brain Struct Funct | pmid:25431268 |
Grimaldi R et al. | Fermentation properties and potential prebiotic activity of Bimuno® galacto-oligosaccharide (65 % galacto-oligosaccharide content) on in vitro gut microbiota parameters. | 2016 | Br. J. Nutr. | pmid:27267934 |
Popp D et al. | The alkaloid gramine in the anaerobic digestion process-inhibition and adaptation of the methanogenic community. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27138201 |
Endesfelder D et al. | Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production. | 2016 | Microbiome | pmid:27114075 |
Kulcsár A et al. | Effects of butyrate on the insulin homeostasis of chickens kept on maize- or wheat-based diets. | 2016 | Acta Vet. Hung. | pmid:27993103 |
Park MJ and Sohrabji F | The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. | 2016 | J Neuroinflammation | pmid:27905989 |
Gallo A et al. | Relationships among ensiling, nutritional, fermentative, microbiological traits and contamination in corn silages addressed with partial least squares regression. | 2016 | J. Anim. Sci. | pmid:27898868 |
Estensoro I et al. | Dietary Butyrate Helps to Restore the Intestinal Status of a Marine Teleost (Sparus aurata) Fed Extreme Diets Low in Fish Meal and Fish Oil. | 2016 | PLoS ONE | pmid:27898676 |
Chang MC et al. | Effect of Butyrate on Collagen Expression, Cell Viability, Cell Cycle Progression and Related Proteins Expression of MG-63 Osteoblastic Cells. | 2016 | PLoS ONE | pmid:27893752 |
Zhang T et al. | Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice. | 2016 | Nutrients | pmid:27886121 |
Tochio T et al. | An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats. | 2016 | PLoS ONE | pmid:27861621 |
Han R et al. | Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells. | 2016 | Cell. Physiol. Biochem. | pmid:27771718 |
Polak U et al. | Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming. | 2016 | Stem Cells Dev. | pmid:27615158 |
Chen WS et al. | Effects of histone deacetylase inhibitor sodium butyrate on heroin seeking behavior in the nucleus accumbens in rats. | 2016 | Brain Res. | pmid:27742468 |
Miao W et al. | Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2. | 2016 | Int J Mol Sci | pmid:27735862 |
Ain QU et al. | Analysis of Differential Efficacy and Affinity of GABA (α1/α2) Selective Modulators. | 2016 | Mol. Pharm. | pmid:27704838 |