butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Briggs S and Freedland RA | Effect of ornithine and lactate on urea synthesis in isolated hepatocytes. | 1976 | Biochem. J. | pmid:1008850 |
Krystosek A and Sachs L | Control of lysozyme induction in the differentiation of myeloid leukemic cells. | 1976 | Cell | pmid:1017012 |
Cai Y et al. | Effect of applying lactic acid bacteria isolated from forage crops on fermentation characteristics and aerobic deterioration of silage. | 1999 | J. Dairy Sci. | pmid:10194670 |
Silvi S et al. | Resistant starch modifies gut microflora and microbial metabolism in human flora-associated rats inoculated with faeces from Italian and UK donors. | 1999 | J. Appl. Microbiol. | pmid:10196757 |
Soldatenkov VA et al. | Sodium butyrate induces apoptosis and accumulation of ubiquitinated proteins in human breast carcinoma cells. | 1998 | Cell Death Differ. | pmid:10200476 |
Bonnotte B et al. | Cancer cell sensitization to fas-mediated apoptosis by sodium butyrate. | 1998 | Cell Death Differ. | pmid:10200499 |
Mitsuhashi H et al. | Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase. | 1999 | Br. J. Pharmacol. | pmid:10205002 |
Tinel M et al. | Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10215635 |
Cuisset L et al. | Quantitative analysis of histone H1 degrees protein synthesis in HTC cells. | 1999 | Eur. J. Biochem. | pmid:10215874 |
Hara H et al. | Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine. | 1999 | J. Nutr. | pmid:10222383 |
Hung WC and Chuang LY | Sodium butyrate enhances STAT 1 expression in PLC/PRF/5 hepatoma cells and augments their responsiveness to interferon-alpha. | 1999 | Br. J. Cancer | pmid:10360647 |
Maclean KN et al. | Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells. | 1998 | Br. J. Biomed. Sci. | pmid:10367403 |
Parodi PW | Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat. | 1999 | J. Dairy Sci. | pmid:10386321 |
Shah M et al. | Selective and reversible blockage of a fatty acid odour response in the olfactory bulb of the frog (Rana temporaria). | 1999 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10386790 |
Mandal M et al. | Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403841 |
Haas MJ et al. | Sodium butyrate-mediated induction of the glycoprotein hormone alpha-subunit gene: requirement for continued protein synthesis, identification of a butyrate-responsive element, and inhibition of promoter activation by 2-deoxyglucose. | 1999 | J. Cell. Biochem. | pmid:10404394 |
Wang LS et al. | Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrate. | 1999 | Br. J. Cancer | pmid:10408408 |
Mitomo H et al. | Biosynthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Burkholderia cepacia D1. | 1999 | Int. J. Biol. Macromol. | pmid:10408637 |
Kamitani H et al. | Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate. | 1999 | Arch. Biochem. Biophys. | pmid:10415110 |
Yasohara Y et al. | Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction. | 1999 | Appl. Microbiol. Biotechnol. | pmid:10422229 |
Prasad KN et al. | Cyclic nucleotides in the regulation of expression of differentiated functions in neuroblastoma cells. | 1976 | J. Natl. Cancer Inst. | pmid:10449 |
Meng S et al. | Short-chain fatty acids and thyroid hormone interact in regulating enterocyte gene transcription. | 1999 | Surgery | pmid:10455897 |
Hurst RD and Clark JB | Butyric acid mediated induction of enhanced transendothelial resistance in an in vitro model blood-brain barrier system. | 1999 | Neurochem. Int. | pmid:10458656 |
Van den Bergh O et al. | Acquisition and extinction of somatic symptoms in response to odours: a Pavlovian paradigm relevant to multiple chemical sensitivity. | 1999 | Occup Environ Med | pmid:10472302 |
Jeanteur P | [Dietary fibre intake and colon cancer]. | 1999 Jul-Aug | Bull Cancer | pmid:10477376 |
Sakata T et al. | Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture. | 1999 | Dig. Dis. Sci. | pmid:10489936 |
Wiechmann AF and Burden MA | Regulation of AA-NAT and HIOMT gene expression by butyrate and cyclic AMP in Y79 human retinoblastoma cells. | 1999 | J. Pineal Res. | pmid:10496148 |
Stahl A et al. | Identification of the major intestinal fatty acid transport protein. | 1999 | Mol. Cell | pmid:10518211 |
Jordan NJ et al. | Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. | 1999 | J. Clin. Invest. | pmid:10525044 |
Guo Z et al. | Secretion of phospholipid transfer protein by human hepatoma cell line, Hep G2, is enhanced by sodium butyrate. | 1999 | J. Nutr. | pmid:10539773 |
Kaiser E et al. | [Investigations on the fermentation quality of silage from low-nitrate green forage]. | 1999 | Arch Tierernahr | pmid:10548978 |
Garrison PM and Denison MS | Analysis of the murine AhR gene promoter. | 2000 | J. Biochem. Mol. Toxicol. | pmid:10561076 |
Tamai I et al. | Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. | 1999 | J. Pharm. Pharmacol. | pmid:10579682 |
Harris LM et al. | Characterization of recombinant strains of the Clostridium acetobutylicum butyrate kinase inactivation mutant: need for new phenomenological models for solventogenesis and butanol inhibition? | 2000 | Biotechnol. Bioeng. | pmid:10581430 |
Pitcher MC et al. | The contribution of sulphate reducing bacteria and 5-aminosalicylic acid to faecal sulphide in patients with ulcerative colitis. | 2000 | Gut | pmid:10601057 |
Simpson EJ et al. | In vivo measurement of colonic butyrate metabolism in patients with quiescent ulcerative colitis. | 2000 | Gut | pmid:10601058 |
Kataoka M et al. | 3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46. | 2000 | Eur. J. Biochem. | pmid:10601844 |
Liu H et al. | Chemo-enzymatic synthesis of the antidepressant duloxetine and its enantiomer. | 2000 | Chirality | pmid:10602263 |
Chai F et al. | Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. | 2000 | Carcinogenesis | pmid:10607727 |
Crew TE et al. | A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. | 2000 | Carcinogenesis | pmid:10607736 |
Watkins SM et al. | Butyric acid and tributyrin induce apoptosis in human hepatic tumour cells. | 1999 | J. Dairy Res. | pmid:10612054 |
Wu GD et al. | High-level expression of I kappa B-beta in the surface epithelium of the colon: in vitro evidence for an immunomodulatory role. | 1999 | J. Leukoc. Biol. | pmid:10614789 |
Zimmermann N et al. | Molecular analysis of CCR-3 events in eosinophilic cells. | 2000 | J. Immunol. | pmid:10623856 |
Rickard KL et al. | Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells. | 2000 | J. Cell. Physiol. | pmid:10623886 |
Pellizzaro C et al. | Cholesteryl butyrate in solid lipid nanospheres as an alternative approach for butyric acid delivery. | 1999 Sep-Oct | Anticancer Res. | pmid:10628332 |
Faber J et al. | Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia. | 2000 | Arch. Pathol. Lab. Med. | pmid:10629138 |
Barshishat M et al. | Butyrate regulates E-cadherin transcription, isoform expression and intracellular position in colon cancer cells. | 2000 | Br. J. Cancer | pmid:10638989 |
Hu Z et al. | Transcriptional activation of the MDR1 gene by UV irradiation. Role of NF-Y and Sp1. | 2000 | J. Biol. Chem. | pmid:10644769 |
Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
Kleerebezem R and Stams AJ | Kinetics of syntrophic cultures: a theoretical treatise on butyrate fermentation. | 2000 | Biotechnol. Bioeng. | pmid:10649228 |
Ho LH et al. | Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652229 |
Wang XM et al. | Inhibition of proliferation, invasion and adhesion of liver cancer cells by 5-azacytidine and butyrate. | 1999 Jul-Aug | Anticancer Res. | pmid:10652571 |
Chénais B et al. | Oxidative stress involvement in chemically induced differentiation of K562 cells. | 2000 | Free Radic. Biol. Med. | pmid:10656287 |
Buommino E et al. | Sodium butyrate/retinoic acid costimulation induces apoptosis-independent growth arrest and cell differentiation in normal and ras-transformed seminal vesicle epithelial cells unresponsive to retinoic acid. | 2000 | J. Mol. Endocrinol. | pmid:10657000 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
Garrison PM et al. | Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. | 2000 | Arch. Biochem. Biophys. | pmid:10666294 |
Shin JY et al. | Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. | 2000 | Cancer Res. | pmid:10667572 |
Wakabayashi K et al. | Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period. | 2000 Mar-Apr | Oncol. Rep. | pmid:10671672 |
Kamitani H et al. | A GATA binding site is involved in the regulation of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line, caco-2. | 2000 | FEBS Lett. | pmid:10675566 |
Davis MG et al. | Involvement of Gialpha2 in sodium butyrate-induced erythroblastic differentiation of K562 cells. | 2000 | Biochem. J. | pmid:10677366 |
Wächtershäuser A et al. | Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679282 |
Viallard JF et al. | Different expression profiles of human cyclin B1 in normal PHA-stimulated T lymphocytes and leukemic T cells. | 2000 | Cytometry | pmid:10679729 |
Papanikolaou S et al. | High production of 1,3-propanediol from industrial glycerol by a newly isolated Clostridium butyricum strain. | 2000 | J. Biotechnol. | pmid:10682279 |
Greenwood RH et al. | Effects of base ingredient in cooked molasses blocks on intake and digestion of prairie hay by beef steers. | 2000 | J. Anim. Sci. | pmid:10682818 |
Lin YL et al. | Infection of five human liver cell lines by dengue-2 virus. | 2000 | J. Med. Virol. | pmid:10686026 |
Dasgupta P and Mukherjee R | Lipophilization of somatostatin analog RC-160 with long chain fatty acid improves its antiproliferative and antiangiogenic activity in vitro. | 2000 | Br. J. Pharmacol. | pmid:10694208 |
Hayashi Y et al. | SN-1, a novel leukemic cell line with t(11;16)(q23;p13): myeloid characteristics and resistance to retinoids and vitamin D3. | 2000 | Cancer Res. | pmid:10706136 |
Schweigel M et al. | Mechanisms of Mg(2+) transport in cultured ruminal epithelial cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10712259 |
Kido Y et al. | Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. | 2000 | Pharm. Res. | pmid:10714609 |
Ahmad MS et al. | Butyrate and glucose metabolism by colonocytes in experimental colitis in mice. | 2000 | Gut | pmid:10716678 |
Siavoshian S et al. | Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. | 2000 | Gut | pmid:10716680 |
Moalic S et al. | Enhanced apoptosis in retrovirally transfected osteosarcoma cells after exposure to sodium butyrate. | 2000 | Int. J. Oncol. | pmid:10717237 |
Kumar VV et al. | Validated HPLC method for determination of PAT-5A, an insulin sensitizing agent, in rat plasma. | 2000 | J Pharm Biomed Anal | pmid:10719907 |
Kien CL et al. | Butyric acid is synthesized by piglets. | 2000 | J. Nutr. | pmid:10720175 |
Kantor PF et al. | The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. | 2000 | Circ. Res. | pmid:10720420 |
Pace BS et al. | Butyrate-inducible elements in the human gamma-globin promoter. | 2000 | Exp. Hematol. | pmid:10720693 |
Chapkin RS et al. | Effect of diet on colonic-programmed cell death: molecular mechanism of action. | 2000 | Toxicol. Lett. | pmid:10720760 |
Swamy SM and Tan BK | Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. | 2000 | J Ethnopharmacol | pmid:10720783 |
Zeitlin PL | Pharmacologic restoration of delta F508 CFTR-mediated chloride current. | 2000 | Kidney Int. | pmid:10720936 |
Ikeda S et al. | Phospholipid/fatty acid-induced secondary structural change in beta-lactoglobulin during heat-induced gelation. | 2000 | J. Agric. Food Chem. | pmid:10725122 |
Henry F et al. | Role of antigen-presenting cells in long-term antitumor response based on tumor-derived apoptotic body vaccination. | 1999 | Pathobiology | pmid:10725809 |
Crane JK | Redistribution of cyclic GMP in response to sodium butyrate in colon cells. | 2000 | Arch. Biochem. Biophys. | pmid:10729202 |
Anisimov AG et al. | [Changes in the K562 cell sensitivity to nonspecific lysis by human and rat leukocytes under the influence of sodium butyrate, dimethyl sulfoxide and phorbol-12-myristate-13-acetate]. | 2000 Jan-Feb | Ontogenez | pmid:10732363 |
Witt O et al. | Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. | 2000 | Blood | pmid:10733512 |
Wang CH et al. | Transcriptional repression of p21((Waf1/Cip1/Sdi1)) gene by c-jun through Sp1 site. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733944 |
Inan MS et al. | The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. | 2000 | Gastroenterology | pmid:10734024 |
Russo GL et al. | Protective effects of butyric acid in colon cancer. | 1999 | Adv. Exp. Med. Biol. | pmid:10736622 |
D'Argenio G and Mazzacca G | Short-chain fatty acid in the human colon. Relation to inflammatory bowel diseases and colon cancer. | 1999 | Adv. Exp. Med. Biol. | pmid:10736623 |
Barton HA et al. | Family approach for estimating reference concentrations/doses for series of related organic chemicals. | 2000 | Toxicol. Sci. | pmid:10746952 |
Courilleau D et al. | B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts. | 2000 | J. Biol. Chem. | pmid:10747961 |
Gillenwater A et al. | Effects of sodium butyrate on growth, differentiation, and apoptosis in head and neck squamous carcinoma cell lines. | 2000 | Head Neck | pmid:10748448 |
Nikiforov AA et al. | [UV-induced immobilization of DNA repair protein XPA in different human cell line]. | 2000 | Tsitologiia | pmid:10752124 |
Küsel K et al. | Clostridium scatologenes strain SL1 isolated as an acetogenic bacterium from acidic sediments. | 2000 | Int. J. Syst. Evol. Microbiol. | pmid:10758858 |
Broda DM et al. | Clostridium algidixylanolyticum sp. nov., a psychrotolerant, xylan-degrading, spore-forming bacterium. | 2000 | Int. J. Syst. Evol. Microbiol. | pmid:10758868 |
Matthies C et al. | Pelospora glutarica gen. nov., sp. nov., a glutarate-fermenting, strictly anaerobic, spore-forming bacterium. | 2000 | Int. J. Syst. Evol. Microbiol. | pmid:10758871 |
Sekiguchi Y et al. | Syntrophothermus lipocalidus gen. nov., sp. nov., a novel thermophilic, syntrophic, fatty-acid-oxidizing anaerobe which utilizes isobutyrate. | 2000 | Int. J. Syst. Evol. Microbiol. | pmid:10758888 |
Kuhner CH et al. | Clostridium akagii sp. nov. and Clostridium acidisoli sp. nov.: acid-tolerant, N2-fixing clostridia isolated from acidic forest soil and litter. | 2000 | Int. J. Syst. Evol. Microbiol. | pmid:10758899 |
Ackerman CJ et al. | Pretanned leather shavings in a supplement mixture for steers: I. In situ and in vitro disappearance, ruminal fermentation, and organic matter, nitrogen, and fiber digestion. | 2000 | J. Anim. Sci. | pmid:10764081 |
Domenica Cappellini M et al. | Oral isobutyramide therapy in patients with thalassemia intermedia: results of a phase II open study. | 2000 | Blood Cells Mol. Dis. | pmid:10772882 |