butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Palmer DG et al. | Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate. | 1997 | Int. J. Cancer | pmid:9398049 |
Vimard C et al. | Changes in the sedimentation properties of acetycholinesterase during neuroblastoma differentiation. | 1976 | Biochimie | pmid:938691 |
Hassig CA et al. | Fiber-derived butyrate and the prevention of colon cancer. | 1997 | Chem. Biol. | pmid:9384528 |
Onaga T et al. | Effect of pituitary adenylate cyclase-activating polypeptide on exocrine and endocrine secretion in the ovine pancreas. | 1996 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9375356 |
Coradini D et al. | Effect of sodium butyrate on human breast cancer cell lines. | 1997 Mar-Apr | Cell Prolif. | pmid:9375027 |
Faller DV and Perrine SP | Butyrate in the treatment of sickle cell disease and beta-thalassemia. | 1995 | Curr. Opin. Hematol. | pmid:9371980 |
Kolesnitchenko V et al. | A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis. | 1997 | J. Virol. | pmid:9371641 |
Velázquez OC et al. | Butyrate inhibits deoxycholate-induced increase in colonic mucosal DNA and protein synthesis in vivo. | 1997 | Dis. Colon Rectum | pmid:9369115 |
Payne KL et al. | Modulation of T3-induced sex hormone-binding globulin secretion by human hepatoblastoma cells. | 1997 | Eur. J. Endocrinol. | pmid:9368511 |
Singh M | Calcium and cyclic nucleotide interaction in secretion of amylase from rat pancreas in vitro. | 1979 | J. Physiol. (Lond.) | pmid:93637 |
Velázquez OC and Rombeau JL | Butyrate. Potential role in colon cancer prevention and treatment. | 1997 | Adv. Exp. Med. Biol. | pmid:9361842 |
Velázquez OC et al. | Butyrate and the colonocyte. Production, absorption, metabolism, and therapeutic implications. | 1997 | Adv. Exp. Med. Biol. | pmid:9361838 |
Barnard JA et al. | Short chain fatty acid regulation of intestinal gene expression. | 1997 | Adv. Exp. Med. Biol. | pmid:9361821 |
O'Mara FP et al. | Rumen fermentation and nutrient flows for cows fed grass and grass supplemented with molassed beet pulp pellets. | 1997 | J. Dairy Sci. | pmid:9361218 |
Kavaliers M et al. | Opioid and non-opioid NMDA-mediated predator-induced analgesia in mice and the effects of parasitic infection. | 1997 | Brain Res. | pmid:9359582 |
Loukopoulos D | New therapies for the haemoglobinopathies. | 1997 | J Intern Med Suppl | pmid:9350181 |
Vecchia MG et al. | Acetate and propionate potentiate the antiproliferative effect of butyrate on RBL-2H3 growth. | 1997 | Gen. Pharmacol. | pmid:9347317 |
Garcia-Bermejo L et al. | Modulation of heat-shock protein 70 (HSP70) gene expression by sodium butyrate in U-937 promonocytic cells: relationships with differentiation and apoptosis. | 1997 | Exp. Cell Res. | pmid:9344607 |
Sovová V et al. | Differences of alkaline phosphatase and arginase activities in human colorectal carcinoma cell lines. | 1997 | Folia Biol. (Praha) | pmid:9338115 |
Janson W et al. | Butyrate modulates DNA-damage-induced p53 response by induction of p53-independent differentiation and apoptosis. | 1997 | Oncogene | pmid:9333015 |
Kaiser E and Weiss K | [Fermentation process during the ensiling of green forage low in nitrate. 2. Fermentation process after supplementation of nitrate, nitrite, lactic acid bacteria and formic acid]. | 1997 | Arch Tierernahr | pmid:9324922 |
Scannell JP et al. | Antimetabolites produced by microorganisms. XIII. The synthesis and microbiological production of a novel amino acid, L-2-amino-4-(2-aminoethoxy) butanoic acid. | 1976 | J. Antibiot. | pmid:931793 |
Engelhard HH et al. | Molecular characterization of glioblastoma cell differentiation. | 1997 | Neurosurgery | pmid:9316051 |
Dohi H et al. | Intake stimulants in perennial ryegrass (Lolium perenne L.) fed to sheep. | 1997 | J. Dairy Sci. | pmid:9313150 |
Hague A et al. | bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis. | 1997 | Int. J. Cancer | pmid:9311611 |
Ishiguro K and Sartorelli AC | Clonal variability in beta-globin mRNA content in an interleukin-3-dependent bone marrow cell line transfected with the erythropoietin receptor before and after stimulation with erythropoietin. | 1997 | Blood | pmid:9310478 |
Birkett AM et al. | Dietary intake and faecal excretion of carbohydrate by Australians: importance of achieving stool weights greater than 150 g to improve faecal markers relevant to colon cancer risk. | 1997 | Eur J Clin Nutr | pmid:9306090 |
Cuisset L et al. | The effects of sodium butyrate on transcription are mediated through activation of a protein phosphatase. | 1997 | J. Biol. Chem. | pmid:9305863 |
Chénais B et al. | Time-course of butyric acid-induced differentiation in human K562 leukemic cell line: rapid increase in gamma-globin, porphobilinogen deaminase and NF-E2 mRNA levels. | 1997 | Leukemia | pmid:9305615 |
Lewis SJ and Heaton KW | Increasing butyrate concentration in the distal colon by accelerating intestinal transit. | 1997 | Gut | pmid:9301506 |
Ohno Y et al. | Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9294201 |
Talley NA et al. | Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial. | 1997 | Dis. Colon Rectum | pmid:9293933 |
Medina V et al. | Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway. | 1997 | Cancer Res. | pmid:9288776 |
Chen ZJ and Pikaard CS | Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance. | 1997 | Genes Dev. | pmid:9284051 |
Kenyon E et al. | Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium. | 1997 | Am. J. Physiol. | pmid:9277343 |
De Visser H et al. | Nutrient fluxes in splanchnic tissue of dairy cows: influence of grass quality. | 1997 | J. Dairy Sci. | pmid:9276806 |
Humbert G et al. | Method for the measurement of lipase activity in milk. | 1997 | J. Dairy Res. | pmid:9275261 |
Simon B et al. | Transient transcriptional activation of gastrin during sodium butyrate-induced differentiation of islet cells. | 1997 | Regul. Pept. | pmid:9272626 |
Xiao H et al. | Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9268733 |
Nakano K et al. | Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. | 1997 | J. Biol. Chem. | pmid:9268365 |
Tai G et al. | Different effects of cyclic AMP and butyrate on eosinophilic differentiation, apoptosis and bcl-2 expression of a human eosinophilic leukemia cell line, EoL-1. | 1996 | Hematol Oncol | pmid:9267464 |
Navarro JM et al. | Differentiation of BCS-TC2 human colon adenocarcinoma cells by sodium butyrate: increase in 5'-nucleotidase activity. | 1997 | Eur. J. Clin. Invest. | pmid:9263751 |
Qin S and Yamamura H | Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9245716 |
Jacobasch G and Jacobasch KH | [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. | 1997 | Z Arztl Fortbild Qualitatssich | pmid:9244653 |
Kaeffer B et al. | Treatment of rat proximal and distal colonic cells with sodium orthovanadate enhances their adhesion and survival in primary culture. | 1997 | Cell Biol. Int. | pmid:9243806 |
Siavoshian S et al. | Comparison of the effect of different short chain fatty acids on the growth and differentiation of human colonic carcinoma cell lines in vitro. | 1997 | Cell Biol. Int. | pmid:9243803 |
Ferry AE et al. | Globin gene silencing in primary erythroid cultures. An inhibitory role for interleukin-6. | 1997 | J. Biol. Chem. | pmid:9242673 |
Millais AJ et al. | The biotransformation of t-butylacetonitrile and its boron-containing analogue trimethylamine-cyanoborane by Brevibacterium R312. | 1997 | Arch. Microbiol. | pmid:9238109 |
Erickson KD and Martin JM | Early detection of the lytic LMP-1 protein in EBV-infected B-cells suggests its presence in the virion. | 1997 | Virology | pmid:9234942 |
Atkins KB et al. | Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation. | 1997 | Arch. Biochem. Biophys. | pmid:9224725 |