butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Talley NA et al. | Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial. | 1997 | Dis. Colon Rectum | pmid:9293933 |
Ohno Y et al. | Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9294201 |
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Birkett AM et al. | Dietary intake and faecal excretion of carbohydrate by Australians: importance of achieving stool weights greater than 150 g to improve faecal markers relevant to colon cancer risk. | 1997 | Eur J Clin Nutr | pmid:9306090 |
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Palmer DG et al. | Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate. | 1997 | Int. J. Cancer | pmid:9398049 |
Cordel S et al. | 5-Fluorouracil-resistant colonic tumors are highly responsive to sodium butyrate/interleukin-2 bitherapy in rats. | 1997 | Int. J. Cancer | pmid:9399677 |
Moore JW et al. | Thiolmethyltransferase activity in the human colonic mucosa: implications for ulcerative colitis. | 1997 | J. Gastroenterol. Hepatol. | pmid:9407333 |
Böhmig GA et al. | n-butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: a potential mechanism for modulating T-cell responses by short-chain fatty acids. | 1997 | Immunology | pmid:9415032 |
Callus BA et al. | Haemoglobin synthesis in erythropoietin-stimulated J2E cells does not require increased numbers of transferrin receptors. | 1997 | Eur. J. Biochem. | pmid:9428699 |
Yabushita H et al. | Emergence of an irreversible differentiated subclone from the poorly differentiated ovarian adenocarcinoma cell line AMOC-2 treated with sodium butyrate. | 1997 | J. Obstet. Gynaecol. Res. | pmid:9433040 |
Ono M et al. | Resin glycosides. XXV. Multifidins I and II, new jalapins, from the seed of Quamoclit x multifida. | 1997 | Chem. Pharm. Bull. | pmid:9433765 |
Medina V et al. | Sodium butyrate inhibits carcinoma development in a 1,2-dimethylhydrazine-induced rat colon cancer. | 1998 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:9437648 |
Gupta KP and Mehrotra NK | Differential effects of butyric acid on mouse skin tumorigenesis. | 1997 | Biomed. Environ. Sci. | pmid:9448925 |
Perez-Esteban J et al. | Lipase activity of Pseudomonas fluorescens in cold raw skim milk with different lipid supplements. | 1997 | Folia Microbiol. (Praha) | pmid:9449781 |
Leber BF and Denburg JA | Retinoic acid modulation of induced basophil differentiation. | 1997 | Allergy | pmid:9450139 |
Saleh AW and Hillen HF | Pharmacological induction of foetal haemoglobin synthesis in sickle-cell disease. | 1997 | Neth J Med | pmid:9455096 |
Llorente A et al. | Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus. | 1998 | J. Cell Biol. | pmid:9456316 |
Gillenwater A et al. | Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate. | 1998 | Int. J. Cancer | pmid:9462711 |
Shimizu A et al. | CyclinG contributes to G2/M arrest of cells in response to DNA damage. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9464250 |
Yamane M et al. | Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2. | 1998 | Cancer Lett. | pmid:9464491 |
Yamamoto I et al. | Interleukin-2-dependent augmentation of the anti-TNP antibody production by sodium butyrate in cultured murine splenic B cells. | 1997 | Int. J. Immunopharmacol. | pmid:9467754 |
Dong-Le Bourhis X et al. | Transforming growth factor beta 1 and sodium butyrate differentially modulate urokinase plasminogen activator and plasminogen activator inhibitor-1 in human breast normal and cancer cells. | 1998 | Br. J. Cancer | pmid:9472634 |
Umenishi F and Verkman AS | Isolation of the human aquaporin-1 promoter and functional characterization in human erythroleukemia cell lines. | 1998 | Genomics | pmid:9480747 |
Dumas D et al. | Effect of glutaraldehyde on hemoglobin-dependent quenching of pyrene fluorescence. Application to oxygen diffusion in erythrocyte. | 1997 Jul-Aug | Clin. Hemorheol. Microcirc. | pmid:9493896 |
Lawrence C and Grossman R | Simple butyrate esterase stain for monocytes. | 1979 | Stain Technol | pmid:94951 |
Emiliani S et al. | Characterization of a human RPD3 ortholog, HDAC3. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501169 |
Ritzhaupt A et al. | The characterization of butyrate transport across pig and human colonic luminal membrane. | 1998 | J. Physiol. (Lond.) | pmid:9508842 |
Moore-Hoon ML and Turner RJ | Increased expression of the secretory Na+-K+-2Cl- cotransporter with differentiation of a human intestinal cell line. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514875 |
Basson MD et al. | Differential modulation of human (Caco-2) colon cancer cell line phenotype by short chain fatty acids. | 1998 | Proc. Soc. Exp. Biol. Med. | pmid:9521097 |
Nathan I et al. | Alterations in membrane lipid dynamics of leukemic cells undergoing growth arrest and differentiation: dependency on the inducing agent. | 1998 | Exp. Cell Res. | pmid:9521862 |
Johnstone RM et al. | Loss of glucose transport in developing avian red cells. | 1998 | Eur. J. Cell Biol. | pmid:9523157 |
Charney AN et al. | Nonionic diffusion of short-chain fatty acids across rat colon. | 1998 | Am. J. Physiol. | pmid:9530153 |
Komatsu Y and Hayashi H | Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells. | 1998 | J. Antibiot. | pmid:9531994 |
Kondo A et al. | Detection of antitumor promoting activity in Raji cells carrying Epstein-Barr virus genome by immunoblotting analysis. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9532799 |
Giardina C and Inan MS | Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells. | 1998 | Biochim. Biophys. Acta | pmid:9540818 |
Hasegawa S et al. | Sickling of nucleated erythroid precursors from patients with sickle cell anemia. | 1998 | Exp. Hematol. | pmid:9546314 |
Barka T | Effect of sodium butyrate on the expression of genes transduced by retroviral vectors. | 1998 | J. Cell. Biochem. | pmid:9548567 |
Krishnan S et al. | The ability of enteric diarrhoeal pathogens to ferment starch to short-chain fatty acids in vitro. | 1998 | Scand. J. Gastroenterol. | pmid:9548615 |
Krishnan S and Ramakrishna BS | Butyrate and glucose metabolism in isolated colonocytes in the developing rat colon. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552140 |
Yabuuchi H et al. | Possible role of anion exchanger AE2 as the intestinal monocarboxylic acid/anion antiporter. | 1998 | Pharm. Res. | pmid:9563070 |
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Kondo K et al. | Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. | 1998 | Cancer Res. | pmid:9581847 |
Zhang M et al. | Heat-induced proteolysis of HSF causes premature deactivation of the heat shock response in Nb2 lymphoma cells. | 1998 | Cell Stress Chaperones | pmid:9585182 |
Clark PR et al. | A novel drug screening assay for papillomavirus specific antiviral activity. | 1998 | Antiviral Res. | pmid:9588842 |
Fukushima K et al. | Sodium butyrate-induced liver-type alkaline phosphatase activity in a small intestinal epithelial cell line, IEC6. | 1998 | Dig. Dis. Sci. | pmid:9590430 |
Matthews JB et al. | Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate. | 1998 | J. Clin. Invest. | pmid:9593763 |
Walia H et al. | Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA. | 1998 | J. Biol. Chem. | pmid:9603965 |
Cuisset L et al. | A protein phosphatase is involved in the inhibition of histone deacetylation by sodium butyrate. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9618285 |
Archer SY et al. | p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9618491 |
Perez RV et al. | Selective targeting of Kupffer cells with liposomal butyrate augments portal venous transfusion-induced immunosuppression. | 1998 | Transplantation | pmid:9625008 |
Yamamoto H et al. | Suppression of growth of hepatocellular carcinoma by sodium butyrate in vitro and in vivo. | 1998 | Int. J. Cancer | pmid:9626359 |
Smith JG et al. | Butyric acid from the diet: actions at the level of gene expression. | 1998 | Crit Rev Food Sci Nutr | pmid:9626487 |
Tsumura H et al. | Mouse alloantigen Ly10 is identical to murine fusion regulatory protein-1 (mFRP-1)/4F2/CD98: aberrant expression of mFRP-1/Ly10 allotypes in cells derived from CDF1 mice due to the gene deletion. | 1998 | Cell. Immunol. | pmid:9630841 |
Caderni G et al. | Slow-release pellets of sodium butyrate increase apoptosis in the colon of rats treated with azoxymethane, without affecting aberrant crypt foci and colonic proliferation. | 1998 | Nutr Cancer | pmid:9631487 |
Santini V et al. | Butyrate-stable monosaccharide derivatives induce maturation and apoptosis in human acute myeloid leukaemia cells. | 1998 | Br. J. Haematol. | pmid:9633898 |
Wang XM et al. | Effects of 5-azacytidine and butyrate on differentiation and apoptosis of hepatic cancer cell lines. | 1998 | Ann. Surg. | pmid:9637556 |
George CH et al. | Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647771 |
Dangond F and Gullans SR | Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647779 |
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Jacobs HC et al. | Fetal lung mRNA levels of Hox genes are differentially altered by maternal diabetes and butyrate in rats. | 1998 | Pediatr. Res. | pmid:9667378 |
Itoh F et al. | Effects of heat exposure on plasma insulin, glucagon and metabolites in response to nutrient injection in heifers. | 1998 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9669085 |
Zhang J et al. | Energy metabolism of rat colonocytes changes during the tumorigenic process and is dependent on diet and carcinogen. | 1998 | J. Nutr. | pmid:9687542 |
Nishimura A et al. | Short-chain fatty acids regulate IGF-binding protein secretion by intestinal epithelial cells. | 1998 | Am. J. Physiol. | pmid:9688874 |
Holtbäck U et al. | Neuropeptide Y shifts equilibrium between alpha- and beta-adrenergic tonus in proximal tubule cells. | 1998 | Am. J. Physiol. | pmid:9688998 |
von Engelhardt W et al. | Role of short-chain fatty acids in the hind gut. | 1998 | Vet Q | pmid:9689727 |
Nakano K et al. | [A novel approach for cancer chemoprevention referred to as "gene-regulating chemoprevention"]. | 1998 | Nihon Geka Gakkai Zasshi | pmid:9695075 |
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