butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Fang HH and Liu H | Effect of pH on hydrogen production from glucose by a mixed culture. | 2002 | Bioresour. Technol. | pmid:11858207 |
Hulin SJ et al. | Sulphide-induced energy deficiency in colonic cells is prevented by glucose but not by butyrate. | 2002 | Aliment. Pharmacol. Ther. | pmid:11860416 |
Vien J et al. | trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. | 2002 | Br. J. Pharmacol. | pmid:11861315 |
Hyman R | Lack of a consistent relationship between demethylation of the CD44 promoter and CD44 expression. | 2002 | Immunogenetics | pmid:11862392 |
Andoh A et al. | Sodium butyrate enhances complement-mediated cell injury via down-regulation of decay-accelerating factor expression in colonic cancer cells. | 2002 | Cancer Immunol. Immunother. | pmid:11862418 |
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Hergenhahn M et al. | The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells. | 2002 | Mol. Carcinog. | pmid:11870879 |
Shin R et al. | Influence of intestinal anaerobes and organic acids on the growth of enterohaemorrhagic Escherichia coli O157:H7. | 2002 | J. Med. Microbiol. | pmid:11871614 |
Farajzadeh M and Mardani A | Analysis of residual solvents in ampicillin powder by headspace spectrophotometric method. | 2002 | Anal Sci | pmid:11874121 |
Nakagawa J et al. | Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. | 2002 | J. Biol. Chem. | pmid:11882650 |
Cuff MA et al. | Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. | 2002 | J. Physiol. (Lond.) | pmid:11882670 |
Lebrun-Garcia A et al. | Questioning the role of salicylic acid and cytosolic acidification in mitogen-activated protein kinase activation induced by cryptogein in tobacco cells. | 2002 | Planta | pmid:11882949 |
Park NS et al. | The crystal structure of KR-21042, an analgesic capsaicinoid. | 2002 | Arch. Pharm. Res. | pmid:11887880 |
Domon-Dell C et al. | Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells. | 2002 | Gut | pmid:11889074 |
Tyagi S et al. | Mechanism of n-butyrate uptake in the human proximal colonic basolateral membranes. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11897627 |
Izco JM et al. | Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores. | 2002 | J. Agric. Food Chem. | pmid:11902910 |
Faust D et al. | Butyrate and the cytokine-induced alpha1-proteinase inhibitor release in intestinal epithelial cells. | 2001 | Eur. J. Clin. Invest. | pmid:11903492 |
Jalc D and Ceresnáková Z | Effect of plant oils and aspartate on rumen fermentation in vitro. | 2001 | J Anim Physiol Anim Nutr (Berl) | pmid:11906562 |
Jones SL et al. | Correlation of long-range membrane order with temperature-dependent growth characteristics of parent and a cold-sensitive, branched-chain-fatty-acid-deficient mutant of Listeria monocytogenes. | 2002 | Arch. Microbiol. | pmid:11907677 |
Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. | 2001 | Brain Tumor Pathol | pmid:11908866 |
Cessna AJ and Grover R | Exposure of ground-rig applicators to the herbicide bromoxynil applied as a 1:1 mixture of butyrate and octanoate. | 2002 | Arch. Environ. Contam. Toxicol. | pmid:11910467 |
Van Reeth T et al. | Stimulation of the alpha-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation. | 2002 | Mol. Cell. Endocrinol. | pmid:11911950 |
Decruse SW and Seeni S | Ammonium nitrate in the culture medium influences regeneration potential of cryopreserved shoot tips of Holostemma annulare. | 2002 Jan-Feb | Cryo Letters | pmid:11912508 |
Kamitani H et al. | Histone acetylation may suppress human glioma cell proliferation when p21 WAF/Cip1 and gelsolin are induced. | 2002 | Neuro-oncology | pmid:11916500 |
Yang J et al. | Modifying the chain-length selectivity of the lipase from Burkholderia cepacia KWI-56 through in vitro combinatorial mutagenesis in the substrate-binding site. | 2002 | Protein Eng. | pmid:11917151 |
Neu J and Bernstein H | Update on host defense and immunonutrients. | 2002 | Clin Perinatol | pmid:11917739 |
Tan S et al. | Proteome analysis of butyrate-treated human colon cancer cells (HT-29). | 2002 | Int. J. Cancer | pmid:11920611 |
Ewton DZ et al. | Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. | 2002 | Int. J. Cancer | pmid:11920634 |
Kim H et al. | Gas-phase analysis of trimethylamine, propionic and butyric acids, and sulfur compounds using solid-phase microextraction. | 2002 | Anal. Chem. | pmid:11924963 |
Schneider IC et al. | Fermentation of cottonseed and other feedstuffs in cattle rumen fluid. | 2002 | J. Agric. Food Chem. | pmid:11929282 |
Brune A et al. | Ilyobacter insuetus sp. nov., a fermentative bacterium specialized in the degradation of hydroaromatic compounds. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:11931152 |
Soto-Cruz O et al. | Modeling of growth, lactate consumption, and volatile fatty acid production by Megasphaera elsdenii cultivated in minimal and complex media. | Biotechnol. Prog. | pmid:11934285 | |
Boatright JH et al. | The effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells. | 2002 | Vision Res. | pmid:11934446 |
Pitarque M et al. | Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents. | 2002 | Environ. Health Perspect. | pmid:11940458 |
Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
Cuff MA and Shirazi-Beechey SP | The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944921 |
Heinz S et al. | Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. | 2002 | Genomics | pmid:11944995 |
Clarke KO et al. | Exposure to a deuterated analogue of phenylbutyrate retards S-phase progression in HT-29 colon cancer cells. | 2002 | J Pharm Sci | pmid:11948544 |
Luongo D et al. | Down-regulation of ERK1 and ERK2 activity during differentiation of the intestinal cell line HT-29. | 2002 | Mol. Cell. Biochem. | pmid:11952164 |
Jenkins WL and Davis LE | A method for the in vitro study of drug transfer across ruminal epithelium. | 1975 | J S Afr Vet Assoc | pmid:1195266 |
Kurita-Ochiai T et al. | Human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis. | 2002 | Infect. Immun. | pmid:11953371 |
Scheffer GL et al. | Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein. | 2002 | Br. J. Cancer | pmid:11953829 |
Greenbaum L et al. | Nuclear distribution of porphobilinogen deaminase (PBGD) in glioma cells: a regulatory role in cancer transformation? | 2002 | Br. J. Cancer | pmid:11953837 |
Maring JG et al. | Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. | 2002 | Br. J. Cancer | pmid:11953843 |
Lambert DW et al. | Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. | 2002 | Br. J. Cancer | pmid:11953883 |
Tsubaki J et al. | Differential activation of the IGF binding protein-3 promoter by butyrate in prostate cancer cells. | 2002 | Endocrinology | pmid:11956160 |
Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
Volova TG et al. | Autotrophic synthesis of polyhydroxyalkanoates by the bacteria Ralstonia eutropha in the presence of carbon monoxide. | 2002 | Appl. Microbiol. Biotechnol. | pmid:11956753 |
Miles RD et al. | Evidence for a transition state analog, MgADP-aluminum fluoride-acetate, in acetate kinase from Methanosarcina thermophila. | 2002 | J. Biol. Chem. | pmid:11960978 |
Oliver L et al. | Resistance to apoptosis is increased during metastatic dissemination of colon cancer. | 2002 | Clin. Exp. Metastasis | pmid:11964082 |
Haschke G et al. | Effect of butyrate on membrane potential, ionic currents and intracellular Ca2+ concentration in cultured rat myenteric neurones. | 2002 | Neurogastroenterol. Motil. | pmid:11975713 |
Diakos C et al. | Novel mode of interference with nuclear factor of activated T-cells regulation in T-cells by the bacterial metabolite n-butyrate. | 2002 | J. Biol. Chem. | pmid:11983691 |
Moreau NM et al. | Predominance of caecal injury in a new dextran sulphate sodium treatment in rats: histopathological and fermentative characteristics. | 2002 | Eur J Gastroenterol Hepatol | pmid:11984152 |
Huber D et al. | Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. | 2002 | Blood | pmid:11986218 |
Gélébart P et al. | Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. | 2002 | J. Biol. Chem. | pmid:11986315 |
Horiuchi JI et al. | Selective production of organic acids in anaerobic acid reactor by pH control. | 2002 | Bioresour. Technol. | pmid:11991067 |
Yadava RN and Sodhi S | A new flavone glycoside: 5,7,3',4'-tetrahydroxy-3-methoxy flavone-7-O-beta-D-galactopyranosyl-(1-->4)-O-beta-D-glucopyranoside from the stem of Acacia catechu Willd. | 2002 | J Asian Nat Prod Res | pmid:11991187 |
Nancey S et al. | Butyrate strongly inhibits in vitro stimulated release of cytokines in blood. | 2002 | Dig. Dis. Sci. | pmid:11991629 |
Richard D et al. | Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species. | 2002 | FEBS Lett. | pmid:11997038 |
Pellegrini S et al. | A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product. | 2002 | Biochim. Biophys. Acta | pmid:11997086 |
Han H et al. | Carbohydrate fermentation and nitrogen metabolism of a finishing beef diet by ruminal microbes in continuous cultures as affected by ethoxyquin and(or) supplementation of monensin and tylosin. | 2002 | J. Anim. Sci. | pmid:12002320 |
Canganella F et al. | Clostridium thermobutyricum: growth studies and stimulation of butyrate formation by acetate supplementation. | 2002 | Microbiol. Res. | pmid:12002403 |
Shaw RN et al. | Induction of human herpesvirus 8 gene expression in a posttransplantation primary effusion lymphoma cell line. | 2002 | Leuk. Lymphoma | pmid:12002770 |
Welters CF et al. | Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch-anal anastomosis. | 2002 | Dis. Colon Rectum | pmid:12004211 |
Drozdowski LA et al. | Short-chain fatty acids and total parenteral nutrition affect intestinal gene expression. | JPEN J Parenter Enteral Nutr | pmid:12005453 | |
Golzio M et al. | Cell synchronization effect on mammalian cell permeabilization and gene delivery by electric field. | 2002 | Biochim. Biophys. Acta | pmid:12007621 |
Araki Y et al. | In vitro alterations in fecal short chain fatty acids and organic anions induced by the destruction of intestinal microflora under hypotonic and aerobic conditions. | 2002 | Int. J. Mol. Med. | pmid:12011980 |
Yokoyama T et al. | Capillary electrophoretic separation between Fe(II) and Ni(II) precomplexed with 1,10-phenanthroline in a high concentration buffer of n-butyric acid/ n-butyrate and its application. | 2002 | Anal Bioanal Chem | pmid:12012197 |
Nafday SM et al. | Vitamin A supplementation ameliorates butyric acid-induced intestinal mucosal injury in newborn rats. | 2002 | J Perinat Med | pmid:12012631 |
Le Leu RK et al. | Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat. | 2002 | Carcinogenesis | pmid:12016142 |
Pellizzaro C et al. | Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29. | 2002 | Carcinogenesis | pmid:12016145 |
Wong PA et al. | Production of specific copolymers of polyhydroxyalkanoates from industrial waste. | 2002 | Appl. Biochem. Biotechnol. | pmid:12018290 |
Kim JK et al. | Mass production of methane from food wastes with concomitant wastewater treatment. | 2002 | Appl. Biochem. Biotechnol. | pmid:12018299 |
Ichikawa H et al. | Gastric or rectal instillation of short-chain fatty acids stimulates epithelial cell proliferation of small and large intestine in rats. | 2002 | Dig. Dis. Sci. | pmid:12018914 |
Macha S and Mitra AK | Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis. | 2002 | Drug Metab. Dispos. | pmid:12019194 |
Beaulieu AD et al. | Isolated canine and murine intestinal cells exhibit a different pattern of fuel utilization for oxidative metabolism. | 2002 | J. Anim. Sci. | pmid:12019609 |
Akay V et al. | NutriDense and waxy corn hybrids: effects on site and extent of disappearance of nutrients in sheep. | 2002 | J. Anim. Sci. | pmid:12019623 |
Kihara M and Sakata T | Production of short-chain fatty acids and gas from various oligosaccharides by gut microbes of carp (Cyprinus carpio L.) in micro-scale batch culture. | 2002 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:12020649 |
Kang DG et al. | Effects of bulb of Fritillaria ussuriensis maxim. on angiotensin converting enzyme and vascular release of NO/cGMP in rats. | 2002 | J Ethnopharmacol | pmid:12020927 |
Doble MA et al. | Luminal regulation of Na(+)/H(+) exchanger gene expression in rat ileal mucosa. | J. Gastrointest. Surg. | pmid:12022991 | |
Mikkelsen IM et al. | The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. | 2002 | Mol. Cell. Biochem. | pmid:12030384 |
Kwon YB et al. | The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. | 2002 | Life Sci. | pmid:12031688 |
Buyse M et al. | Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. | 2002 | J. Biol. Chem. | pmid:12034734 |
Byers JA | Internet programs for drawing moth pheromone analogs and searching literature database. | 2002 | J. Chem. Ecol. | pmid:12035928 |
Tominaga K et al. | Genetics of cellular senescence. | 2002 | Mech. Ageing Dev. | pmid:12044941 |
Kashefi K et al. | Geoglobus ahangari gen. nov., sp. nov., a novel hyperthermophilic archaeon capable of oxidizing organic acids and growing autotrophically on hydrogen with Fe(III) serving as the sole electron acceptor. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12054231 |
van der Wielen PW et al. | Clostridium lactatifermen tans sp. nov., a lactate-fermenting anaerobe isolated from the caeca of a chicken. | 2002 | Int. J. Syst. Evol. Microbiol. | pmid:12054258 |
Tabuchi Y et al. | Identification of genes responsive to sodium butyrate in colonic epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054516 |
Kinoshita M et al. | Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054544 |
Freese E et al. | Correlation between the growth inhibitory effects, partition coefficients and teratogenic effects of lipophilic acids. | 1979 | Teratology | pmid:120615 |
Rahmani M et al. | The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. | 2002 | Exp. Cell Res. | pmid:12061815 |
Schwiertz A et al. | Influence of resistant starch on the SCFA production and cell counts of butyrate-producing Eubacterium spp. in the human intestine. | 2002 | J. Appl. Microbiol. | pmid:12067385 |
Wu S et al. | Interferon-alpha (Intron A) upregulates urokinase-type plasminogen activator receptor gene expression. | 2002 | Cancer Immunol. Immunother. | pmid:12070711 |