butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

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Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Psychophysiologic Disorders D011602 3 associated lipids
Radiation Injuries D011832 14 associated lipids
Retinoblastoma D012175 12 associated lipids
Retroviridae Infections D012192 4 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Salivary Gland Neoplasms D012468 1 associated lipids
Sarcoma 180 D012510 21 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Osteosarcoma D012516 50 associated lipids
Seizures D012640 87 associated lipids
Starvation D013217 47 associated lipids
Thalassemia D013789 8 associated lipids
Thrombosis D013927 49 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Trophoblastic Neoplasms D014328 1 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Uremia D014511 33 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Dementia, Vascular D015140 7 associated lipids
Gastrinoma D015408 1 associated lipids
Weight Gain D015430 101 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
HIV Infections D015658 20 associated lipids
Pleural Effusion, Malignant D016066 6 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Lymphoma, AIDS-Related D016483 2 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Strongylida Infections D017206 5 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Hepatoblastoma D018197 10 associated lipids
Teratocarcinoma D018243 7 associated lipids
Adenocarcinoma, Follicular D018263 3 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Multiple Chemical Sensitivity D018777 4 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Pouchitis D019449 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Epstein-Barr Virus Infections D020031 3 associated lipids
Enterocolitis, Necrotizing D020345 3 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Genomic Instability D042822 7 associated lipids
Diverticulosis, Colonic D043963 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Urea Cycle Disorders, Inborn D056806 2 associated lipids
Prostatic Neoplasms, Castration-Resistant D064129 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

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Authors Title Published Journal PubMed Link
Asai S et al. Quantitative analysis of the Epstein-Barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria. 1991 Arch. Virol. pmid:1652240
Liang CY et al. High efficiency gene transfer into mammalian kidney cells using baculovirus vectors. 2004 Arch. Virol. pmid:14689275
Adolf GR et al. Spontaneous production of alpha- and beta-interferon in human lymphoblastoid and lymphoma cell lines. 1982 Arch. Virol. pmid:6180703
Radsak K et al. Induction by sodium butyrate of cytomegalovirus replication in human endothelial cells. 1989 Arch. Virol. pmid:2552958
Roubalová K et al. Effects of activated serum factor on the induction of Epstein-Barr virus antigens and cell differentiation. 1985 Arch. Virol. pmid:2990391
Asai S et al. Ultrastructural studies on cell fusion induced by Epstein-Barr virus or N-butyrate and 12-O-tetradecanoylphorbol-13-acetate. Brief report. 1985 Arch. Virol. pmid:2998304
Fujita R et al. An HDAC inhibitor increases AcMNPV gene expression in mammalian cells. 2010 Arch. Virol. pmid:20186445
Horz HP and Conrads G The discussion goes on: What is the role of Euryarchaeota in humans? 2010 Archaea pmid:21253553
Ranganna K et al. Sodium butyrate inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7489253
Grabiec AM et al. Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? 2008 Arthritis Res. Ther. pmid:18983693
Kawabata T et al. Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis. 2010 Arthritis Res. Ther. pmid:20609223
Mort JS Histone deacetylases--a new target for suppression of cartilage degradation? 2005 Arthritis Res. Ther. pmid:15987498
de Grauw JC et al. A targeted lipidomics approach to the study of eicosanoid release in synovial joints. 2011 Arthritis Res. Ther. pmid:21794148
Young DA et al. Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. 2005 Arthritis Res. Ther. pmid:15899037
Fukae J et al. Butyrate suppresses tumor necrosis factor alpha production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element. 2005 Arthritis Rheum. pmid:16142751
Tayebi B et al. Modulation of microRNAs expression in hematopoietic stem cells treated with sodium butyrate in inducing fetal hemoglobin expression. 2017 Artif Cells Nanomed Biotechnol pmid:26837891
AteÅŸ S et al. Enhanced ethyl butyrate production using immobilized lipase. 2013 Artif Cells Nanomed Biotechnol pmid:23305408
Honecker VH and Coper H [Stability of amphetaminil. 1. In-vitro studies]. 1975 Arzneimittelforschung pmid:1174051
Celasco G et al. Pharmacological profile of 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04), a new androgen antagonist with antigonadotropic activity. 2005 Arzneimittelforschung pmid:16294504
Nozawa S et al. In vitro and in vivo induction of squamous cell carcinoma antigen (SCC) in a uterine cervical cancer cell line (SKG-IIIa) with peplomycin and sodium butyrate. 1990 Asia Oceania J Obstet Gynaecol pmid:1696099
Patten GS et al. Effects of convenience rice congee supplemented diets on guinea pig whole animal and gut growth, caecal digesta SCFA and in vitro ileal contractility. 2004 Asia Pac J Clin Nutr pmid:15003921
Okoye TC et al. Evaluation of the acute and sub acute toxicity of Annona senegalensis root bark extracts. 2012 Asian Pac J Trop Med pmid:22449518
Priyashree S et al. Bronchodilatory and mast cell stabilising activity of Cressa cretica L.: evaluation through in vivo and in vitro experimental models. 2012 Asian Pac J Trop Med pmid:22305781
Ettebong EO et al. In vivo antiplasmodial activities of ethanolic extract and fractions of Eleucine indica. 2012 Asian Pac J Trop Med pmid:22805716
Chinasa EC et al. Evaluation of anti-inflammatory property of the leaves of Sansevieria liberica ger. and labr. (fam: Dracaenaceae). 2011 Asian Pac J Trop Med pmid:22014734
Nabandith V et al. Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat. Asian Pac. J. Cancer Prev. pmid:15546251
Gandhi GK et al. Hyperglycaemia and diabetes impair gap junctional communication among astrocytes. 2010 ASN Neuro pmid:20396375
Furukawa M et al. Epstein-Barr virus early antigen induction in nasopharyngeal hybrid cells by Chinese medicinal herbs. 1986 Auris Nasus Larynx pmid:3028348
Furukawa M and Umeda R Inhibitory effect of retinoid (E5166) on cell growth and suppressive effect on Epstein-Barr virus early-antigen induction by n-butyrate in nasopharyngeal hybrid cells. 1987 Auris Nasus Larynx pmid:2820366
Arcus AC et al. Studies with the autotransplanted ovine pancreas: glucagon and insulin secretion. 1976 Aust. J. Biol. Sci. pmid:791227
Packer EL et al. Rumen fermentation and liveweight gain in beef cattle treated with monensin and grazing lush forage. 2011 Aust. Vet. J. pmid:21864305
Pedersen G et al. Cultures of human colonic epithelial cells isolated from endoscopical biopsies from patients with inflammatory bowel disease. Effect of IFNgamma, TNFalpha and IL-1beta on viability, butyrate oxidation and IL-8 secretion. 2000 Autoimmunity pmid:11191284
Ping W et al. Baculovirus-mediated gene expression in chicken primary cells. 2006 Avian Dis. pmid:16617983
Henriksen M et al. Evaluation of PCR and DNA sequencing for direct detection of Clostridium perfringens in the intestinal tract of broilers. 2009 Avian Dis. pmid:19848086
Van Immerseel F et al. Interactions of butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro. 2004 Apr-Jun Avian Dis. pmid:15283426
Timbermont L et al. Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. 2010 Avian Pathol. pmid:20390546
Van Deun K et al. Short-chain fatty acids and L-lactate as feed additives to control Campylobacter jejuni infections in broilers. 2008 Avian Pathol. pmid:18622853
Ishihara K et al. Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19486331
Podzuweit T et al. Cyclic AMP mediated arrhythmias induced in the ischaemic pig heart. 1981 Jul-Aug Basic Res. Cardiol. pmid:6116488
Moretti M et al. Behavioral and neurochemical effects of sodium butyrate in an animal model of mania. 2011 Behav Pharmacol pmid:21989497
Resende WR et al. Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer. 2013 Behav Pharmacol pmid:23994816
Petry FS et al. Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction. 2016 Behav. Brain Res. pmid:27025446
Horii Y et al. Exposure to TMT odor affects adrenal sympathetic nerve activity and behavioral consequences in rats. 2010 Behav. Brain Res. pmid:20595033
Sharma S et al. Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: Modulation of histone deacetylase activity. 2015 Behav. Brain Res. pmid:26048426
Yang J et al. Inhibition of nuclear factor-κB impairs reconsolidation of morphine reward memory in rats. 2011 Behav. Brain Res. pmid:20816896
Ayers LW et al. Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal deafferentation. 2013 Behav. Brain Res. pmid:23831303
Kalda A et al. Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice. 2007 Behav. Brain Res. pmid:17477979
Reolon GK et al. Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. 2011 Behav. Brain Res. pmid:21421011
Zhu H et al. Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: involvement of 5-HT(1A) receptors. 2009 Behav. Brain Res. pmid:18817816
Watanabe T et al. Green odor and depressive-like state in rats: toward an evidence-based alternative medicine? 2011 Behav. Brain Res. pmid:21684308
Wallace KJ and Rosen JB Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces. 2000 Behav. Neurosci. pmid:11085605
Lattal KM et al. Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. 2007 Behav. Neurosci. pmid:17907845
Zhu Y et al. [In vitro study about the inhibitory effect of CDAII in combination with sodium butyrate on breast cancer cells]. 2007 Beijing Da Xue Xue Bao pmid:17940563
Havenaar R Intestinal health functions of colonic microbial metabolites: a review. 2011 Benef Microbes pmid:21840809
Roelofsen H et al. The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes. 2010 Benef Microbes pmid:21831781
Bird AR et al. Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics. 2010 Benef Microbes pmid:21831780
Binsl TW et al. Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. 2010 Benef Microbes pmid:21831778
Mäkeläinen H et al. Xylo-oligosaccharides enhance the growth of bifidobacteria and Bifidobacterium lactis in a simulated colon model. 2010 Benef Microbes pmid:21831753
Mäkivuokko H et al. Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model. 2010 Benef Microbes pmid:21840801
Fernando WM et al. Diets supplemented with chickpea or its main oligosaccharide component raffinose modify faecal microbial composition in healthy adults. 2010 Benef Microbes pmid:21831757
Fürll M et al. [Hormonal reactions in fattening bulls and cows during a three-week butyric acid exposure]. 1993 Berl. Munch. Tierarztl. Wochenschr. pmid:8267563
Fürll M et al. [Effect of a three-week butyric acid exposure on the mineral metabolism and the skeletal system in cattle]. 1993 Berl. Munch. Tierarztl. Wochenschr. pmid:8267564
Ichikawa N et al. Production, purification and characterization of the plasminogen activator in teratocarcinoma stem cells induced with sodium butyrate. 1984 Biken J pmid:6443174
Nikolić N et al. Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells. 2012 Biochem Res Int pmid:21904680
Iwalokun BA et al. Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus: An African Mistletoe. 2011 Biochem Res Int pmid:21918720
George CH et al. Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins. 1998 Biochem. Biophys. Res. Commun. pmid:9647771
Dangond F and Gullans SR Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. 1998 Biochem. Biophys. Res. Commun. pmid:9647779
Filippovich I et al. Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA. 1994 Biochem. Biophys. Res. Commun. pmid:7904816
Kitzis A et al. Effect of sodium butyrate on chromatin structure. 1980 Biochem. Biophys. Res. Commun. pmid:7387680
Tong X et al. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. 2004 Biochem. Biophys. Res. Commun. pmid:15063780
Nagelberg SB et al. Pretranslational regulation of ectopic hCG alpha production in ChaGo lung cancer cells by sodium butyrate. 1985 Biochem. Biophys. Res. Commun. pmid:2417603
Bohan C et al. Sodium butyrate activates human immunodeficiency virus long terminal repeat--directed expression. 1987 Biochem. Biophys. Res. Commun. pmid:2825693
Kitzis A et al. Localization of phosphoproteins and of protein kinases in chromatin from butyrate treated HTC cells. 1980 Biochem. Biophys. Res. Commun. pmid:7470113
Gudmundsson GH et al. Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides. 2010 Biochem. Biophys. Res. Commun. pmid:20494122
Oster T et al. Induction of recombinant human gamma-glutamyl transferase by sodium butyrate in transfected V79 and CHO Chinese hamster cells. 1993 Biochem. Biophys. Res. Commun. pmid:8099285
Kwa FA et al. Chlorambucil-sensitive and -resistant lymphoid cells display different responses to the histone deacetylase inhibitor, sodium butyrate. 2010 Biochem. Biophys. Res. Commun. pmid:21075074
Heo H et al. Suppression of caspase-11 expression by histone deacetylase inhibitors. 2009 Biochem. Biophys. Res. Commun. pmid:19013432
Wiegandt H et al. Retinoic acid alters the metabolic 3H-labelling of glycosphingolipids. 1987 Biochem. Biophys. Res. Commun. pmid:3032172
Mori Y et al. Differential effect of sodium butyrate on cyclic AMP phosphodiesterase activities in butyrate sensitive and resistant mastocytoma cells. 1986 Biochem. Biophys. Res. Commun. pmid:3019329
Siavoshian S et al. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. 1997 Biochem. Biophys. Res. Commun. pmid:9125124
Lee IH et al. Involvement of CCAAT/enhancer-binding protein alpha in haptoglobin gene expression by all-trans-retinoic acid. 2002 Biochem. Biophys. Res. Commun. pmid:12074569
Staecker JL et al. Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by sodium butyrate. 1987 Biochem. Biophys. Res. Commun. pmid:3632683
Arányi T et al. Sodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA. 2007 Biochem. Biophys. Res. Commun. pmid:17524356
Tang DC and Taylor MW Memory of butyrate induction by the Moloney murine sarcoma virus enhancer-promoter element. 1992 Biochem. Biophys. Res. Commun. pmid:1449468
Leibovitch MP et al. Effect of sodium butyrate on gene expression in a rat myogenic cell line. 1984 Biochem. Biophys. Res. Commun. pmid:6517941
Chen TH et al. Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells. 2007 Biochem. Biophys. Res. Commun. pmid:17331472
Qin S and Yamamura H Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage. 1997 Biochem. Biophys. Res. Commun. pmid:9245716
Stevens MS et al. Associated effects of sodium butyrate on histone acetylation and estrogen receptor in the human breast cancer cell line MCF-7. 1984 Biochem. Biophys. Res. Commun. pmid:6704117
Russo GL et al. Down-regulation of protein kinase CKII activity by sodium butyrate. 1997 Biochem. Biophys. Res. Commun. pmid:9168912
Gaschott T et al. 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. 2001 Biochem. Biophys. Res. Commun. pmid:11322770
Zhang Y et al. Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing. 2010 Biochem. Biophys. Res. Commun. pmid:20599756
Carneiro VC et al. The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation. 2009 Biochem. Biophys. Res. Commun. pmid:19879244
Ho LH et al. Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10652229
Prasad MR et al. Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase. 1983 Biochem. Biophys. Res. Commun. pmid:6870879
Belakavadi M et al. Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF. 2005 Biochem. Biophys. Res. Commun. pmid:16105646
Mandal M et al. Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. 1999 Biochem. Biophys. Res. Commun. pmid:10403841
Vider BZ et al. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. 2000 Biochem. Biophys. Res. Commun. pmid:10833444
Han L et al. Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. 2006 Biochem. Biophys. Res. Commun. pmid:16904069
Yano S and Tierney DF Butyrate increases catalase activity and protects rat pulmonary artery smooth muscle cells against hyperoxia. 1989 Biochem. Biophys. Res. Commun. pmid:2590195
Moore-Hoon ML and Turner RJ Increased expression of the secretory Na+-K+-2Cl- cotransporter with differentiation of a human intestinal cell line. 1998 Biochem. Biophys. Res. Commun. pmid:9514875