butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

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Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Osteosarcoma D012516 50 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Sarcoma 180 D012510 21 associated lipids
Salivary Gland Neoplasms D012468 1 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Retroviridae Infections D012192 4 associated lipids
Retinoblastoma D012175 12 associated lipids
Radiation Injuries D011832 14 associated lipids
Psychophysiologic Disorders D011602 3 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Per page 10 20 50 100 | Total 149

PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

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Authors Title Published Journal PubMed Link
Désilets A et al. Inhibition by deacetylase inhibitors of IL-1-dependent induction of haptoglobin involves CCAAT/Enhancer-binding protein isoforms in intestinal epithelial cells. 2000 Biochem. Biophys. Res. Commun. pmid:11027530
George CH et al. Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins. 1998 Biochem. Biophys. Res. Commun. pmid:9647771
Dangond F and Gullans SR Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. 1998 Biochem. Biophys. Res. Commun. pmid:9647779
Filippovich I et al. Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA. 1994 Biochem. Biophys. Res. Commun. pmid:7904816
Rivero JA and Adunyah SE Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. 1998 Biochem. Biophys. Res. Commun. pmid:9703983
Kitzis A et al. Effect of sodium butyrate on chromatin structure. 1980 Biochem. Biophys. Res. Commun. pmid:7387680
Bai L and Merchant JL ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. 2007 Biochem. Biophys. Res. Commun. pmid:17560543
Daniel C et al. p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression. 2004 Biochem. Biophys. Res. Commun. pmid:15504345
Nagelberg SB et al. Pretranslational regulation of ectopic hCG alpha production in ChaGo lung cancer cells by sodium butyrate. 1985 Biochem. Biophys. Res. Commun. pmid:2417603
Seki J et al. Dimethyl sulfoxide and related polar compounds enhance infection of human T cells with HIV-1 in vitro. 1996 Biochem. Biophys. Res. Commun. pmid:8886001
BektaÅŸoÄŸlu B et al. Novel hydroxyl radical scavenging antioxidant activity assay for water-soluble antioxidants using a modified CUPRAC method. 2006 Biochem. Biophys. Res. Commun. pmid:16716257
Otaka M et al. Antibody-mediated targeting of differentiation inducers to tumor cells: inhibition of colonic cancer cell growth in vitro and in vivo. A preliminary note. 1989 Biochem. Biophys. Res. Commun. pmid:2912449
Bohan C et al. Sodium butyrate activates human immunodeficiency virus long terminal repeat--directed expression. 1987 Biochem. Biophys. Res. Commun. pmid:2825693
Fishman PH et al. Induction of glycolipid biosynthesis by sodium butyrate in HeLa cells. 1974 Biochem. Biophys. Res. Commun. pmid:4858378
Lallemand F et al. Direct inhibition of the expression of cyclin D1 gene by sodium butyrate. 1996 Biochem. Biophys. Res. Commun. pmid:8954100
Wächtershäuser A et al. PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. 2000 Biochem. Biophys. Res. Commun. pmid:10833422
Kitzis A et al. Localization of phosphoproteins and of protein kinases in chromatin from butyrate treated HTC cells. 1980 Biochem. Biophys. Res. Commun. pmid:7470113
Oster T et al. Induction of recombinant human gamma-glutamyl transferase by sodium butyrate in transfected V79 and CHO Chinese hamster cells. 1993 Biochem. Biophys. Res. Commun. pmid:8099285
Kitajima M et al. Characterization of baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mammalian cells. 2006 Biochem. Biophys. Res. Commun. pmid:16545777
Weingarten D and de Vellis J Selective inhibition by sodium butyrate of the glucocorticoid induction of glycerol phosphate dehydrogenase in glial cultures. 1980 Biochem. Biophys. Res. Commun. pmid:6772178
TaÅŸtan Bishop AO and Sewell T A new approach to possible substrate binding mechanisms for nitrile hydratase. 2006 Biochem. Biophys. Res. Commun. pmid:16540090
Cuff MA and Shirazi-Beechey SP The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. 2002 Biochem. Biophys. Res. Commun. pmid:11944921
Akiba Y et al. Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. 2010 Biochem. Biophys. Res. Commun. pmid:20170631
Wiegandt H et al. Retinoic acid alters the metabolic 3H-labelling of glycosphingolipids. 1987 Biochem. Biophys. Res. Commun. pmid:3032172
Mori Y et al. Differential effect of sodium butyrate on cyclic AMP phosphodiesterase activities in butyrate sensitive and resistant mastocytoma cells. 1986 Biochem. Biophys. Res. Commun. pmid:3019329
Siavoshian S et al. Butyrate stimulates cyclin D and p21 and inhibits cyclin-dependent kinase 2 expression in HT-29 colonic epithelial cells. 1997 Biochem. Biophys. Res. Commun. pmid:9125124
Ide Y et al. Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer. 2006 Biochem. Biophys. Res. Commun. pmid:16434023
Pasvanis S et al. High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. 2012 Biochem. Biophys. Res. Commun. pmid:22293191
Abramova MV et al. e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes. 2010 Biochem. Biophys. Res. Commun. pmid:19900401
Zgouras D et al. Modulation of angiogenesis-related protein synthesis by valproic acid. 2004 Biochem. Biophys. Res. Commun. pmid:15033455
McMillan L et al. Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. 2000 Biochem. Biophys. Res. Commun. pmid:10873561
Radhakrishnan P et al. Butyrate induces sLex synthesis by stimulation of selective glycosyltransferase genes. 2007 Biochem. Biophys. Res. Commun. pmid:17553459
Lee CH et al. NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin. 2000 Biochem. Biophys. Res. Commun. pmid:10913344
Tang DC and Taylor MW Memory of butyrate induction by the Moloney murine sarcoma virus enhancer-promoter element. 1992 Biochem. Biophys. Res. Commun. pmid:1449468
Leibovitch MP et al. Effect of sodium butyrate on gene expression in a rat myogenic cell line. 1984 Biochem. Biophys. Res. Commun. pmid:6517941
Wei P et al. Reversible immortalization of Nestin-positive precursor cells from pancreas and differentiation into insulin-secreting cells. 2012 Biochem. Biophys. Res. Commun. pmid:22266322
Iacomino G et al. Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. 2001 Biochem. Biophys. Res. Commun. pmid:11478796
Newman JD et al. Induction of the insulin receptor and other differentiation markers by sodium butyrate in the Burkitt lymphoma cell, Raji. 1989 Biochem. Biophys. Res. Commun. pmid:2786417
Koyama N et al. Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. 2002 Biochem. Biophys. Res. Commun. pmid:11944905
Xiao H et al. Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. 1997 Biochem. Biophys. Res. Commun. pmid:9268733
Hatayama H et al. The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T. 2007 Biochem. Biophys. Res. Commun. pmid:17374366
Lee SK et al. Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression. 2005 Biochem. Biophys. Res. Commun. pmid:16202385
Wang CH et al. Transcriptional repression of p21((Waf1/Cip1/Sdi1)) gene by c-jun through Sp1 site. 2000 Biochem. Biophys. Res. Commun. pmid:10733944
Qin S and Yamamura H Up-regulation of Syk activity during HL60 cell differentiation into granulocyte but not into monocyte/macrophage-lineage. 1997 Biochem. Biophys. Res. Commun. pmid:9245716
Cuisset L et al. A protein phosphatase is involved in the inhibition of histone deacetylation by sodium butyrate. 1998 Biochem. Biophys. Res. Commun. pmid:9618285
Adolf GR and Swetly P Effects of butyrate on induction and action of interferon. 1981 Biochem. Biophys. Res. Commun. pmid:6174120
Stevens MS et al. Associated effects of sodium butyrate on histone acetylation and estrogen receptor in the human breast cancer cell line MCF-7. 1984 Biochem. Biophys. Res. Commun. pmid:6704117
Hammill D et al. The D-domain of Sp3 modulates its protein levels and activation of the p21(CIP1/WAF1) promoter. 2005 Biochem. Biophys. Res. Commun. pmid:16081043
Aung CS et al. Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. 2007 Biochem. Biophys. Res. Commun. pmid:17321497
Jahangeer S et al. beta-Adrenergic receptor induction in HeLa cells: synergistic effect of 5-azacytidine and butyrate. 1982 Biochem. Biophys. Res. Commun. pmid:6185119
Laubach VE et al. High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme. 1996 Biochem. Biophys. Res. Commun. pmid:8579595
Abramova MV et al. Selective repression of c-fos gene transcription in rat embryo fibroblasts transformed by oncogenes E1A and cHa-ras. 2003 Biochem. Biophys. Res. Commun. pmid:12804589
Ho LH et al. Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10652229
Kim HS et al. Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. 2003 Biochem. Biophys. Res. Commun. pmid:14651963
Prasad MR et al. Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase. 1983 Biochem. Biophys. Res. Commun. pmid:6870879
Rabelo FL et al. Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate. 2003 Biochem. Biophys. Res. Commun. pmid:12670506
Ramirez ML et al. Chlorambucil-induced changes in chromatin methylation and their modulation by sodium butyrate. 1982 Biochem. Biophys. Res. Commun. pmid:7181918
Heda GD and Marino CR Surface expression of the cystic fibrosis transmembrane conductance regulator mutant DeltaF508 is markedly upregulated by combination treatment with sodium butyrate and low temperature. 2000 Biochem. Biophys. Res. Commun. pmid:10814518
Mandal M et al. Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. 1999 Biochem. Biophys. Res. Commun. pmid:10403841
Shirasugi M et al. Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. 2017 Biochem. Biophys. Res. Commun. pmid:27914813
Vider BZ et al. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. 2000 Biochem. Biophys. Res. Commun. pmid:10833444
Yan JK et al. Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells. 2017 Biochem. Biophys. Res. Commun. pmid:27888107
Zgouras D et al. Butyrate impairs intestinal tumor cell-induced angiogenesis by inhibiting HIF-1alpha nuclear translocation. 2003 Biochem. Biophys. Res. Commun. pmid:12559948
Diakos C et al. n-Butyrate inhibits Jun NH(2)-terminal kinase activation and cytokine transcription in mast cells. 2006 Biochem. Biophys. Res. Commun. pmid:16949031
Bergann T et al. A colonic mineralocorticoid receptor cell model expressing epithelial Na+ channels. 2009 Biochem. Biophys. Res. Commun. pmid:19275887
Han L et al. Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. 2006 Biochem. Biophys. Res. Commun. pmid:16904069
Yano S and Tierney DF Butyrate increases catalase activity and protects rat pulmonary artery smooth muscle cells against hyperoxia. 1989 Biochem. Biophys. Res. Commun. pmid:2590195
Zhao Y et al. Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. 2005 Biochem. Biophys. Res. Commun. pmid:15607742
Nikolić N et al. Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells. 2012 Biochem Res Int pmid:21904680
Iwalokun BA et al. Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus: An African Mistletoe. 2011 Biochem Res Int pmid:21918720
Ichikawa N et al. Production, purification and characterization of the plasminogen activator in teratocarcinoma stem cells induced with sodium butyrate. 1984 Biken J pmid:6443174
Fürll M et al. [Hormonal reactions in fattening bulls and cows during a three-week butyric acid exposure]. 1993 Berl. Munch. Tierarztl. Wochenschr. pmid:8267563
Fürll M et al. [Effect of a three-week butyric acid exposure on the mineral metabolism and the skeletal system in cattle]. 1993 Berl. Munch. Tierarztl. Wochenschr. pmid:8267564
Havenaar R Intestinal health functions of colonic microbial metabolites: a review. 2011 Benef Microbes pmid:21840809
Roelofsen H et al. The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes. 2010 Benef Microbes pmid:21831781
Bird AR et al. Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics. 2010 Benef Microbes pmid:21831780
Binsl TW et al. Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. 2010 Benef Microbes pmid:21831778
Mäkeläinen H et al. Xylo-oligosaccharides enhance the growth of bifidobacteria and Bifidobacterium lactis in a simulated colon model. 2010 Benef Microbes pmid:21831753
Mäkivuokko H et al. Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model. 2010 Benef Microbes pmid:21840801
Fernando WM et al. Diets supplemented with chickpea or its main oligosaccharide component raffinose modify faecal microbial composition in healthy adults. 2010 Benef Microbes pmid:21831757
Zhu Y et al. [In vitro study about the inhibitory effect of CDAII in combination with sodium butyrate on breast cancer cells]. 2007 Beijing Da Xue Xue Bao pmid:17940563
Wallace KJ and Rosen JB Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces. 2000 Behav. Neurosci. pmid:11085605
Lattal KM et al. Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. 2007 Behav. Neurosci. pmid:17907845
Petry FS et al. Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction. 2016 Behav. Brain Res. pmid:27025446
Horii Y et al. Exposure to TMT odor affects adrenal sympathetic nerve activity and behavioral consequences in rats. 2010 Behav. Brain Res. pmid:20595033
Sharma S et al. Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: Modulation of histone deacetylase activity. 2015 Behav. Brain Res. pmid:26048426
Yang J et al. Inhibition of nuclear factor-κB impairs reconsolidation of morphine reward memory in rats. 2011 Behav. Brain Res. pmid:20816896
Ayers LW et al. Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal deafferentation. 2013 Behav. Brain Res. pmid:23831303
Kalda A et al. Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice. 2007 Behav. Brain Res. pmid:17477979
Reolon GK et al. Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. 2011 Behav. Brain Res. pmid:21421011
Zhu H et al. Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: involvement of 5-HT(1A) receptors. 2009 Behav. Brain Res. pmid:18817816
Watanabe T et al. Green odor and depressive-like state in rats: toward an evidence-based alternative medicine? 2011 Behav. Brain Res. pmid:21684308
Moretti M et al. Behavioral and neurochemical effects of sodium butyrate in an animal model of mania. 2011 Behav Pharmacol pmid:21989497
Resende WR et al. Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer. 2013 Behav Pharmacol pmid:23994816
Podzuweit T et al. Cyclic AMP mediated arrhythmias induced in the ischaemic pig heart. 1981 Jul-Aug Basic Res. Cardiol. pmid:6116488
Ishihara K et al. Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19486331
Timbermont L et al. Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. 2010 Avian Pathol. pmid:20390546
Van Deun K et al. Short-chain fatty acids and L-lactate as feed additives to control Campylobacter jejuni infections in broilers. 2008 Avian Pathol. pmid:18622853
Henriksen M et al. Evaluation of PCR and DNA sequencing for direct detection of Clostridium perfringens in the intestinal tract of broilers. 2009 Avian Dis. pmid:19848086
Van Immerseel F et al. Interactions of butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro. 2004 Apr-Jun Avian Dis. pmid:15283426