butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Periodontal Diseases D010510 15 associated lipids
Dental Leakage D003763 5 associated lipids
Lymphoproliferative Disorders D008232 7 associated lipids
Thalassemia D013789 8 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Carcinoma, Renal Cell D002292 12 associated lipids
Nervous System Diseases D009422 37 associated lipids
Phenylketonurias D010661 7 associated lipids
Per page 10 20 50 100 | Total 149

PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

Download all related citations
Per page 10 20 50 100 | Total 7933
Authors Title Published Journal PubMed Link
Corfe BM et al. A study protocol to investigate the relationship between dietary fibre intake and fermentation, colon cell turnover, global protein acetylation and early carcinogenesis: the FACT study. 2009 BMC Cancer pmid:19765278
Jiang Y et al. Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication. 2004 BMC Cancer pmid:15456519
Gao FH et al. Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. 2010 BMC Cancer pmid:21054888
Suzuki R et al. Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. 2007 BMC Cancer pmid:17506908
Shi H et al. Expression of CIAPIN1 in human colorectal cancer and its correlation with prognosis. 2010 BMC Cancer pmid:20815902
Rademakers SE et al. Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. 2011 BMC Cancer pmid:21569415
Turinetto V et al. The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status. 2009 BMC Cancer pmid:19674456
Advani AS et al. Histone H4 acetylation by immunohistochemistry and prognosis in newly diagnosed adult acute lymphoblastic leukemia (ALL) patients. 2010 BMC Cancer pmid:20663136
Lee SJ et al. Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo. 2011 BMC Cancer pmid:21501498
Liffers ST et al. Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε. 2011 BMC Cancer pmid:21492476
Juengel E et al. Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells. 2009 BMC Cancer pmid:19473483
Robe PA et al. Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells. 2005 BMC Cancer pmid:15804364
Mühlethaler-Mottet A et al. Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. 2006 BMC Cancer pmid:16930472
Tan EL et al. Quantification of Epstein-Barr virus DNA load, interleukin-6, interleukin-10, transforming growth factor-beta1 and stem cell factor in plasma of patients with nasopharyngeal carcinoma. 2006 BMC Cancer pmid:16995954
Puppin C et al. HEX expression and localization in normal mammary gland and breast carcinoma. 2006 BMC Cancer pmid:16854221
Hanafusa T et al. Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation. 2005 BMC Cancer pmid:15661074
Müller I et al. Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by methyl-CpG binding proteins and histone modifications. 2010 BMC Cancer pmid:20565761
Ross PL et al. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. 2009 BMC Cancer pmid:19245716
Ravizza R et al. Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin. 2004 BMC Cancer pmid:15601469
Muratori C et al. Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way. 2006 BMC Biotechnol. pmid:17192195
Leitner NR et al. A time- and dose-dependent STAT1 expression system. 2006 BMC Biotechnol. pmid:17184522
Mezzetti B et al. The defH9-iaaM auxin-synthesizing gene increases plant fecundity and fruit production in strawberry and raspberry. 2004 BMC Biotechnol. pmid:15113427
Pandolfini T et al. Optimisation of transgene action at the post-transcriptional level: high quality parthenocarpic fruits in industrial tomatoes. 2002 BMC Biotechnol. pmid:11818033
Jiang Z et al. Efficient display of active lipase LipB52 with a Pichia pastoris cell surface display system and comparison with the LipB52 displayed on Saccharomyces cerevisiae cell surface. 2008 BMC Biotechnol. pmid:18221563
Deurholt T et al. Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. 2009 BMC Biotechnol. pmid:19845959
Brady D et al. Spherezymes: a novel structured self-immobilisation enzyme technology. 2008 BMC Biotechnol. pmid:18237402
Meleady P et al. Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype. 2011 BMC Biotechnol. pmid:21781345
Park JS et al. Solubility enhancement of aggregation-prone heterologous proteins by fusion expression using stress-responsive Escherichia coli protein, RpoS. 2008 BMC Biotechnol. pmid:18282304
Cribbs AP et al. Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells. 2013 BMC Biotechnol. pmid:24215295
Dryhurst D et al. Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates. 2009 BMC Biol. pmid:20003410
Orrego M et al. Differential affinity of mammalian histone H1 somatic subtypes for DNA and chromatin. 2007 BMC Biol. pmid:17498293
Schmidt MC et al. Efficient α, β-motif finder for identification of phenotype-related functional modules. 2011 BMC Bioinformatics pmid:22078292
Nagaraj SH et al. In silico analysis of expressed sequence tags from Trichostrongylus vitrinus (Nematoda): comparison of the automated ESTExplorer workflow platform with conventional database searches. 2008 BMC Bioinformatics pmid:18315841
Dawany NB and Tozeren A Asymmetric microarray data produces gene lists highly predictive of research literature on multiple cancer types. 2010 BMC Bioinformatics pmid:20875095
Pang H and Zhao H Building pathway clusters from Random Forests classification using class votes. 2008 BMC Bioinformatics pmid:18254968
Jing F et al. Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. 2011 BMC Biochem. pmid:21831316
Chiou SY et al. Probing stereoselective inhibition of the acyl binding site of cholesterol esterase with four diastereomers of 2'-N-alpha-methylbenzylcarbamyl-1, 1'-bi-2-naphthol. 2005 BMC Biochem. pmid:16176589
Ngubo M et al. Nano-electrospray tandem mass spectrometric analysis of the acetylation state of histones H3 and H4 in stationary phase in Saccharomyces cerevisiae. 2011 BMC Biochem. pmid:21726436
Li L et al. Histone deacetylase inhibitor sodium butyrate suppresses DNA double strand break repair induced by etoposide more effectively in MCF-7 cells than in HEK293 cells. 2015 BMC Biochem. pmid:25592494
Jeong JH et al. Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells. 2011 BMB Rep pmid:21699753
Kim SO et al. Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells. 2009 BMB Rep pmid:19874710
Park JA et al. Differentiation and upregulation of heat shock protein 70 induced by a subset of histone deacetylase inhibitors in mouse and human embryonic stem cells. 2011 BMB Rep pmid:21429295
Rochette J et al. Fetal hemoglobin levels in adults. 1994 Blood Rev. pmid:7534152
Fathallah H et al. Epigenetic analysis of the human alpha- and beta-globin gene clusters. Blood Cells Mol. Dis. pmid:18029204
Dutta A et al. Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells. 2011 Blood Cells Mol. Dis. pmid:21094617
Chen Z et al. BCL11A represses HBG transcription in K562 cells. 2009 Mar-Apr Blood Cells Mol. Dis. pmid:19153051
Ramakrishnan V and Pace BS Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway. 2011 Blood Cells Mol. Dis. pmid:21497119
Han L et al. Sodium butyrate activates erythroid-specific 5-aminolevulinate synthase gene through Sp1 elements at its promoter. Blood Cells Mol. Dis. pmid:18555711
Ghosh SK et al. Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents. Blood Cells Mol. Dis. pmid:17161633
Domenica Cappellini M et al. Oral isobutyramide therapy in patients with thalassemia intermedia: results of a phase II open study. 2000 Blood Cells Mol. Dis. pmid:10772882
Fathallah H et al. Differences in response to fetal hemoglobin induction therapy in beta-thalassemia and sickle cell disease. Blood Cells Mol. Dis. pmid:19346141
Grebenová D et al. The proteomic study of sodium butyrate antiproliferative/cytodifferentiation effects on K562 cells. Blood Cells Mol. Dis. pmid:16978890
Ross DW et al. Leukemic cell maturation: variability of the myeloid leukemic cell phenotype. 1986 Blood Cells pmid:3466656
Guerrasio A et al. Embryonic and fetal hemoglobin synthesis in K562 cell line. 1981 Blood Cells pmid:6198015
Breitman TR and Gallo RC New facts and speculations on human myeloid leukemias. 1981 Blood Cells pmid:6964818
Vainchenker W et al. Heterogeneity in the cellular commitment of a human leukemic cell line: K 562. 1981 Blood Cells pmid:6945884
Mankidy R et al. Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex. 2006 Blood pmid:16849648
Liakopoulou E et al. Stimulation of fetal hemoglobin production by short chain fatty acids. 1995 Blood pmid:7579419
Pace BS et al. Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. 2002 Blood pmid:12393583
Maeda T et al. Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. 2000 Blood pmid:11090069
McCachren SS et al. Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation. 1986 Blood pmid:3015282
Safaya S et al. Augmentation of gamma-globin gene promoter activity by carboxylic acids and components of the human beta-globin locus control region. 1994 Blood pmid:7949149
Toye AM et al. Band 3 Courcouronnes (Ser667Phe): a trafficking mutant differentially rescued by wild-type band 3 and glycophorin A. 2008 Blood pmid:18174378
Weinberg RS et al. Butyrate increases the efficiency of translation of gamma-globin mRNA. 2005 Blood pmid:15479724
Rahman MM et al. Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. 2003 Blood pmid:12511413
Perrine SP et al. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. 1989 Blood pmid:2473801
Koyama Y et al. Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis. 2000 Blood pmid:10942396
Cohn PD et al. Differences in nonspecific esterase from normal and leukemic monocytes. 1987 Blood pmid:3580567
Zhou DC et al. Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. 2002 Blood pmid:11830487
Huber D et al. Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. 2002 Blood pmid:11986218
Durie BG et al. Myelomonocytic myeloma cell line (LB 84-1). 1989 Blood pmid:2492835
Zhao KW et al. Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. 2004 Blood pmid:15308560
Rubio MA et al. Granulocyte-macrophage colony-stimulating factor, phorbol ester, and sodium butyrate induce the CD11c integrin gene promoter activity during myeloid cell differentiation. 1995 Blood pmid:7579338
Constantoulakis P et al. On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC. 1989 Blood pmid:2478217
Scoggan KA et al. Differential activation of leukotriene biosynthesis by granulocyte-macrophage colony-stimulating factor and interleukin-5 in an eosinophilic substrain of HL-60 cells. 1995 Blood pmid:7579457
Fathallah H et al. Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin. 2007 Blood pmid:17638855
Inhorn L et al. Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase. 1988 Blood pmid:3128344
Cioè L et al. Modulation of hemoglobin synthesis in K-562(S) cells treated with interferons. 1983 Blood pmid:6301582
Blau CA et al. Fetal hemoglobin induction with butyric acid: efficacy and toxicity. 1993 Blood pmid:8422469
Tandon NN et al. Synergistic effects of butyrate on platelet responses to arachidonate, A23187, PGE1, and forskolin. 1986 Blood pmid:3080038
Fibach E et al. Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia. 1993 Blood pmid:7691251
Hock RA et al. Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines. 1989 Blood pmid:2752148
Rowley PT et al. K562 human erythroleukemia cells demonstrate commitment. 1985 Blood pmid:3919782
Witt O et al. Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. 2000 Blood pmid:10733512
Ishiguro K and Sartorelli AC Clonal variability in beta-globin mRNA content in an interleukin-3-dependent bone marrow cell line transfected with the erythropoietin receptor before and after stimulation with erythropoietin. 1997 Blood pmid:9310478
Fiskus W et al. Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. 2008 Blood pmid:18660379
Yu C et al. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. 2003 Blood pmid:12893773
Ghosh SK et al. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. 2012 Blood pmid:22160379
Witt O et al. Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. 2003 Blood pmid:12393499
Jing Y et al. Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. 2002 Blood pmid:12130515
Atkins KB and Troen BR Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate. 1995 Blood pmid:7670094
Zon LI et al. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. 1993 Blood pmid:8507862
Smith RD et al. Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. 2000 Blood pmid:10648397
Steinberg HN et al. Loss of suppression of normal bone marrow colony formation by leukemic cell lines after differentiation is induced by chemical agents. 1985 Blood pmid:3838080
Faille A et al. Differential expression of HLA-DR and HLA-DC/DS molecules in a patient with hairy cell leukemia: restoration of HLA-DC/DS expression by (12-0-tetradecanoyl phorbol-13-acetate), 5 azacytidine, and sodium butyrate. 1984 Blood pmid:6203577
Moulding DA et al. Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. 1998 Blood pmid:9746790
Vlasáková J et al. Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein. 2007 Blood pmid:17062732
Rafferty SP et al. Inhibition of hemoglobin expression by heterologous production of nitric oxide synthase in the K562 erythroleukemic cell line. 1996 Blood pmid:8704216
Chan WC et al. Large granular lymphocyte proliferation: an analysis of T-cell receptor gene arrangement and expression and the effect of in vitro culture with inducing agents. 1988 Blood pmid:2961380
Reich S et al. Oral isobutyramide reduces transfusion requirements in some patients with homozygous beta-thalassemia. 2000 Blood pmid:11071627