| MeSH term | MeSH ID | Detail |
|---|---|---|
| Periodontal Diseases | D010510 | 15 associated lipids |
| Dental Leakage | D003763 | 5 associated lipids |
| Lymphoproliferative Disorders | D008232 | 7 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Phenylketonurias | D010661 | 7 associated lipids |
butyric acid
butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with butyric acid?
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with butyric acid
PubChem Associated disorders and diseases
What pathways are associated with butyric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with butyric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with butyric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with butyric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with butyric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with butyric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with butyric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Montiel F et al. | Presence of insulin receptors in cultured glial C6 cells. Regulation by butyrate. | 1989 | Biochem. J. | pmid:2930502 |
| Hansen JK and Knudsen J | Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of butyrate and hexanoate by lactating cow mammary gland fatty acid synthetase. | 1980 | Biochem. J. | pmid:7370014 |
| Williamson DH et al. | Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats. | 1980 | Biochem. J. | pmid:7378069 |
| Higgins PJ et al. | Cell-shape-dependent modulation of p52(PAI-1) gene expression involves a secondary response pathway. | 1995 | Biochem. J. | pmid:7887903 |
| Metcalf EC et al. | The effect of ligand presaturation on the interaction of serum albumins with an immobilized Cibacron Blue 3G-A studied by affinity gel electrophoresis. | 1981 | Biochem. J. | pmid:7340816 |
| Kottel RH and Fishman WH | Placental alkaline phosphatase isoenzyme expression by the non-HeLa DoT cervical-carcinoma cell line. | 1981 | Biochem. J. | pmid:7342975 |
| Ovens MJ et al. | AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. | 2010 | Biochem. J. | pmid:19929853 |
| Higgins PJ and Ryan MP | Biochemical localization of the transformation-sensitive 52 kDa (p52) protein to the substratum contact regions of cultured rat fibroblasts. Butyrate induction, characterization, and quantification of p52 in v-ras transformed cells. | 1989 | Biochem. J. | pmid:2920008 |
| Davidson AM and Halestrap AP | Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content. | 1987 | Biochem. J. | pmid:2825649 |
| Kooistra T et al. | Butyrate stimulates tissue-type plasminogen-activator synthesis in cultured human endothelial cells. | 1987 | Biochem. J. | pmid:2827633 |
| Porteous JW | Glutamate, glutamine, aspartate, asparagine, glucose and ketone-body metabolism in chick intestinal brush-border cells. | 1980 | Biochem. J. | pmid:7470024 |
| Crabtree B et al. | Evidence that the production of acetate in rat hepatocytes is a predominantly cytoplasmic process. | 1989 | Biochem. J. | pmid:2564776 |
| Lecona E et al. | Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms. | 2008 | Biochem. J. | pmid:17760565 |
| Benito M et al. | Regulation of ketogenesis during the suckling-weanling transition in the rat. Studies with isolated hepatocytes. | 1979 | Biochem. J. | pmid:226064 |
| Hendzel MJ and Davie JR | Dynamically acetylated histones of chicken erythrocytes are selectively methylated. | 1991 | Biochem. J. | pmid:1996971 |
| Menevse A et al. | A chemical-modification approach to the olfactory code. Studies with a thiol-specific reagent. | 1978 | Biochem. J. | pmid:311638 |
| Higgins PJ and Ryan MP | p52(PAI-1) and actin expression in butyrate-induced flat revertants of v-ras-transformed rat kidney cells. | 1991 | Biochem. J. | pmid:1953684 |
| Kondo M et al. | Identification of the mRNA and polypeptide subunit for prostaglandin endoperoxide synthase from mouse mastocytoma P-815 cells. | 1983 | Biochem. J. | pmid:6135418 |
| Brass EP and Beyerinck RA | Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids. | 1988 | Biochem. J. | pmid:3134008 |
| Helliger W et al. | Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells. | 1992 | Biochem. J. | pmid:1471988 |
| Garsetti D et al. | Butyric acid-induced differentiation of HL-60 cells increases the expression of a single lysophospholipase. | 1992 | Biochem. J. | pmid:1471998 |
| Mollinedo F et al. | Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes. | 1993 | Biochem. J. | pmid:8363564 |
| Davis MG et al. | Involvement of Gialpha2 in sodium butyrate-induced erythroblastic differentiation of K562 cells. | 2000 | Biochem. J. | pmid:10677366 |
| Vessey DA and Kelley M | Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase. | 2001 | Biochem. J. | pmid:11415461 |
| Banach-Orlowska M et al. | Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. | 2009 | Biochem. J. | pmid:19686092 |
| Arts J et al. | Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation. | 1995 | Biochem. J. | pmid:7646441 |
| Srinivas SR et al. | Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). | 2005 | Biochem. J. | pmid:16104846 |
| Davidson AM and Halestrap AP | Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate. Evidence for two distinct swelling mechanisms. | 1990 | Biochem. J. | pmid:2344354 |
| Briggs S and Freedland RA | Effect of ornithine and lactate on urea synthesis in isolated hepatocytes. | 1976 | Biochem. J. | pmid:1008850 |
| Wakelam MJ and Pette D | The breakdown of phosphatidylinositol in myoblasts stimulated to fuse by the addition of Ca2+. | 1982 | Biochem. J. | pmid:7092841 |
| ANNISON EF et al. | THE METABOLISM OF ACETIC ACID, PROPIONIC ACID AND BUTYRIC ACID IN SHEEP. | 1963 | Biochem. J. | pmid:14063864 |
| Nakada MT et al. | Genetic regulation of beta 2-adrenergic receptors in 3T3-L1 fibroblasts. | 1989 | Biochem. J. | pmid:2549959 |
| Zhang D and Nelson DA | Histone acetylation in chicken erythrocytes. Estimation of the percentage of sites actively modified. | 1986 | Biochem. J. | pmid:3827874 |
| Yarlett N et al. | Butyrate formation from glucose by the rumen protozoon Dasytricha ruminantium. | 1985 | Biochem. J. | pmid:3924032 |
| Izumi H et al. | p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene. | 2003 | Biochem. J. | pmid:12720548 |
| Grogan G | Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage. | 2005 | Biochem. J. | pmid:15934927 |
| Williamson DH and Ellington EV | Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes. | 1975 | Biochem. J. | pmid:1147901 |
| Davidson AM and Halestrap AP | Inorganic pyrophosphate is located primarily in the mitochondria of the hepatocyte and increases in parallel with the decrease in light-scattering induced by gluconeogenic hormones, butyrate and ionophore A23187. | 1988 | Biochem. J. | pmid:2845949 |
| Ardawi MS and Newsholme EA | Fuel utilization in colonocytes of the rat. | 1985 | Biochem. J. | pmid:4074334 |
| Ford WC and Candy DJ | The regulation of glycolysis in perfused locust flight muscle. | 1972 | Biochem. J. | pmid:4266373 |
| Whitelaw E and Williamson DH | Effects of lactation of ketogenesis from oleate or butyrate in rat hepatocytes. | 1977 | Biochem. J. | pmid:883950 |
| Dawson AG | Preparation and some properties of a suspension of fragmented tubules from rat kidney. | 1972 | Biochem. J. | pmid:4352429 |
| Hatayama T et al. | Effects of sodium butyrate and dibutyryl cyclic AMP on thermosensitivity of HeLa cells and their production of heat shock proteins. | 1986 | Biochem. Int. | pmid:3028421 |
| Palmer TN et al. | Can isolated spans of the tricarboxylic acid cycle operate independently? L-proline, oleate and butyrate metabolism in rat hepatocytes. | 1983 | Biochem. Int. | pmid:6435625 |
| Rius C et al. | Comparative effects of butyrate and N6, 2'-O-dibutyryladenosine-3':5'-cyclic monophosphate on growth, differentiation and gene expression in U937 human monoblastoid cells. | 1991 | Biochem. Int. | pmid:1652247 |
| Ahmed N et al. | The human promyelocytic HL60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate. | 1991 | Biochem. Int. | pmid:1652248 |
| Aller P et al. | Modification of cell growth-dependent gene transcript levels by sodium butyrate in serum stimulated fibroblasts. | 1989 | Biochem. Int. | pmid:2719709 |
| Yu BS et al. | Dynamic properties of interaction between nucleic acid bases and models of amino acids. | 1989 | Biochem. Int. | pmid:2719711 |
| Schofield PS et al. | Hormonal regulation of ketogenesis in hepatocytes from fed rats before and after glycogen depletion. | 1984 | Biochem. Int. | pmid:6098276 |
| Prasad S and Thakur MK | Age-dependent effects of sodium butyrate and hydrocortisone on acetylation of high mobility group proteins of rat liver. | 1988 | Biochem. Int. | pmid:3365268 |
| Frycz BA et al. | Transcript level of AKR1C3 is down-regulated in gastric cancer. | 2016 | Biochem. Cell Biol. | pmid:27019068 |
| Vamecq J et al. | Studies on the metabolism of glycolyl-CoA. | 1990 | Biochem. Cell Biol. | pmid:1976013 |
| Sekhavat A et al. | Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. | 2007 | Biochem. Cell Biol. | pmid:18059533 |
| Ji XJ et al. | Effect of fetal hemoglobin-stimulating medicines on the interaction of DNA and protein of important erythroid regulatory elements. | 2003 | Biochem. Cell Biol. | pmid:14569302 |
| Vargas JE et al. | Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells. | 2014 | Biochem. Cell Biol. | pmid:25070040 |
| Prasad KN et al. | Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture. | 1990 | Biochem. Cell Biol. | pmid:2177340 |
| Désilets A et al. | Inhibition by deacetylase inhibitors of IL-1-dependent induction of haptoglobin involves CCAAT/Enhancer-binding protein isoforms in intestinal epithelial cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:11027530 |
| Shimizu A et al. | CyclinG contributes to G2/M arrest of cells in response to DNA damage. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9464250 |
| Gaudier E et al. | Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15541394 |
| Reppe S et al. | Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15465005 |
| Bahn RS et al. | n-Butyrate increases c-erb A oncogene expression in human colon fibroblasts. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2447891 |
| Wächtershäuser A et al. | PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833422 |
| Gudmundsson GH et al. | Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20494122 |
| Steiner E et al. | SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047174 |
| Kaneko Y et al. | Effects of teleocidin on the morphology and c-myc expression of hepatoma cells which are not inhibited by protein kinase antagonists. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3109417 |
| Kwa FA et al. | Chlorambucil-sensitive and -resistant lymphoid cells display different responses to the histone deacetylase inhibitor, sodium butyrate. | 2010 | Biochem. Biophys. Res. Commun. | pmid:21075074 |
| Heo H et al. | Suppression of caspase-11 expression by histone deacetylase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013432 |
| Cuff MA and Shirazi-Beechey SP | The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944921 |
| Tang MJ et al. | Butyrate and TGF-beta downregulate Na,K-ATPase expression in cultured proximal tubule cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575625 |
| Morrow JS et al. | Butyrate regulates glycosylation of the glycoprotein hormone alpha subunit secreted by "glucose-starved" human liver cells. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6838600 |
| Pasvanis S et al. | High sodium butyrate levels induce MDR1 activation in colorectal cells: Impact of 15-deoxy-Δ(12,14)-prostaglandin J(2) on the resistance to saquinavir. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22293191 |
| Ogawa H et al. | Butyrate modulates gene and protein expression in human intestinal endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12963019 |
| Abramova MV et al. | e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19900401 |
| Zgouras D et al. | Modulation of angiogenesis-related protein synthesis by valproic acid. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15033455 |
| McMillan L et al. | Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873561 |
| Lee CH et al. | NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913344 |
| Arányi T et al. | Sodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17524356 |
| Garbutt GJ and Abraham EC | Stimulation of minor fetal hemoglobin synthesis in cord blood reticulocytes by butyrate. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6164369 |
| Chen TH et al. | Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17331472 |
| Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
| Kaneko Y et al. | Fibroblast-like transformation and c-myc gene alteration of human hepatocytes induced by novobiocin and butyrate. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843181 |
| Leibovitch MP and Kruh J | Effect of sodium butyrate on myoblast growth and differentiation. | 1979 | Biochem. Biophys. Res. Commun. | pmid:454435 |
| Wang CH et al. | Transcriptional repression of p21((Waf1/Cip1/Sdi1)) gene by c-jun through Sp1 site. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733944 |
| Bell PA and Jones CN | Cytotoxic effects of butyrate and other 'differentiation inducers' on immature lymphoid cells. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6176240 |
| Aung CS et al. | Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17321497 |
| Zhang Y et al. | Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20599756 |
| Chang ST and Yung BY | Potentiation of sodium butyrate-induced apoptosis by vanadate in human promyelocytic leukemia cell line HL-60. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630006 |
| Carneiro VC et al. | The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19879244 |
| Abramova MV et al. | Selective repression of c-fos gene transcription in rat embryo fibroblasts transformed by oncogenes E1A and cHa-ras. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12804589 |
| Yoneda T et al. | Sodium butyrate (SB) augments the effects of 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) on neoplastic and osteoblastic phenotype in clonal rat osteosarcoma cells. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6588971 |
| Chénais B | Requirement of GATA-1 and p45 NF-E2 expression in butyric acid-induced erythroid differentiation. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9918824 |
| Rivero JA and Adunyah SE | Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8713125 |
| Rabelo FL et al. | Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670506 |
| Shirasugi M et al. | Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27914813 |
| Nilsson NE et al. | Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684041 |
| Rabelo FL et al. | Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12589807 |
| Zgouras D et al. | Butyrate impairs intestinal tumor cell-induced angiogenesis by inhibiting HIF-1alpha nuclear translocation. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12559948 |
| Souleimani A and Asselin C | Regulation of C-fos expression by sodium butyrate in the human colon carcinoma cell line Caco-2. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8503924 |
| Han L et al. | Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904069 |
| Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |