| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphatic Metastasis | D008207 | 10 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Lymphoproliferative Disorders | D008232 | 7 associated lipids |
| Marek Disease | D008380 | 4 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Myoepithelioma | D009208 | 1 associated lipids |
| Nasopharyngeal Neoplasms | D009303 | 4 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
butyric acid
butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with butyric acid?
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with butyric acid
PubChem Associated disorders and diseases
What pathways are associated with butyric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with butyric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with butyric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with butyric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with butyric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with butyric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with butyric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saerens K et al. | Release of short chain fatty acids from cream lipids by commercial lipases and esterases. | 2008 | Biotechnol. Lett. | pmid:17914608 |
| Lee KM et al. | Butyric acid production from red algae by a newly isolated Clostridium sp. S1. | 2015 | Biotechnol. Lett. | pmid:26026964 |
| Tan W et al. | Sodium butyrate-induced histone hyperacetylation up-regulating WT1 expression in porcine kidney fibroblasts. | 2015 | Biotechnol. Lett. | pmid:25700826 |
| Nair NR et al. | Preparation of poly(L-lactide) blends and biodegradation by Lentzea waywayandensis. | 2012 | Biotechnol. Lett. | pmid:22798041 |
| Kim JS et al. | High-level scu-PA production by butyrate-treated serum-free culture of recombinant CHO cell line. | Biotechnol. Prog. | pmid:15575713 | |
| Liu X et al. | Construction and characterization of ack deleted mutant of Clostridium tyrobutyricum for enhanced butyric acid and hydrogen production. | 2006 Sep-Oct | Biotechnol. Prog. | pmid:17022663 |
| Lee JS and Lee GM | Effect of sodium butyrate on autophagy and apoptosis in Chinese hamster ovary cells. | Biotechnol. Prog. | pmid:22492702 | |
| Soto-Cruz O et al. | Modeling of growth, lactate consumption, and volatile fatty acid production by Megasphaera elsdenii cultivated in minimal and complex media. | Biotechnol. Prog. | pmid:11934285 | |
| Zhang Y et al. | Effects of ptb knockout on butyric acid fermentation by Clostridium tyrobutyricum. | 2012 Jan-Feb | Biotechnol. Prog. | pmid:22038864 |
| Soares CM et al. | Covalent coupling method for lipase immobilization on controlled pore silica in the presence of nonenzymatic proteins. | 2003 May-Jun | Biotechnol. Prog. | pmid:12790642 |
| Misaghi S et al. | Resilient immortals, characterizing and utilizing Bax/Bak deficient Chinese hamster ovary (CHO) cells for high titer antibody production. | 2013 May-Jun | Biotechnol. Prog. | pmid:23596153 |
| Zhu Y and Yang ST | Adaptation of Clostridium tyrobutyricum for enhanced tolerance to butyric acid in a fibrous-bed bioreactor. | 2003 Mar-Apr | Biotechnol. Prog. | pmid:12675573 |
| Tekucheva DN et al. | Immobilized purple bacteria for light-driven H2 production from starch and potato fermentation effluents. | Biotechnol. Prog. | pmid:21751433 | |
| Oh HK et al. | Effect of N-Acetylcystein on butyrate-treated Chinese hamster ovary cells to improve the production of recombinant human interferon-beta-1a. | Biotechnol. Prog. | pmid:16080696 | |
| Chin HL et al. | Fedbatch operation using Clostridium acetobutylicum suspension culture as biocatalyst for enhancing hydrogen production. | Biotechnol. Prog. | pmid:12675576 | |
| Rossi DL et al. | A new mammalian host cell with enhanced survival enables completely serum-free development of high-level protein production cell lines. | Biotechnol. Prog. | pmid:21473000 | |
| Rodriguez J et al. | Enhanced production of monomeric interferon-beta by CHO cells through the control of culture conditions. | Biotechnol. Prog. | pmid:15903237 | |
| Hu YC et al. | Enhancement and prolongation of baculovirus-mediated expression in mammalian cells: focuses on strategic infection and feeding. | Biotechnol. Prog. | pmid:12675574 | |
| Sung YH and Lee GM | Enhanced human thrombopoietin production by sodium butyrate addition to serum-free suspension culture of bcl-2-overexpressing CHO cells. | 2005 Jan-Feb | Biotechnol. Prog. | pmid:15903240 |
| Cockett MI et al. | High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. | 1990 | Biotechnology (N.Y.) | pmid:1369995 |
| Fallon RJ et al. | Morphologic and biosynthetic modulations of HeLa cells mediated by sodium butyrate. | 1980 | Birth Defects Orig. Artic. Ser. | pmid:6783146 |
| Tertov VV et al. | [Effect of dibutyryl-cAMP on the cholesterol ester content in human atherosclerotic aorta cells]. | 1983 | Biull Eksp Biol Med | pmid:6303477 |
| Fedotov VP et al. | [The possible participation of gap junctions in the realization of the effects of stimulators of secretory processes in the hypophysis]. | 1993 | Biull Eksp Biol Med | pmid:8123822 |
| Mankidy R et al. | Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex. | 2006 | Blood | pmid:16849648 |
| Liakopoulou E et al. | Stimulation of fetal hemoglobin production by short chain fatty acids. | 1995 | Blood | pmid:7579419 |
| Pace BS et al. | Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. | 2002 | Blood | pmid:12393583 |
| Maeda T et al. | Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. | 2000 | Blood | pmid:11090069 |
| McCachren SS et al. | Dibutyryl cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation. | 1986 | Blood | pmid:3015282 |
| Safaya S et al. | Augmentation of gamma-globin gene promoter activity by carboxylic acids and components of the human beta-globin locus control region. | 1994 | Blood | pmid:7949149 |
| Toye AM et al. | Band 3 Courcouronnes (Ser667Phe): a trafficking mutant differentially rescued by wild-type band 3 and glycophorin A. | 2008 | Blood | pmid:18174378 |
| Weinberg RS et al. | Butyrate increases the efficiency of translation of gamma-globin mRNA. | 2005 | Blood | pmid:15479724 |
| Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
| Perrine SP et al. | Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. | 1989 | Blood | pmid:2473801 |
| Koyama Y et al. | Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis. | 2000 | Blood | pmid:10942396 |
| Hutt-Taylor SR et al. | Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60. | 1988 | Blood | pmid:2446679 |
| Cohn PD et al. | Differences in nonspecific esterase from normal and leukemic monocytes. | 1987 | Blood | pmid:3580567 |
| Zhou DC et al. | Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. | 2002 | Blood | pmid:11830487 |
| Huber D et al. | Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. | 2002 | Blood | pmid:11986218 |
| Durie BG et al. | Myelomonocytic myeloma cell line (LB 84-1). | 1989 | Blood | pmid:2492835 |
| Zhao KW et al. | Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. | 2004 | Blood | pmid:15308560 |
| Rubio MA et al. | Granulocyte-macrophage colony-stimulating factor, phorbol ester, and sodium butyrate induce the CD11c integrin gene promoter activity during myeloid cell differentiation. | 1995 | Blood | pmid:7579338 |
| Constantoulakis P et al. | On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC. | 1989 | Blood | pmid:2478217 |
| Scoggan KA et al. | Differential activation of leukotriene biosynthesis by granulocyte-macrophage colony-stimulating factor and interleukin-5 in an eosinophilic substrain of HL-60 cells. | 1995 | Blood | pmid:7579457 |
| Burns LJ et al. | Butyrate induces selective transcriptional activation of a hypomethylated embryonic globin gene in adult erythroid cells. | 1988 | Blood | pmid:2460154 |
| Fathallah H et al. | Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin. | 2007 | Blood | pmid:17638855 |
| Inhorn L et al. | Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase. | 1988 | Blood | pmid:3128344 |
| Hoffman R et al. | Induction of erythropoietic colonies in a human chronic myelogenous leukemia cell line. | 1979 | Blood | pmid:291442 |
| Cioè L et al. | Modulation of hemoglobin synthesis in K-562(S) cells treated with interferons. | 1983 | Blood | pmid:6301582 |
| Blau CA et al. | Fetal hemoglobin induction with butyric acid: efficacy and toxicity. | 1993 | Blood | pmid:8422469 |
| Tandon NN et al. | Synergistic effects of butyrate on platelet responses to arachidonate, A23187, PGE1, and forskolin. | 1986 | Blood | pmid:3080038 |
| Fibach E et al. | Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia. | 1993 | Blood | pmid:7691251 |
| Hock RA et al. | Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines. | 1989 | Blood | pmid:2752148 |
| Rowley PT et al. | K562 human erythroleukemia cells demonstrate commitment. | 1985 | Blood | pmid:3919782 |
| Witt O et al. | Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. | 2000 | Blood | pmid:10733512 |
| Ishiguro K and Sartorelli AC | Clonal variability in beta-globin mRNA content in an interleukin-3-dependent bone marrow cell line transfected with the erythropoietin receptor before and after stimulation with erythropoietin. | 1997 | Blood | pmid:9310478 |
| Boosalis MS et al. | Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation. | 2001 | Blood | pmid:11342457 |
| Fiskus W et al. | Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. | 2008 | Blood | pmid:18660379 |
| Yu C et al. | The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. | 2003 | Blood | pmid:12893773 |
| Ghosh SK et al. | Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. | 2012 | Blood | pmid:22160379 |
| Witt O et al. | Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. | 2003 | Blood | pmid:12393499 |
| Gao N et al. | Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress. | 2006 | Blood | pmid:16141349 |
| Jing Y et al. | Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. | 2002 | Blood | pmid:12130515 |
| Atkins KB and Troen BR | Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate. | 1995 | Blood | pmid:7670094 |
| Bhatia H et al. | Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. | 2009 | Blood | pmid:19380871 |
| Zon LI et al. | Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. | 1993 | Blood | pmid:8507862 |
| Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
| Gabbianelli M et al. | Hemoglobin switching in unicellular erythroid culture of sibling erythroid burst-forming units: kit ligand induces a dose-dependent fetal hemoglobin reactivation potentiated by sodium butyrate. | 2000 | Blood | pmid:10828043 |
| Perrine SP et al. | A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. | 2007 | Blood | pmid:17119113 |
| Steinberg HN et al. | Loss of suppression of normal bone marrow colony formation by leukemic cell lines after differentiation is induced by chemical agents. | 1985 | Blood | pmid:3838080 |
| Komatsu N et al. | Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. | 1993 | Blood | pmid:8329702 |
| Faille A et al. | Differential expression of HLA-DR and HLA-DC/DS molecules in a patient with hairy cell leukemia: restoration of HLA-DC/DS expression by (12-0-tetradecanoyl phorbol-13-acetate), 5 azacytidine, and sodium butyrate. | 1984 | Blood | pmid:6203577 |
| Moulding DA et al. | Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. | 1998 | Blood | pmid:9746790 |
| Vlasáková J et al. | Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein. | 2007 | Blood | pmid:17062732 |
| Rafferty SP et al. | Inhibition of hemoglobin expression by heterologous production of nitric oxide synthase in the K562 erythroleukemic cell line. | 1996 | Blood | pmid:8704216 |
| Chan WC et al. | Large granular lymphocyte proliferation: an analysis of T-cell receptor gene arrangement and expression and the effect of in vitro culture with inducing agents. | 1988 | Blood | pmid:2961380 |
| Sangerman J et al. | Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2. | 2006 | Blood | pmid:16896160 |
| Reich S et al. | Oral isobutyramide reduces transfusion requirements in some patients with homozygous beta-thalassemia. | 2000 | Blood | pmid:11071627 |
| Ross DW et al. | Leukemic cell maturation: variability of the myeloid leukemic cell phenotype. | 1986 | Blood Cells | pmid:3466656 |
| Guerrasio A et al. | Embryonic and fetal hemoglobin synthesis in K562 cell line. | 1981 | Blood Cells | pmid:6198015 |
| Breitman TR and Gallo RC | New facts and speculations on human myeloid leukemias. | 1981 | Blood Cells | pmid:6964818 |
| Vainchenker W et al. | Heterogeneity in the cellular commitment of a human leukemic cell line: K 562. | 1981 | Blood Cells | pmid:6945884 |
| Fathallah H et al. | Epigenetic analysis of the human alpha- and beta-globin gene clusters. | Blood Cells Mol. Dis. | pmid:18029204 | |
| Dutta A et al. | Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells. | 2011 | Blood Cells Mol. Dis. | pmid:21094617 |
| Chen Z et al. | BCL11A represses HBG transcription in K562 cells. | 2009 Mar-Apr | Blood Cells Mol. Dis. | pmid:19153051 |
| Ramakrishnan V and Pace BS | Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway. | 2011 | Blood Cells Mol. Dis. | pmid:21497119 |
| Han L et al. | Sodium butyrate activates erythroid-specific 5-aminolevulinate synthase gene through Sp1 elements at its promoter. | Blood Cells Mol. Dis. | pmid:18555711 | |
| Ghosh SK et al. | Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected lymphoma cells to nucleoside analogue antiviral agents. | Blood Cells Mol. Dis. | pmid:17161633 | |
| Domenica Cappellini M et al. | Oral isobutyramide therapy in patients with thalassemia intermedia: results of a phase II open study. | 2000 | Blood Cells Mol. Dis. | pmid:10772882 |
| Fathallah H et al. | Differences in response to fetal hemoglobin induction therapy in beta-thalassemia and sickle cell disease. | Blood Cells Mol. Dis. | pmid:19346141 | |
| Grebenová D et al. | The proteomic study of sodium butyrate antiproliferative/cytodifferentiation effects on K562 cells. | Blood Cells Mol. Dis. | pmid:16978890 | |
| Rochette J et al. | Fetal hemoglobin levels in adults. | 1994 | Blood Rev. | pmid:7534152 |
| Jeong JH et al. | Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells. | 2011 | BMB Rep | pmid:21699753 |
| Kim SO et al. | Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells. | 2009 | BMB Rep | pmid:19874710 |
| Park JA et al. | Differentiation and upregulation of heat shock protein 70 induced by a subset of histone deacetylase inhibitors in mouse and human embryonic stem cells. | 2011 | BMB Rep | pmid:21429295 |
| Jing F et al. | Phylogenetic and experimental characterization of an acyl-ACP thioesterase family reveals significant diversity in enzymatic specificity and activity. | 2011 | BMC Biochem. | pmid:21831316 |
| Chiou SY et al. | Probing stereoselective inhibition of the acyl binding site of cholesterol esterase with four diastereomers of 2'-N-alpha-methylbenzylcarbamyl-1, 1'-bi-2-naphthol. | 2005 | BMC Biochem. | pmid:16176589 |
| Ngubo M et al. | Nano-electrospray tandem mass spectrometric analysis of the acetylation state of histones H3 and H4 in stationary phase in Saccharomyces cerevisiae. | 2011 | BMC Biochem. | pmid:21726436 |
| Li L et al. | Histone deacetylase inhibitor sodium butyrate suppresses DNA double strand break repair induced by etoposide more effectively in MCF-7 cells than in HEK293 cells. | 2015 | BMC Biochem. | pmid:25592494 |
| Nagaraj SH et al. | In silico analysis of expressed sequence tags from Trichostrongylus vitrinus (Nematoda): comparison of the automated ESTExplorer workflow platform with conventional database searches. | 2008 | BMC Bioinformatics | pmid:18315841 |
| Dawany NB and Tozeren A | Asymmetric microarray data produces gene lists highly predictive of research literature on multiple cancer types. | 2010 | BMC Bioinformatics | pmid:20875095 |