butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Hepatoblastoma D018197 10 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Ovarian Neoplasms D010051 10 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Mast-Cell Sarcoma D012515 9 associated lipids
Constipation D003248 8 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Thalassemia D013789 8 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Per page 10 20 50 100 | Total 149

PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

Download all related citations
Per page 10 20 50 100 | Total 7933
Authors Title Published Journal PubMed Link
Chacin J et al. Role of oxalacetate in lipoate effect on frog gastric mucosa. 1976 Am. J. Physiol. pmid:8990
Harada E and Kato S Effect of short-chain fatty acids on the secretory response of the ovine exocrine pancreas. 1983 Am. J. Physiol. pmid:6187225
Kenyon E et al. Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium. 1997 Am. J. Physiol. pmid:9277343
Jentsch TJ et al. Electrical properties of sodium bicarbonate symport in kidney epithelial cells (BSC-1). 1986 Am. J. Physiol. pmid:3024506
Bourne GA and Baldwin DM Evidence for cAMP as a mediator of gonadotropin secretion from female pituitaries. 1987 Am. J. Physiol. pmid:2820237
Charney AN et al. Nonionic diffusion of short-chain fatty acids across rat colon. 1998 Am. J. Physiol. pmid:9530153
Natke E Cell volume regulation of rabbit cortical collecting tubule in anisotonic media. 1990 Am. J. Physiol. pmid:2360659
Hollander D and Rim E Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. 1978 Am. J. Physiol. pmid:623249
Snow TR and Caspar T Substrate dependence of myocardial response to hypoxia in the presence of theophylline. 1983 Am. J. Physiol. pmid:6881369
Hollander D et al. Transport of butyric acid in vascularly perfused anuran small intestine: importance of pH and anion transport. 1986 Am. J. Physiol. pmid:3485924
Vinolo MA et al. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22621868
Etschmann B et al. A vH+-ATPase is present in cultured sheep ruminal epithelial cells. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16825706
Arvans DL et al. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15528251
Musch MW et al. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11254495
Kiela PR et al. Regulation of the rat NHE3 gene promoter by sodium butyrate. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11557515
Jørgensen J and Mortensen PB Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11447021
Zimmerman MA et al. Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22517765
Aschenbach JR et al. Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19264953
Shie JL et al. Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11005769
Suply E et al. Butyrate enemas enhance both cholinergic and nitrergic phenotype of myenteric neurons and neuromuscular transmission in newborn rat colon. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22492692
Lal S et al. Vagal afferent responses to fatty acids of different chain length in the rat. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11557510
Ogawa H et al. Regulated production of the chemokine CCL28 in human colon epithelium. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15246961
Ramasamy S et al. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16500920
Alrefai WA et al. Molecular cloning and promoter analysis of downregulated in adenoma (DRA). 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17761837
Saksena S et al. PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19033536
Subramanya SB et al. Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17690171
Fukushima K and Fiocchi C Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15068964
Cremin JD et al. Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637251
Kumar A et al. Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26272259
Amin MR et al. Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17540780
Xu H et al. Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26159698
Parhar K et al. Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16469826
Marcil V et al. Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12121881
Schweigel M et al. Mechanisms of Mg(2+) transport in cultured ruminal epithelial cells. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:10712259
Archer SY et al. The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16160080
Borthakur A et al. Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16150873
Borthakur A et al. The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20671196
Srinivas SR et al. Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17855766
Cuche G et al. Desensitization of ileal vagal receptors by short-chain fatty acids in pigs. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11292611
Cao Y et al. Dietary fiber enhances TGF-β signaling and growth inhibition in the gut. 2011 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:21454444
Alrefai WA et al. Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:14525727
Perry MD and Sandle GI Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19407217
Gaudier E et al. Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15308471
Wu JT et al. Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11171632
Venkatraman A et al. Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637250
Grider JR and Piland BE The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16973914
Pawelka AJ and Huizinga JD Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25540235
Hadjiagapiou C et al. Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15691871
Yuan L et al. Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20299602
Sonoyama K et al. Upregulation of activin A gene by butyrate in human colon cancer cell lines. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12540370