| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
butyric acid
butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
Cross Reference
Introduction
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with butyric acid?
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with butyric acid
PubChem Associated disorders and diseases
What pathways are associated with butyric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with butyric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with butyric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with butyric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with butyric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with butyric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with butyric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Anisimová E et al. | Chemically purified serum factor can induce both Epstein-Barr virus antigen synthesis and cell differentiation. | 1987 | Arch. Virol. | pmid:3034214 |
| Li B et al. | Expression of butyrate response factor 1 in HTLV-1-transformed cells and its transactivation by tax protein. | 2003 | Arch. Virol. | pmid:14505090 |
| Adolf GR et al. | Spontaneous production of alpha- and beta-interferon in human lymphoblastoid and lymphoma cell lines. | 1982 | Arch. Virol. | pmid:6180703 |
| Anisimová E et al. | Effects of n-butyrate and phorbol ester (TPA) on induction of Epstein-Barr virus antigens and cell differentiation. | 1984 | Arch. Virol. | pmid:6089703 |
| Roubalová K et al. | Effects of activated serum factor on the induction of Epstein-Barr virus antigens and cell differentiation. | 1985 | Arch. Virol. | pmid:2990391 |
| Asai S et al. | Ultrastructural studies on cell fusion induced by Epstein-Barr virus or N-butyrate and 12-O-tetradecanoylphorbol-13-acetate. Brief report. | 1985 | Arch. Virol. | pmid:2998304 |
| Fujita R et al. | An HDAC inhibitor increases AcMNPV gene expression in mammalian cells. | 2010 | Arch. Virol. | pmid:20186445 |
| Horz HP and Conrads G | The discussion goes on: What is the role of Euryarchaeota in humans? | 2010 | Archaea | pmid:21253553 |
| Ranganna K et al. | Sodium butyrate inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7489253 |
| Grabiec AM et al. | Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? | 2008 | Arthritis Res. Ther. | pmid:18983693 |
| Kawabata T et al. | Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis. | 2010 | Arthritis Res. Ther. | pmid:20609223 |
| Mort JS | Histone deacetylases--a new target for suppression of cartilage degradation? | 2005 | Arthritis Res. Ther. | pmid:15987498 |
| de Grauw JC et al. | A targeted lipidomics approach to the study of eicosanoid release in synovial joints. | 2011 | Arthritis Res. Ther. | pmid:21794148 |
| Young DA et al. | Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. | 2005 | Arthritis Res. Ther. | pmid:15899037 |
| Fukae J et al. | Butyrate suppresses tumor necrosis factor alpha production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element. | 2005 | Arthritis Rheum. | pmid:16142751 |
| Tayebi B et al. | Modulation of microRNAs expression in hematopoietic stem cells treated with sodium butyrate in inducing fetal hemoglobin expression. | 2017 | Artif Cells Nanomed Biotechnol | pmid:26837891 |
| AteÅŸ S et al. | Enhanced ethyl butyrate production using immobilized lipase. | 2013 | Artif Cells Nanomed Biotechnol | pmid:23305408 |
| Honecker VH and Coper H | [Stability of amphetaminil. 1. In-vitro studies]. | 1975 | Arzneimittelforschung | pmid:1174051 |
| Celasco G et al. | Pharmacological profile of 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04), a new androgen antagonist with antigonadotropic activity. | 2005 | Arzneimittelforschung | pmid:16294504 |
| Nozawa S et al. | In vitro and in vivo induction of squamous cell carcinoma antigen (SCC) in a uterine cervical cancer cell line (SKG-IIIa) with peplomycin and sodium butyrate. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:1696099 |
| Patten GS et al. | Effects of convenience rice congee supplemented diets on guinea pig whole animal and gut growth, caecal digesta SCFA and in vitro ileal contractility. | 2004 | Asia Pac J Clin Nutr | pmid:15003921 |
| Okoye TC et al. | Evaluation of the acute and sub acute toxicity of Annona senegalensis root bark extracts. | 2012 | Asian Pac J Trop Med | pmid:22449518 |
| Priyashree S et al. | Bronchodilatory and mast cell stabilising activity of Cressa cretica L.: evaluation through in vivo and in vitro experimental models. | 2012 | Asian Pac J Trop Med | pmid:22305781 |
| Ettebong EO et al. | In vivo antiplasmodial activities of ethanolic extract and fractions of Eleucine indica. | 2012 | Asian Pac J Trop Med | pmid:22805716 |
| Chinasa EC et al. | Evaluation of anti-inflammatory property of the leaves of Sansevieria liberica ger. and labr. (fam: Dracaenaceae). | 2011 | Asian Pac J Trop Med | pmid:22014734 |
| Nabandith V et al. | Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat. | Asian Pac. J. Cancer Prev. | pmid:15546251 | |
| Gandhi GK et al. | Hyperglycaemia and diabetes impair gap junctional communication among astrocytes. | 2010 | ASN Neuro | pmid:20396375 |
| Furukawa M et al. | Epstein-Barr virus early antigen induction in nasopharyngeal hybrid cells by Chinese medicinal herbs. | 1986 | Auris Nasus Larynx | pmid:3028348 |
| Furukawa M and Umeda R | Inhibitory effect of retinoid (E5166) on cell growth and suppressive effect on Epstein-Barr virus early-antigen induction by n-butyrate in nasopharyngeal hybrid cells. | 1987 | Auris Nasus Larynx | pmid:2820366 |
| Arcus AC et al. | Studies with the autotransplanted ovine pancreas: glucagon and insulin secretion. | 1976 | Aust. J. Biol. Sci. | pmid:791227 |
| Packer EL et al. | Rumen fermentation and liveweight gain in beef cattle treated with monensin and grazing lush forage. | 2011 | Aust. Vet. J. | pmid:21864305 |
| Pedersen G et al. | Cultures of human colonic epithelial cells isolated from endoscopical biopsies from patients with inflammatory bowel disease. Effect of IFNgamma, TNFalpha and IL-1beta on viability, butyrate oxidation and IL-8 secretion. | 2000 | Autoimmunity | pmid:11191284 |
| Ping W et al. | Baculovirus-mediated gene expression in chicken primary cells. | 2006 | Avian Dis. | pmid:16617983 |
| Henriksen M et al. | Evaluation of PCR and DNA sequencing for direct detection of Clostridium perfringens in the intestinal tract of broilers. | 2009 | Avian Dis. | pmid:19848086 |
| Van Immerseel F et al. | Interactions of butyric acid- and acetic acid-treated Salmonella with chicken primary cecal epithelial cells in vitro. | 2004 Apr-Jun | Avian Dis. | pmid:15283426 |
| Timbermont L et al. | Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils. | 2010 | Avian Pathol. | pmid:20390546 |
| Van Deun K et al. | Short-chain fatty acids and L-lactate as feed additives to control Campylobacter jejuni infections in broilers. | 2008 | Avian Pathol. | pmid:18622853 |
| Ishihara K et al. | Identification of urinary biomarkers useful for distinguishing a difference in mechanism of toxicity in rat model of cholestasis. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19486331 |
| Podzuweit T et al. | Cyclic AMP mediated arrhythmias induced in the ischaemic pig heart. | 1981 Jul-Aug | Basic Res. Cardiol. | pmid:6116488 |
| Moretti M et al. | Behavioral and neurochemical effects of sodium butyrate in an animal model of mania. | 2011 | Behav Pharmacol | pmid:21989497 |
| Resende WR et al. | Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer. | 2013 | Behav Pharmacol | pmid:23994816 |
| Petry FS et al. | Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction. | 2016 | Behav. Brain Res. | pmid:27025446 |
| Horii Y et al. | Exposure to TMT odor affects adrenal sympathetic nerve activity and behavioral consequences in rats. | 2010 | Behav. Brain Res. | pmid:20595033 |
| Sharma S et al. | Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: Modulation of histone deacetylase activity. | 2015 | Behav. Brain Res. | pmid:26048426 |
| Yang J et al. | Inhibition of nuclear factor-κB impairs reconsolidation of morphine reward memory in rats. | 2011 | Behav. Brain Res. | pmid:20816896 |
| Ayers LW et al. | Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal deafferentation. | 2013 | Behav. Brain Res. | pmid:23831303 |
| Kalda A et al. | Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice. | 2007 | Behav. Brain Res. | pmid:17477979 |
| Reolon GK et al. | Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. | 2011 | Behav. Brain Res. | pmid:21421011 |
| Zhu H et al. | Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: involvement of 5-HT(1A) receptors. | 2009 | Behav. Brain Res. | pmid:18817816 |
| Watanabe T et al. | Green odor and depressive-like state in rats: toward an evidence-based alternative medicine? | 2011 | Behav. Brain Res. | pmid:21684308 |
| Wallace KJ and Rosen JB | Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces. | 2000 | Behav. Neurosci. | pmid:11085605 |
| Lattal KM et al. | Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. | 2007 | Behav. Neurosci. | pmid:17907845 |
| Zhu Y et al. | [In vitro study about the inhibitory effect of CDAII in combination with sodium butyrate on breast cancer cells]. | 2007 | Beijing Da Xue Xue Bao | pmid:17940563 |
| Havenaar R | Intestinal health functions of colonic microbial metabolites: a review. | 2011 | Benef Microbes | pmid:21840809 |
| Roelofsen H et al. | The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes. | 2010 | Benef Microbes | pmid:21831781 |
| Bird AR et al. | Resistant starch, large bowel fermentation and a broader perspective of prebiotics and probiotics. | 2010 | Benef Microbes | pmid:21831780 |
| Binsl TW et al. | Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro. | 2010 | Benef Microbes | pmid:21831778 |
| Mäkeläinen H et al. | Xylo-oligosaccharides enhance the growth of bifidobacteria and Bifidobacterium lactis in a simulated colon model. | 2010 | Benef Microbes | pmid:21831753 |
| Mäkivuokko H et al. | Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model. | 2010 | Benef Microbes | pmid:21840801 |
| Fernando WM et al. | Diets supplemented with chickpea or its main oligosaccharide component raffinose modify faecal microbial composition in healthy adults. | 2010 | Benef Microbes | pmid:21831757 |
| Fürll M et al. | [Hormonal reactions in fattening bulls and cows during a three-week butyric acid exposure]. | 1993 | Berl. Munch. Tierarztl. Wochenschr. | pmid:8267563 |
| Fürll M et al. | [Effect of a three-week butyric acid exposure on the mineral metabolism and the skeletal system in cattle]. | 1993 | Berl. Munch. Tierarztl. Wochenschr. | pmid:8267564 |
| Ichikawa N et al. | Production, purification and characterization of the plasminogen activator in teratocarcinoma stem cells induced with sodium butyrate. | 1984 | Biken J | pmid:6443174 |
| Nikolić N et al. | Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells. | 2012 | Biochem Res Int | pmid:21904680 |
| Iwalokun BA et al. | Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus: An African Mistletoe. | 2011 | Biochem Res Int | pmid:21918720 |
| Rivero JA and Adunyah SE | Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9703983 |
| Gaudier E et al. | Butyrate regulation of glycosylation-related gene expression: evidence for galectin-1 upregulation in human intestinal epithelial goblet cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15541394 |
| Tong X et al. | Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15063780 |
| Bai L and Merchant JL | ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560543 |
| Seki J et al. | Dimethyl sulfoxide and related polar compounds enhance infection of human T cells with HIV-1 in vitro. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8886001 |
| BektaÅŸoÄŸlu B et al. | Novel hydroxyl radical scavenging antioxidant activity assay for water-soluble antioxidants using a modified CUPRAC method. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16716257 |
| Reppe S et al. | Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15465005 |
| Fishman PH et al. | Induction of glycolipid biosynthesis by sodium butyrate in HeLa cells. | 1974 | Biochem. Biophys. Res. Commun. | pmid:4858378 |
| Kinoshita M et al. | Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054544 |
| Tabuchi Y et al. | Identification of genes responsive to sodium butyrate in colonic epithelial cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054516 |
| Steiner E et al. | SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047174 |
| Weingarten D and de Vellis J | Selective inhibition by sodium butyrate of the glucocorticoid induction of glycerol phosphate dehydrogenase in glial cultures. | 1980 | Biochem. Biophys. Res. Commun. | pmid:6772178 |
| Mori Y et al. | Differential effect of sodium butyrate on cyclic AMP phosphodiesterase activities in butyrate sensitive and resistant mastocytoma cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3019329 |
| Ogawa H et al. | Butyrate modulates gene and protein expression in human intestinal endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12963019 |
| Abramova MV et al. | e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19900401 |
| McMillan L et al. | Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873561 |
| Lee IH et al. | Involvement of CCAAT/enhancer-binding protein alpha in haptoglobin gene expression by all-trans-retinoic acid. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12074569 |
| Gaschott T et al. | Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11676498 |
| Radhakrishnan P et al. | Butyrate induces sLex synthesis by stimulation of selective glycosyltransferase genes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17553459 |
| Staecker JL et al. | Stimulation of DNA synthesis in primary cultures of adult rat hepatocytes by sodium butyrate. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3632683 |
| Garbutt GJ and Abraham EC | Stimulation of minor fetal hemoglobin synthesis in cord blood reticulocytes by butyrate. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6164369 |
| Wei P et al. | Reversible immortalization of Nestin-positive precursor cells from pancreas and differentiation into insulin-secreting cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22266322 |
| Wächtershäuser A et al. | Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679282 |
| Hatayama H et al. | The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17374366 |
| Adolf GR and Swetly P | Effects of butyrate on induction and action of interferon. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6174120 |
| Hammill D et al. | The D-domain of Sp3 modulates its protein levels and activation of the p21(CIP1/WAF1) promoter. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16081043 |
| Gaschott T et al. | 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11322770 |
| Aung CS et al. | Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17321497 |
| Laubach VE et al. | High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579595 |
| Mandal M et al. | Redistribution of activated caspase-3 to the nucleus during butyric acid-induced apoptosis. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403841 |
| Nilsson NE et al. | Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12684041 |
| Terakawa M et al. | Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15919053 |
| Souleimani A and Asselin C | Regulation of C-fos expression by sodium butyrate in the human colon carcinoma cell line Caco-2. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8503924 |
| Han L et al. | Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904069 |
| Coats SR et al. | Ligand-specific control of src-suppressed C kinase substrate gene expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12372401 |